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    ASF1 nucleosome assembly factor ASF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853327, updated on 9-Dec-2024

    Summary

    Official Symbol
    ASF1
    Official Full Name
    nucleosome assembly factor ASF1
    Primary source
    SGD:S000003651
    Locus tag
    YJL115W
    See related
    AllianceGenome:SGD:S000003651; FungiDB:YJL115W; VEuPathDB:YJL115W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CIA1
    Summary
    Enables histone binding activity. Involved in several processes, including DNA replication-dependent chromatin assembly; chromatin remodeling; and positive regulation of transcription elongation by RNA polymerase II. Located in cytosol and nucleus. Orthologous to several human genes including ASF1A (anti-silencing function 1A histone chaperone). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ASF1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (196287..197126)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Pho86p Neighboring gene SUN family protein NCA3 Neighboring gene tRNA-Ala Neighboring gene gag protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone binding  
    enables histone binding  
    enables histone binding PubMed 
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromosome, telomeric region  
    located_in cytosol PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    nucleosome assembly factor ASF1
    NP_012420.1
    • Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      196287..197126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181548.1 → NP_012420.1  TPA: nucleosome assembly factor ASF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW69, P32447
      UniProtKB/TrEMBL
      B3LQ02, B5VL60, C7GQ11, C8ZB51, G2WGQ6, N1P246
      Conserved Domains (1) summary
      pfam04729
      Location:1 → 154
      ASF1_hist_chap; ASF1 like histone chaperone
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