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    TLR6 toll like receptor 6 [ Bos taurus (domestic cattle) ]

    Gene ID: 407237, updated on 1-Jan-2025

    Summary

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    Official Symbol
    TLR6provided by VGNC
    Official Full Name
    toll like receptor 6provided by VGNC
    Primary source
    VGNC:VGNC:50030
    See related
    Ensembl:ENSBTAG00000014031
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    TLR1
    Orthologs
    human mouse all
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    Genomic context

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    See TLR6 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (58050661..58091640, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene KLF transcription factor 3 Neighboring gene uncharacterized LOC112447069 Neighboring gene uncharacterized LOC112447068 Neighboring gene toll like receptor 10 Neighboring gene family with sequence similarity 114 member A1 Neighboring gene uncharacterized LOC132345565 Neighboring gene transmembrane protein 156

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Toll-like receptor 6 gene polymorphisms increase the risk of bovine tuberculosis in Chinese Holstein cattle. Song Y, et al. Acta Histochem, 2014 Sep. PMID 25017737
    2. Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6. Turner ML, et al. Endocrinology, 2014 Apr. PMID 24437488, Free PMC Article
    3. Identification of full length bovine TLR1 and functional characterization of lipopeptide recognition by bovine TLR2/1 heterodimer. Farhat K, et al. Vet Res, 2010 May-Jun. PMID 20167196, Free PMC Article
    4. Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6. Seabury CM, et al. Genomics, 2008 Oct. PMID 18639626
    5. Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10. Opsal MA, et al. Gene, 2006 Dec 15. PMID 16950576

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variants in the TLR6 gene are associated with susceptibility to bovine TB.
      Title: Toll-like receptor 6 gene polymorphisms increase the risk of bovine tuberculosis in Chinese Holstein cattle.
    2. TLR2, TLR1, and TLR6 haev roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides by epithelial and stromal cells of bovine endometrium
      Title: Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1, and TLR6.
    3. Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6.
      Title: Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6.
    4. The expression analysis showed similar expression profiles for TLR1 and TLR6, which indicate a co-regulation of these two genes, TLR10 had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 and TLR6.
      Title: Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Toll-like receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipopeptide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to diacyl bacterial lipopeptide IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Toll-like receptor 2-Toll-like receptor 6 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 6
    Names
    Toll-like receptor 1
    Toll-like receptor 1 long form
    NP_001001159.1
    XP_010804360.1
    XP_010804361.1
    XP_010804363.1
    XP_024848845.1
    XP_024848846.1
    XP_059743380.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001159.1 → NP_001001159.1  toll-like receptor 6 precursor

      See identical proteins and their annotated locations for NP_001001159.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ618974
      UniProtKB/Swiss-Prot
      B5T272, B5T275, B5T276, Q3BK20, Q704V6, Q706D2
      Conserved Domains (6) summary
      smart00082
      Location:529 → 582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641 → 784
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:43 → 164
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:356 → 378
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 134
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      58050661..58091640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010806061.4 → XP_010804363.1  toll-like receptor 6 isoform X1

      See identical proteins and their annotated locations for XP_010804363.1

      UniProtKB/Swiss-Prot
      B5T272, B5T275, B5T276, Q3BK20, Q704V6, Q706D2
      UniProtKB/TrEMBL
      F1MV95
      Related
      ENSBTAP00000087537.1, ENSBTAT00000135647.1
      Conserved Domains (6) summary
      smart00082
      Location:529 → 582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641 → 784
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:356 → 378
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 134
      LRR_8; Leucine rich repeat
      cl26793
      Location:46 → 494
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    2. XM_024993077.2 → XP_024848845.1  toll-like receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      B5T272, B5T275, B5T276, Q3BK20, Q704V6, Q706D2
      UniProtKB/TrEMBL
      F1MV95
      Related
      ENSBTAP00000092481.1, ENSBTAT00000092898.1
      Conserved Domains (6) summary
      smart00082
      Location:529 → 582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641 → 784
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:356 → 378
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 134
      LRR_8; Leucine rich repeat
      cl26793
      Location:46 → 494
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    3. XM_059887397.1 → XP_059743380.1  toll-like receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      B5T272, B5T275, B5T276, Q3BK20, Q704V6, Q706D2
      UniProtKB/TrEMBL
      F1MV95
      Related
      ENSBTAP00000101313.1, ENSBTAT00000109942.1

    4. XM_010806059.4 → XP_010804361.1  toll-like receptor 6 isoform X1

      See identical proteins and their annotated locations for XP_010804361.1

      UniProtKB/Swiss-Prot
      B5T272, B5T275, B5T276, Q3BK20, Q704V6, Q706D2
      UniProtKB/TrEMBL
      F1MV95
      Conserved Domains (6) summary
      smart00082
      Location:529 → 582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641 → 784
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:356 → 378
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 134
      LRR_8; Leucine rich repeat
      cl26793
      Location:46 → 494
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    5. XM_024993078.2 → XP_024848846.1  toll-like receptor 6 isoform X1

      UniProtKB/Swiss-Prot
      B5T272, B5T275, B5T276, Q3BK20, Q704V6, Q706D2
      UniProtKB/TrEMBL
      F1MV95
      Related
      ENSBTAP00000035880.6, ENSBTAT00000036014.6
      Conserved Domains (6) summary
      smart00082
      Location:529 → 582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641 → 784
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:356 → 378
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 134
      LRR_8; Leucine rich repeat
      cl26793
      Location:46 → 494
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    6. XM_010806058.4 → XP_010804360.1  toll-like receptor 6 isoform X1

      See identical proteins and their annotated locations for XP_010804360.1

      UniProtKB/Swiss-Prot
      B5T272, B5T275, B5T276, Q3BK20, Q704V6, Q706D2
      UniProtKB/TrEMBL
      F1MV95
      Conserved Domains (6) summary
      smart00082
      Location:529 → 582
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:641 → 784
      TIR; Toll - interleukin 1 - resistance
      sd00031
      Location:54 → 77
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:356 → 378
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 134
      LRR_8; Leucine rich repeat
      cl26793
      Location:46 → 494
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    RNA

    1. XR_009494754.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q704V6.1 GenPept UniProtKB/Swiss-Prot:Q704V6

    Gene LinkOut

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