CREBBP CREB binding protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: CREBBPprovided by HGNC
Official Full Name: CREB binding proteinprovided by HGNC
Primary source: HGNC:HGNC:2348
See related: Ensembl:ENSG00000005339 MIM:600140; AllianceGenome:HGNC:2348
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CBP; RSTS; KAT3A; MKHK1; RSTS1
Summary: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Expression: Ubiquitous expression in testis (RPKM 12.8), bone marrow (RPKM 12.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (3725054..3880713, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (3752324..3907918, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (3775055..3930714, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.
Title: CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.
AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.
Title: AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.
CBP-mediated FOXO4 acetylation facilitates postmenopausal osteoporosis (PMO) progression through the inhibition of the Wnt/beta-catenin signaling pathway.
Title: CBP-mediated FOXO4 acetylation facilitates postmenopausal osteoporosis (PMO) progression through the inhibition of the Wnt/β-catenin signaling pathway.
BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion.
Title: BCOR::CREBBP fusion in malignant neuroepithelial tumor of CNS expands the spectrum of methylation class CNS tumor with BCOR/BCOR(L1)-fusion.
NOTCH1 and CREBBP co-mutations negatively affect the benefit of adjuvant therapy in completely resected EGFR-mutated NSCLC: translational research of phase III IMPACT study.
Title: NOTCH1 and CREBBP co-mutations negatively affect the benefit of adjuvant therapy in completely resected EGFR-mutated NSCLC: translational research of phase III IMPACT study.
Molecular insight into CREBBP and TANGO2 variants causing intellectual disability.
Title: Molecular insight into CREBBP and TANGO2 variants causing intellectual disability.
CBP and RAD21 Proteins Bind at the Termini of Forum Domains in Human Chromosomes.
Title: CBP and RAD21 Proteins Bind at the Termini of Forum Domains in Human Chromosomes.
The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.
Title: The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.
beta-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer.
Title: β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer.
The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.
Title: The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.

Submit: New GeneRIF Correction See all GeneRIFs (323)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Menke-Hennekam syndrome 1 MedGen: C5193034 OMIM: 618332 GeneReviews: Not available	not available
Rubinstein-Taybi syndrome due to CREBBP mutations MedGen: C4551859 OMIM: 180849 GeneReviews: Rubinstein-Taybi Syndrome	not available

Copy number response

Description
Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2019-10-23) ClinGen Genome Curation PagePubMed Triplosensitivity No evidence available (Last evaluated 2019-10-23) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Binding of HIV-1 Tat to p300 induces a conformational change in the CBP/p300 complex such that it can acquire and bind better to basal transcription factors, indicating Tat helps CBP/p300 recruit new partners to the transcription machinery	PubMed
	tat	HIV-1 Tat recruits the CBP/p300 complex, as well as other known cellular acetyltransferases, to the HIV-1 LTR promoter, an effect involved in the acetylation of histones H3 and H4, and HIV-1 transcriptional activation	PubMed
	tat	HIV-1 Tat binding peaks in Tat expression Jurkat cells are associated with specific cellular factors (CBP and ETS) and chromatin marks (H3K4me3 and H3K27me3) in Jurkat cells	PubMed
	tat	HIV-1 Tat treatment of hematopoietic progenitor cells upregulates CBP gene expression (7- to 9-fold) and protein levels (5- to 7-fold) within 6-12 hours after stimulation	PubMed
	tat	The N-terminal 24 amino acids of HIV-1 Tat mediate its binding to the KIX domain (amino acids 589-679) of CBP	PubMed
	tat	HIV-1 Tat regulates the activity of CBP by inhibiting CBP acetylation of histones, but not CBP acetylation of p53 or MyoD, indicating Tat induces a substrate selectivity for CBP	PubMed
	tat	HIV-1 Tat inhibits the histone acetyltransferase and transcriptional activation activities of CBP, an effect mediated by amino acids 86-101 of Tat	PubMed
	tat	HIV-1 Tat induces CBP to complex with NFkappaB p65 and bind to the IL-8 promoter leading to an upregulation of IL-8 expression	PubMed
	tat	Acetylation of the p50 subunit of NFkappaB by CBP/p300 is regulated by HIV-1 Tat	PubMed
	tat	HIV-1 Tat binds to the minimal histone acetyltransferase domain of the CBP/p300 complex (amino acids 1253-1710 of p300) and E1a binding domain (amino acids 1542-1710) of p300, an effect mediated by the basic domain (amino acids 48-57) of Tat	PubMed
	tat	Acetylation of HIV-1 Tat by the p300/CBP complex at Lys50 regulates Tat binding to cyclin T1 and HIV-1 TAR RNA, as well as Tat-mediated transactivation of the HIV-1 LTR promoter, by allowing Tat to dissociate from TAR RNA	PubMed
	tat	HIV-1 Tat is acetylated by the p300/CBP complex on Lys50 and Lys51	PubMed
	tat	HIV-1 Tat induces the polyubiquitination and degradation of Tip60 through p300/CBP-associated E4-type ubiquitin-ligase activity, which results in a dramatic impairment of the Tip60-dependent apoptotic cell response to DNA damage	PubMed
Vpr	vpr	HIV-1 Vpr binds directly to the CBP co-activator to induce transcription of the HIV-1 LTR and glucocorticoid-responsive promoters	PubMed
integrase	gag-pol	Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that CREBBP gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with CREBBP	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH65203 (e-PCR)
- UniSTS:86021

