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    Chrdl2 chordin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 69121, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Chrdl2provided by MGI
    Official Full Name
    chordin-like 2provided by MGI
    Primary source
    MGI:MGI:1916371
    See related
    Ensembl:ENSMUSG00000030732 AllianceGenome:MGI:1916371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chl2; 1810022C01Rik
    Summary
    Predicted to enable BMP binding activity. Acts upstream of or within chondrocyte differentiation and negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Is expressed in colon; genitourinary system; liver; and musculoskeletal system. Orthologous to human CHRDL2 (chordin like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 4.3), placenta adult (RPKM 2.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chrdl2 in Genome Data Viewer
    Location:
    7 E2; 7 54.29 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (99655611..99683935)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100006404..100034728)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 169 Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19665 Neighboring gene SET translocation pseudogene Neighboring gene polymerase (DNA-directed), delta 3, accessory subunit Neighboring gene STARR-positive B cell enhancer ABC_E3737 Neighboring gene predicted gene, 34760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Oren A, et al. Gene, 2004 Apr 28. PMID 15094188
    2. Development of the vertebral morphogenetic field in the mouse: interactions between Crossveinless-2 and Twisted Gastrulation. Zakin L, et al. Dev Biol, 2008 Nov 1. PMID 18789316, Free PMC Article
    3. Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells. Souilhol C, et al. Nat Commun, 2016 Mar 8. PMID 26952187, Free PMC Article
    4. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. Nakayama N, et al. Development, 2004 Jan. PMID 14660436
    5. BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Forsman CL, et al. Dev Biol, 2013 Jan 1. PMID 23103586, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CHL2 expression is restricted to chondrocytes of various developing joint cartilage surfaces and connective tissues in reproductive organs.
      Title: A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chordin-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291320.1 → NP_001278249.1  chordin-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001278249.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC161205, AF338222, AK007577
      Consensus CDS
      CCDS80755.1
      UniProtKB/Swiss-Prot
      Q8VEA6, Q925I3
      UniProtKB/TrEMBL
      D3YV59
      Related
      ENSMUSP00000102699.2, ENSMUST00000107084.8
      Conserved Domains (1) summary
      cl17735
      Location:255 → 317
      VWC; von Willebrand factor type C domain

    2. NM_133709.3 → NP_598470.3  chordin-like protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_598470.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate first exon in place of that of variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC113298, AC161205, AF338222
      Consensus CDS
      CCDS21492.1
      UniProtKB/Swiss-Prot
      Q8VEA6, Q925I3
      UniProtKB/TrEMBL
      A0A0B4J1E8
      Related
      ENSMUSP00000032977.5, ENSMUST00000032977.11
      Conserved Domains (2) summary
      pfam00093
      Location:248 → 310
      VWC; von Willebrand factor type C domain
      cl17735
      Location:33 → 95
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      99655611..99683935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508177.4 → XP_006508240.1  chordin-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VEA6, Q925I3
      Conserved Domains (1) summary
      pfam00093
      Location:163 → 225
      VWC; von Willebrand factor type C domain

    2. XM_006508178.1 → XP_006508241.1  chordin-like protein 2 isoform X2

      Conserved Domains (1) summary
      pfam00093
      Location:96 → 158
      VWC; von Willebrand factor type C domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEA6.1 GenPept UniProtKB/Swiss-Prot:Q8VEA6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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