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    CFLAR CASP8 and FADD like apoptosis regulator [ Bos taurus (domestic cattle) ]

    Gene ID: 497199, updated on 1-Jan-2025

    Summary

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    Official Symbol
    CFLARprovided by VGNC
    Official Full Name
    CASP8 and FADD like apoptosis regulatorprovided by VGNC
    Primary source
    VGNC:VGNC:27255
    See related
    BGD:BT15630; Ensembl:ENSBTAG00000010998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    FLIP
    Orthologs
    human mouse all
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    Genomic context

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    See CFLAR in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (89704174..89762443)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene caspase-10 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene caspase 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Expression and localization of cFLIP, an anti-apoptotic factor, in the bovine corpus luteum. Hojo T, et al. J Reprod Dev, 2010 Apr. PMID 20035105
    2. Sequencing, chromosomal mapping, and functional characterization of bovine FLICE-like inhibitory protein (FLIP). Szperka ME, et al. Cytogenet Genome Res, 2006. PMID 16276095
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicate downregulation of cFLIP during structural luteal regression, suggesting that cFLIP plays a survival role in the bovine corpus luteum
      Title: Expression and localization of cFLIP, an anti-apoptotic factor, in the bovine corpus luteum.
    2. Conservation of FLIP's ability to inhibit apoptosis and to downregulate NF-kappaB activation across species.
      Title: Sequencing, chromosomal mapping, and functional characterization of bovine FLICE-like inhibitory protein (FLIP).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CASP8 and FADD-like apoptosis regulator
    Names
    FLICE-like inhibitory protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012281.2 → NP_001012281.2  CASP8 and FADD-like apoptosis regulator

      Status: VALIDATED

      Source sequence(s)
      NKLS02000002
      UniProtKB/TrEMBL
      A0A3Q1MFY0, F1N346, Q5FX62
      Related
      ENSBTAP00000073134.1, ENSBTAT00000085853.2

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      89704174..89762443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005202603.5 → XP_005202660.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_005202660.1

      UniProtKB/TrEMBL
      A0A3Q1MFY0, F1N346, Q5FX62
      Conserved Domains (3) summary
      cd08337
      Location:28 → 107
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:118 → 198
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:273 → 510
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    2. XM_024999538.2 → XP_024855306.1  CASP8 and FADD-like apoptosis regulator isoform X2

      UniProtKB/TrEMBL
      A0A3Q1MLX3, A0A3Q1N3I3
      Related
      ENSBTAP00000064085.1, ENSBTAT00000076795.2
      Conserved Domains (3) summary
      cd08337
      Location:28 → 107
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:118 → 198
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:247 → 466
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    3. XM_010802165.4 → XP_010800467.1  CASP8 and FADD-like apoptosis regulator isoform X3

      UniProtKB/TrEMBL
      F1N346, Q5FX62
      Conserved Domains (2) summary
      cd08340
      Location:1 → 75
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:150 → 387
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    4. XM_024999533.2 → XP_024855301.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MFY0, F1N346, Q5FX62
      Conserved Domains (3) summary
      cd08337
      Location:28 → 107
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:118 → 198
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:273 → 510
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    5. XM_005202605.5 → XP_005202662.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_005202662.1

      UniProtKB/TrEMBL
      A0A3Q1MFY0, F1N346, Q5FX62
      Conserved Domains (3) summary
      cd08337
      Location:28 → 107
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:118 → 198
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:273 → 510
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    6. XM_005202604.5 → XP_005202661.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_005202661.1

      UniProtKB/TrEMBL
      A0A3Q1MFY0, F1N346, Q5FX62
      Conserved Domains (3) summary
      cd08337
      Location:28 → 107
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:118 → 198
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:273 → 510
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    7. XM_059892075.1 → XP_059748058.1  CASP8 and FADD-like apoptosis regulator isoform X4

    8. XM_024999561.2 → XP_024855329.1  CASP8 and FADD-like apoptosis regulator isoform X4

      Conserved Domains (1) summary
      cl00042
      Location:57 → 294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    Nucleotide Protein Strain
    Heading Accession and Version

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