figl-1 AAA domain-containing protein;Fidgetin-like protein 1;Spastin/Vps4 C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: figl-1
Official Full Name: AAA domain-containing protein;Fidgetin-like protein 1;Spastin/Vps4 C-terminal domain-containing protein
Primary source: WormBase:WBGene00017981
Locus tag: CELE_F32D1.1
See related: AllianceGenome:WB:WBGene00017981
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ATP hydrolysis activity; magnesium ion binding activity; and microtubule binding activity. Involved in ATP metabolic process and positive regulation of mitotic cell cycle. Located in nucleus. Is expressed in germ line. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to several human genes including FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See figl-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (4341431..4345999, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that the AAA domain of the FIGL-1 protein (CeFIGL-1-AAA), in clear contrast to homologous AAA domains, has an unusually high ATPase activity and forms a hexamer in solution.
Title: Structural insights into the unusually strong ATPase activity of the AAA domain of the Caenorhabditis elegans fidgetin-like 1 (FIGL-1) protein.
Data found that FIGL-1 is a nuclear protein with a monopartite nuclear localization signal and that it specifically interacts with SMO-1 in vitro and in vivo.
Title: Caenorhabditis elegans fidgetin homolog FIGL-1, a nuclear-localized AAA ATPase, binds to SUMO.
degradation of FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis.
Title: The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line.
results suggest that the unique position of cysteine 368, located immediately downstream of the Walker A motif, plays an important role in the ATP hydrolysis process of C. elegans F32D1.1 protein
Title: Identification of a cysteine residue important for the ATPase activity of C. elegans fidgetin homologue.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F32D1.2 (e-PCR)
- UniSTS:320532

F32D1.1 (e-PCR)
- UniSTS:306803

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule severing ATPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AAA domain-containing protein;Fidgetin-like protein 1;Spastin/Vps4 C-terminal domain-containing protein

NP_001317805.1

Confirmed by transcript evidence

NP_001317806.1

Confirmed by transcript evidence

NP_504197.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4341431..4345999 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071796.6 → NP_504197.1 Fidgetin-like protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504197.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O16299

Conserved Domains (4) summary

smart00382
Location:348 → 484

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:352 → 480

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:545 → 585

Vps4_C; Vps4 C terminal oligomerization domain

cl21455
Location:315 → 371

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001330855.3 → NP_001317805.1 AAA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A168H4I0
NM_001330856.3 → NP_001317806.1 Spastin/Vps4 C-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A168H4M8

Conserved Domains (1) summary

pfam09336
Location:2 → 30

Vps4_C; Vps4 C terminal oligomerization domain