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    Cgn cingulin [ Mus musculus (house mouse) ]

    Gene ID: 70737, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cgnprovided by MGI
    Official Full Name
    cingulinprovided by MGI
    Primary source
    MGI:MGI:1927237
    See related
    Ensembl:ENSMUSG00000068876 AllianceGenome:MGI:1927237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330408J11Rik
    Summary
    Enables microtubule binding activity. Acts upstream of or within bicellular tight junction assembly; epithelial cell morphogenesis; and microtubule cytoskeleton organization. Located in bicellular tight junction and brush border. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; pituitary gland; and respiratory system. Orthologous to human CGN (cingulin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 14.9), colon adult (RPKM 11.8) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Cgn in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94667376..94695036, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94760069..94787725, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene selenium binding protein 2 Neighboring gene tuftelin 1 pseudogene Neighboring gene predicted gene, 52626 Neighboring gene STARR-positive B cell enhancer ABC_E3448 Neighboring gene STARR-seq mESC enhancer starr_08357 Neighboring gene predicted gene, 40094 Neighboring gene pogo transposable element with ZNF domain Neighboring gene special AT-rich sequence binding protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118157

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037711.3NP_001032800.3  cingulin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
      Source sequence(s)
      AC087903
      Consensus CDS
      CCDS50984.2
      UniProtKB/Swiss-Prot
      P59242, Q05BC4, Q69ZM0, Q6P2K0
      UniProtKB/TrEMBL
      E9QMC1
      Related
      ENSMUSP00000102894.3, ENSMUST00000107273.9
      Conserved Domains (1) summary
      pfam01576
      Location:3561140
      Myosin_tail_1; Myosin tail
    2. NM_001293727.2NP_001280656.2  cingulin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC087903
      Consensus CDS
      CCDS79976.2
      UniProtKB/Swiss-Prot
      P59242, Q05BC4, Q69ZM0, Q6P2K0
      UniProtKB/TrEMBL
      D3YUW7
      Related
      ENSMUSP00000102893.3, ENSMUST00000107272.7
      Conserved Domains (1) summary
      pfam01576
      Location:3481132
      Myosin_tail_1; Myosin tail

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      94667376..94695036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252817.1XP_030108677.1  cingulin isoform X2

      UniProtKB/Swiss-Prot
      P59242, Q05BC4, Q69ZM0, Q6P2K0
      Conserved Domains (1) summary
      pfam01576
      Location:3491133
      Myosin_tail_1; Myosin tail
    2. XM_006502061.2XP_006502124.1  cingulin isoform X1

      UniProtKB/Swiss-Prot
      P59242, Q05BC4, Q69ZM0, Q6P2K0
      UniProtKB/TrEMBL
      A0A5F8MPT6
      Conserved Domains (1) summary
      pfam01576
      Location:3571141
      Myosin_tail_1; Myosin tail
    3. XM_006502062.5XP_006502125.1  cingulin isoform X1

      UniProtKB/Swiss-Prot
      P59242, Q05BC4, Q69ZM0, Q6P2K0
      UniProtKB/TrEMBL
      A0A5F8MPT6
      Conserved Domains (1) summary
      pfam01576
      Location:3571141
      Myosin_tail_1; Myosin tail
    4. XM_006502064.1XP_006502127.1  cingulin isoform X3

      UniProtKB/TrEMBL
      Q32NZ7
      Conserved Domains (1) summary
      COG1196
      Location:345645
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_375578.1 RNA Sequence