Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Rev
|
rev
|
Depletion of endogenous HIV-1 Rev binding protein (hRIP) by RNA interference results in the loss of viral replication in human cell lines and primary macrophages; virus production is restored to wild-type levels after reintroduction of hRIP protein |
PubMed
|
|
rev
|
hRIP/Rab is known to interact with CRM1 (exportin 1) as part of its cofactor involvement with Rev-mediated nuclear export of HIV-1 mRNA |
PubMed
|
|
rev
|
hRIP/Rab is a nucleoporin like protein that binds to the activation domain of HIV-1 Rev (amino acids 75-83) and acts as a cofactor for Rev-mediated nuclear export of HIV-1 mRNA |
PubMed
|
|
rev
|
hRIP is an essential cellular HIV-1 Rev cofactor; abolishing hRIP activity with a dominant-negative mutant or RNA interference causes Rev-directed mRNAs to mislocalize and aberrantly accumulate at the nuclear periphery |
PubMed
|
Go to the HIV-1, Human Interaction Database