U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    SPICE1 spindle and centriole associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 152185, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPICE1provided by HGNC
    Official Full Name
    spindle and centriole associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:25083
    See related
    Ensembl:ENSG00000163611 MIM:613447; AllianceGenome:HGNC:25083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPICE; CCDC52
    Summary
    Involved in metaphase chromosome alignment; mitotic spindle assembly; and regulation of centriole replication. Located in centriole; centrosome; and spindle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 3.6), endometrium (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPICE1 in Genome Data Viewer
    Location:
    3q13.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (113442718..113515156, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (116163861..116236319, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113161565..113234003, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SPICE1-CFAP44 readthrough (NMD candidate) Neighboring gene cilia and flagella associated protein 44 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:113085321-113085822 Neighboring gene RABGGTB pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3247 Neighboring gene PHF5A pseudogene 2 Neighboring gene CFAP44 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20251 Neighboring gene microRNA 8076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:113176937-113177646 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:113177647-113178356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20260 Neighboring gene SID1 transmembrane family member 1 Neighboring gene SIDT1 antisense RNA 1 Neighboring gene microRNA 4446

    Genomic regions, transcripts, and products

    Bibliography

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (50 hits/1272 screens)

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Interactions

    General gene information

    Potential readthrough

    Included gene: CFAP44

    Readthrough SPICE1-CFAP44

    Readthrough gene: SPICE1-CFAP44, Included gene: CFAP44

    Clone Names

    • FLJ26064, FLJ44949

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cell division  
    involved_in metaphase chromosome alignment  
    involved_in metaphase chromosome alignment PubMed 
    involved_in mitotic spindle assembly  
    involved_in mitotic spindle assembly PubMed 
    involved_in regulation of centriole replication  
    involved_in regulation of centriole replication PubMed 
    Component Evidence Code Pubs
    is_active_in centriole  
    located_in centriole PubMed 
    is_active_in centrosome  
    located_in centrosome PubMed 
    located_in cytoplasm  
    is_active_in spindle  
    located_in spindle PubMed 

    General protein information

    Preferred Names
    spindle and centriole-associated protein 1
    Names
    coiled-coil domain-containing protein 52

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331078.2NP_001318007.1  spindle and centriole-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      AC112128
      Consensus CDS
      CCDS2973.1
      UniProtKB/Swiss-Prot
      D3DN72, Q8N0Z3, Q8WUX6
      Conserved Domains (1) summary
      pfam15678
      Location:36434
      SPICE; Centriole duplication and mitotic chromosome congression
    2. NM_001331079.2NP_001318008.2  spindle and centriole-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      AC112128
      Consensus CDS
      CCDS2973.1
      UniProtKB/Swiss-Prot
      D3DN72, Q8N0Z3, Q8WUX6
      Conserved Domains (1) summary
      pfam15678
      Location:36434
      SPICE; Centriole duplication and mitotic chromosome congression
    3. NM_001387939.1NP_001374868.1  spindle and centriole-associated protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC112128
      Consensus CDS
      CCDS2973.1
      UniProtKB/Swiss-Prot
      D3DN72, Q8N0Z3, Q8WUX6
      Conserved Domains (1) summary
      pfam15678
      Location:36434
      SPICE; Centriole duplication and mitotic chromosome congression
    4. NM_144718.4NP_653319.1  spindle and centriole-associated protein 1

      See identical proteins and their annotated locations for NP_653319.1

      Status: VALIDATED

      Source sequence(s)
      AC112128, AY099107, BP278430, U79249
      Consensus CDS
      CCDS2973.1
      UniProtKB/Swiss-Prot
      D3DN72, Q8N0Z3, Q8WUX6
      Related
      ENSP00000295872.4, ENST00000295872.8
      Conserved Domains (1) summary
      pfam15678
      Location:36434
      SPICE; Centriole duplication and mitotic chromosome congression

    RNA

    1. NR_170870.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112128

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      113442718..113515156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      116163861..116236319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.