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    Cep72 centrosomal protein 72 [ Mus musculus (house mouse) ]

    Gene ID: 74470, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cep72provided by MGI
    Official Full Name
    centrosomal protein 72provided by MGI
    Primary source
    MGI:MGI:1921720
    See related
    Ensembl:ENSMUSG00000021572 AllianceGenome:MGI:1921720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610029E11Rik; 4933440J22Rik
    Summary
    Predicted to be involved in gamma-tubulin complex localization; microtubule cytoskeleton organization; and regulation of protein localization to centrosome. Located in centriolar satellite. Orthologous to human CEP72 (centrosomal protein 72). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 18.9), CNS E11.5 (RPKM 3.5) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cep72 in Genome Data Viewer
    Location:
    13 C1; 13 40.15 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74184351..74210439, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74036495..74062319, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15912 Neighboring gene tubulin polymerization promoting protein Neighboring gene integrin linked kinase pseudogene Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 3 Neighboring gene predicted gene, 41003 Neighboring gene exocyst complex component 3 Neighboring gene STARR-positive B cell enhancer ABC_E8534

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centriole replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-tubulin complex localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-tubulin complex localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization to centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centrosomal protein of 72 kDa
    Names
    centrosomal protein 72 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028959.3NP_083235.3  centrosomal protein of 72 kDa

      See identical proteins and their annotated locations for NP_083235.3

      Status: VALIDATED

      Source sequence(s)
      AK034892, CJ079657
      Consensus CDS
      CCDS26639.1
      UniProtKB/Swiss-Prot
      E9QQ95, Q3TU12, Q497H8, Q69ZH7, Q8BM53, Q9D0B7, Q9D3R3
      Related
      ENSMUSP00000037788.7, ENSMUST00000036456.8
      Conserved Domains (4) summary
      smart00446
      Location:117134
      LRRcap; occurring C-terminal to leucine-rich repeats
      sd00031
      Location:5576
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:5393
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:2885
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      74184351..74210439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517423.5XP_006517486.1  centrosomal protein of 72 kDa isoform X4

      UniProtKB/TrEMBL
      A0A1Y7VJU1
      Related
      ENSMUSP00000152641.2, ENSMUST00000222609.2
      Conserved Domains (3) summary
      TIGR04211
      Location:395541
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:5576
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:51150
      LRR_9; Leucine-rich repeat
    2. XM_006517422.5XP_006517485.1  centrosomal protein of 72 kDa isoform X3

      Conserved Domains (3) summary
      TIGR04211
      Location:416562
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:5576
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:51150
      LRR_9; Leucine-rich repeat
    3. XM_011244576.4XP_011242878.1  centrosomal protein of 72 kDa isoform X1

      Conserved Domains (3) summary
      TIGR04211
      Location:475621
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:5576
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:51150
      LRR_9; Leucine-rich repeat
    4. XM_030247437.2XP_030103297.1  centrosomal protein of 72 kDa isoform X2

      Conserved Domains (4) summary
      TIGR04211
      Location:426572
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:627
      LRR_1; leucine-rich repeat [structural motif]
      sd00035
      Location:5580
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam14580
      Location:2101
      LRR_9; Leucine-rich repeat
    5. XM_030247438.2XP_030103298.1  centrosomal protein of 72 kDa isoform X7

      Conserved Domains (3) summary
      TIGR04211
      Location:395541
      SH3_and_anchor; SH3 domain protein
      sd00031
      Location:5576
      LRR_1; leucine-rich repeat [structural motif]
      pfam14580
      Location:51150
      LRR_9; Leucine-rich repeat
    6. XM_006517424.5XP_006517487.1  centrosomal protein of 72 kDa isoform X5

      UniProtKB/TrEMBL
      A0A1Y7VJU1
      Conserved Domains (3) summary
      sd00031
      Location:5576
      LRR_1; leucine-rich repeat [structural motif]
      pfam10498
      Location:446557
      IFT57; Intra-flagellar transport protein 57
      pfam14580
      Location:51150
      LRR_9; Leucine-rich repeat
    7. XM_006517425.5XP_006517488.1  centrosomal protein of 72 kDa isoform X6

      UniProtKB/TrEMBL
      A0A1Y7VJU1
      Conserved Domains (3) summary
      sd00031
      Location:5576
      LRR_1; leucine-rich repeat [structural motif]
      pfam10498
      Location:446555
      IFT57; Intra-flagellar transport protein 57
      pfam14580
      Location:51150
      LRR_9; Leucine-rich repeat