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    Wsb1 WD repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 78889, updated on 10-Dec-2024

    Summary

    Official Symbol
    Wsb1provided by MGI
    Official Full Name
    WD repeat and SOCS box-containing 1provided by MGI
    Primary source
    MGI:MGI:1926139
    See related
    Ensembl:ENSMUSG00000017677 AllianceGenome:MGI:1926139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110056B13Rik; 2700038M07Rik
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein K27-linked ubiquitination. Acts upstream of or within protein aggregate center assembly. Located in cytoplasm. Is expressed in nervous system and neural retina. Orthologous to human WSB1 (WD repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 127.9), CNS E14 (RPKM 125.2) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Wsb1 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79130208..79145521, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79239382..79254709, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5251 Neighboring gene predicted gene 11201 Neighboring gene kinase suppressor of ras 1 Neighboring gene STARR-seq mESC enhancer starr_30109 Neighboring gene STARR-positive B cell enhancer ABC_E5252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:78955902-78956103 Neighboring gene STARR-positive B cell enhancer ABC_E10696 Neighboring gene STARR-positive B cell enhancer ABC_E5253 Neighboring gene predicted gene, 30413 Neighboring gene STARR-seq mESC enhancer starr_30112 Neighboring gene predicted gene, 30470 Neighboring gene STARR-seq mESC enhancer starr_30114 Neighboring gene STARR-positive B cell enhancer ABC_E10697 Neighboring gene predicted gene, 30561 Neighboring gene STARR-seq mESC enhancer starr_30117 Neighboring gene neurofibromin 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm PubMed 

    General protein information

    Preferred Names
    WD repeat and SOCS box-containing protein 1
    Names
    WD-40-repeat-containing protein with a SOCS box 1
    WSB-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042565.3NP_001036030.1  WD repeat and SOCS box-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001036030.1

      Status: VALIDATED

      Source sequence(s)
      AI644176, AK048511, BG069536
      UniProtKB/TrEMBL
      Q8C841, Q8VE81
      Related
      ENSMUST00000150416.8
      Conserved Domains (3) summary
      sd00039
      Location:1757
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:140178
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl29593
      Location:1146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_019653.3NP_062627.3  WD repeat and SOCS box-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_062627.3

      Status: VALIDATED

      Source sequence(s)
      AK167394, BB431254, BY097910
      Consensus CDS
      CCDS25118.1
      UniProtKB/Swiss-Prot
      O54927
      UniProtKB/TrEMBL
      Q3TFQ2, Q3TIA1, Q3U7R9, Q7TMU2
      Related
      ENSMUSP00000017821.6, ENSMUST00000017821.12
      Conserved Domains (4) summary
      COG2319
      Location:139382
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:135388
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:174212
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:382420
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      79130208..79145521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157103.1XP_036012996.1  WD repeat and SOCS box-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      Q8C841, Q8VE81
      Conserved Domains (3) summary
      sd00039
      Location:1757
      7WD40; WD40 repeat [structural motif]
      cl02533
      Location:140178
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
      cl29593
      Location:1146
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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