SLC16A1 solute carrier family 16 member 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: SLC16A1provided by VGNC
Official Full Name: solute carrier family 16 member 1provided by VGNC
Primary source: VGNC:VGNC:34683
See related: BGD:BT19465; Ensembl:ENSBTAG00000015107
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: MCT1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (30380839..30414648)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The goal of this study was to elucidate the distribution of MCT1 along the gastrointestinal tract of calves and adult cows.
Title: Subacute ruminal acidosis suppressed the expression of MCT1 in rumen of cows.
both granulosa and theca cells of ERK1/2-inhibited follicles had higher expression of SLC16A1, a monocarboxylate transporter, transporting substances including beta-hydroxybutyrate across the plasma membrane. Taken together, ERK1/2 plays a significant role in mediating LH surge-induced gene expression in granulosa and theca cells of the ovulating follicle in cattle.
Title: ERK1/2-dependent gene expression in the bovine ovulating follicle.
This study confirmed age-dependent changes of MCT1 expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
Title: Differences in monocarboxylic acid transporter type 1 expression in rumen epithelium of newborn calves due to age and milk or milk replacer feeding.
These findings show that MCT 1 increases with the development of rumen function and also in adult animals MCT 1 may change with the feeding.
Title: Effects of age and concentrate feeding on the expression of MCT 1 and CD147 in the gastrointestinal tract of goats and Hereford finishing beef bulls.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
Title: Monocarboxylate transporter 1 (MCT1) mediates transport of short-chain fatty acids in bovine caecum.
This study investigated the distribution and expression of monocarboxylate transporter 1 (MCT1) in the livers of pre-ruminant calves and adult bovines (bulls and cows), using different molecular biological techniques.
Title: Monocarboxylate transporter 1 (MCT1) in the liver of pre-ruminant and adult bovines.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
Title: Expression and distribution of monocarboxylate transporter 1 (MCT1) in the gastrointestinal tract of calves.

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General gene information

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Markers

Slc16a1 (e-PCR), detects polymorphism
- UniSTS:461930

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables monocarboxylic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in monocarboxylic acid transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: monocarboxylate transporter 1

Names: MCT 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037319.1 → NP_001032396.1 monocarboxylate transporter 1

See identical proteins and their annotated locations for NP_001032396.1

Status: PROVISIONAL

Source sequence(s)

BC104598

UniProtKB/Swiss-Prot

Q3MHW6

UniProtKB/TrEMBL

Q2HWF1

Related

ENSBTAP00000020102.2, ENSBTAT00000020102.3

Conserved Domains (1) summary

TIGR00892
Location:1 → 473

2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

Range

30380839..30414648

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024986151.2 → XP_024841919.1 monocarboxylate transporter 1 isoform X1

UniProtKB/Swiss-Prot

Q3MHW6

UniProtKB/TrEMBL

Q2HWF1

Conserved Domains (1) summary

TIGR00892
Location:1 → 473

2A0113; monocarboxylate transporter 1
XM_059882554.1 → XP_059738537.1 monocarboxylate transporter 1 isoform X1

UniProtKB/Swiss-Prot

Q3MHW6

UniProtKB/TrEMBL

Q2HWF1
XM_059882555.1 → XP_059738538.1 monocarboxylate transporter 1 isoform X1

UniProtKB/Swiss-Prot

Q3MHW6

UniProtKB/TrEMBL

Q2HWF1