Crebbp (e-PCR), detects polymorphism
- UniSTS:516615

A009N45 (e-PCR)
- UniSTS:30221

PMC337043P1 (e-PCR)
- UniSTS:273169

G32692 (e-PCR)
- UniSTS:117274

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-60562 (e-PCR)
- UniSTS:32355

RH68748 (e-PCR)
- UniSTS:64112

D16S2906 (e-PCR)
- UniSTS:153477

CREBBP_555 (e-PCR)
- UniSTS:277127

RH65024 (e-PCR)
- UniSTS:84383

D16S2622-D16S3027 (e-PCR)
- UniSTS:229543

D16S2622-D16S3027 (e-PCR)
- UniSTS:229544

D16S2622-D16S3027 (e-PCR)
- UniSTS:229545

RH78556 (e-PCR)
- UniSTS:22962

G64268 (e-PCR)
- UniSTS:158644

WI-22537 (e-PCR)
- UniSTS:24526

D16S3385 (e-PCR)
- UniSTS:474326

RH66116 (e-PCR)
- UniSTS:70366

D16S3065 (e-PCR), detects polymorphism
- UniSTS:61426

CREBBP (e-PCR)
- UniSTS:504819

MARC_13559-13560:1000751712:1 (e-PCR)
- UniSTS:267509

b10501s (e-PCR)
- UniSTS:17142

STS-U89355 (e-PCR)
- UniSTS:53494

RH66115 (e-PCR)
- UniSTS:19450

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables MRF binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	TAS Traceable Author Statement more info	PubMed
enables acetyltransferase activity	EXP Inferred from Experiment more info	PubMed
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables histone lactyltransferase (CoA-dependent) activity	IEA Inferred from Electronic Annotation more info
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide N-acetyltransferase activity	TAS Traceable Author Statement more info
enables peptide lactyltransferase (CoA-dependent) activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	EXP Inferred from Experiment more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-lysine acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in embryonic digit morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in homeostatic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein acetylation	TAS Traceable Author Statement more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cellular response to heat	TAS Traceable Author Statement more info
involved_in regulation of smoothened signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in response to hypoxia	TAS Traceable Author Statement more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in stimulatory C-type lectin receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CREB-binding protein

Names: histone lysine acetyltransferase CREBBP; protein lactyltransferas CREBBP; protein-lysine acetyltransferase CREBBP

NP_001073315.1

EC 2.3.1.48

NP_004371.2

EC 2.3.1.48

XP_005255181.1

EC 2.3.1.48

XP_005255182.1

EC 2.3.1.48

XP_006720911.1

EC 2.3.1.48

XP_011520683.1

EC 2.3.1.48

XP_011520684.1

EC 2.3.1.48

XP_016878433.1

EC 2.3.1.48

XP_047289580.1

EC 2.3.1.48

XP_047289581.1

EC 2.3.1.48

XP_054235594.1

EC 2.3.1.48

XP_054235595.1

EC 2.3.1.48

XP_054235596.1

EC 2.3.1.48

XP_054235597.1

EC 2.3.1.48

XP_054235598.1

EC 2.3.1.48

XP_054235599.1

EC 2.3.1.48

XP_054235600.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009873.2 RefSeqGene

