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    skr-20 Skp1-related protein [ Caenorhabditis elegans ]

    Gene ID: 181445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    skr-20
    Official Full Name
    Skp1-related protein
    Primary source
    WormBase:WBGene00004826
    Locus tag
    CELE_R12H7.5
    See related
    AllianceGenome:WB:WBGene00004826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See skr-20 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_003284.9 (13223016..13223537, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Innexin;Innexin unc-9 Neighboring gene G_PROTEIN_RECEP_F2_4 domain-containing protein Neighboring gene Aspartic protease 4 Neighboring gene Skp1-related protein Neighboring gene SKP1 component POZ domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age. Fielenbach N, et al. Dev Cell, 2007 Mar. PMID 17336909
    2. Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Ghazi A, et al. Proc Natl Acad Sci U S A, 2007 Apr 3. PMID 17392428, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Skp1-related protein
    NP_510192.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13223016..13223537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077791.6 → NP_510192.1  Skp1-related protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE98
      Conserved Domains (2) summary
      smart00512
      Location:7 → 116
      Skp1; Found in Skp1 protein family
      pfam01466
      Location:90 → 154
      Skp1; Skp1 family, dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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