Range

5001..160660

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1426

mRNA and Protein(s)

NM_001079846.1 → NP_001073315.1 CREB-binding protein isoform b

See identical proteins and their annotated locations for NP_001073315.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AB210043, AC006111, U85962

Consensus CDS

CCDS45399.1

UniProtKB/Swiss-Prot

Q92793

Related

ENSP00000371502.3, ENST00000382070.7

Conserved Domains (10) summary

cd05495
Location:1049 → 1156

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1728 → 1806

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1667 → 1707

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1948 → 2375

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1168 → 1240

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1242 → 1273

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02135
Location:363 → 405

zf-TAZ; TAZ zinc finger

pfam02172
Location:549 → 629

KIX; KIX domain

pfam08214
Location:1304 → 1611

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1996 → 2073

Creb_binding; Creb binding
NM_004380.3 → NP_004371.2 CREB-binding protein isoform a

See identical proteins and their annotated locations for NP_004371.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).

Source sequence(s)

AB210043, AC006111, U85962

Consensus CDS

CCDS10509.1

UniProtKB/Swiss-Prot

D3DUC9, O00147, Q16376, Q4LE28, Q92793

Related

ENSP00000262367.5, ENST00000262367.10

Conserved Domains (10) summary

cd05495
Location:1087 → 1194

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1766 → 1844

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1705 → 1745

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1986 → 2413

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1206 → 1278

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1280 → 1311

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02135
Location:363 → 430

zf-TAZ; TAZ zinc finger

pfam02172
Location:587 → 667

KIX; KIX domain

pfam08214
Location:1342 → 1649

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2034 → 2111

Creb_binding; Creb binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

3725054..3880713 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047433625.1 → XP_047289581.1 CREB-binding protein isoform X4
XM_047433624.1 → XP_047289580.1 CREB-binding protein isoform X3
XM_005255124.5 → XP_005255181.1 CREB-binding protein isoform X2

Conserved Domains (10) summary

cd05495
Location:1072 → 1179

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1751 → 1829

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1690 → 1730

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1971 → 2398

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1191 → 1263

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1265 → 1296

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02135
Location:363 → 430

zf-TAZ; TAZ zinc finger

pfam02172
Location:587 → 667

KIX; KIX domain

pfam08214
Location:1327 → 1634

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2019 → 2096

Creb_binding; Creb binding
XM_005255125.5 → XP_005255182.1 CREB-binding protein isoform X6

Conserved Domains (10) summary

cd05495
Location:948 → 1055

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1627 → 1705

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1566 → 1606

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1821 → 2274

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1067 → 1139

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1141 → 1172

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02135
Location:363 → 430

zf-TAZ; TAZ zinc finger

pfam02172
Location:587 → 667

KIX; KIX domain

pfam08214
Location:1203 → 1510

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1895 → 1972

Creb_binding; Creb binding
XM_017022944.2 → XP_016878433.1 CREB-binding protein isoform X1
XM_006720848.4 → XP_006720911.1 CREB-binding protein isoform X5

Conserved Domains (10) summary

cd05495
Location:1087 → 1194

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1679 → 1757

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1618 → 1658

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1899 → 2326

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1206 → 1278

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1280 → 1311

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02135
Location:363 → 430

zf-TAZ; TAZ zinc finger

pfam02172
Location:587 → 667

KIX; KIX domain

pfam09030
Location:1947 → 2024

Creb_binding; Creb binding

cl02120
Location:1342 → 1562

HAT_KAT11; Histone acetylation protein
XM_011522381.3 → XP_011520683.1 CREB-binding protein isoform X7

Conserved Domains (10) summary

cd05495
Location:836 → 943

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1515 → 1593

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1454 → 1494

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1735 → 2162

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:955 → 1027

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1029 → 1060

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02135
Location:112 → 179

zf-TAZ; TAZ zinc finger

pfam02172
Location:336 → 416

KIX; KIX domain

pfam08214
Location:1091 → 1398

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1783 → 1860

Creb_binding; Creb binding
XM_011522382.4 → XP_011520684.1 CREB-binding protein isoform X8

Conserved Domains (4) summary

cd05495
Location:1087 → 1194

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

cd15802
Location:1206 → 1278

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

pfam02135
Location:363 → 430

zf-TAZ; TAZ zinc finger

pfam02172
Location:587 → 667

KIX; KIX domain