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    NOP1 rRNA methyltransferase NOP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851548, updated on 9-Dec-2024

    Summary

    Official Symbol
    NOP1
    Official Full Name
    rRNA methyltransferase NOP1
    Primary source
    SGD:S000002172
    Locus tag
    YDL014W
    See related
    AllianceGenome:SGD:S000002172; FungiDB:YDL014W; VEuPathDB:YDL014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LOT3
    Summary
    Enables histone H2AQ104 methyltransferase activity and rRNA methyltransferase activity. Involved in box C/D sno(s)RNA 3'-end processing and rRNA methylation. Located in nucleolus. Part of box C/D methylation guide snoRNP complex and small-subunit processome. Orthologous to human FBL (fibrillarin) and FBLL1 (fibrillarin like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See NOP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (427364..428347)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase CDC7 Neighboring gene trans-2-enoyl-CoA reductase (NADPH) TSC13 Neighboring gene SUMO-targeted ubiquitin ligase complex subunit SLX5 Neighboring gene uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding  
    enables histone H2AQ104 methyltransferase activity  
    enables histone H2AQ104 methyltransferase activity PubMed 
    enables methyltransferase activity  
    enables rRNA methyltransferase activity  
    enables rRNA methyltransferase activity PubMed 
    enables rRNA methyltransferase activity PubMed 
    Process Evidence Code Pubs
    involved_in box C/D sno(s)RNA 3'-end processing  
    involved_in box C/D sno(s)RNA 3'-end processing PubMed 
    involved_in chromatin remodeling  
    involved_in methylation  
    involved_in rRNA methylation  
    involved_in rRNA methylation PubMed 
    involved_in rRNA methylation PubMed 
    involved_in rRNA processing  
    involved_in rRNA processing PubMed 
    involved_in ribosome biogenesis  
    Component Evidence Code Pubs
    part_of 90S preribosome PubMed 
    part_of box C/D methylation guide snoRNP complex  
    part_of box C/D methylation guide snoRNP complex PubMed 
    is_active_in nucleolus  
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleus  
    part_of ribonucleoprotein complex  
    part_of small-subunit processome  
    part_of small-subunit processome PubMed 

    General protein information

    Preferred Names
    rRNA methyltransferase NOP1
    NP_010270.1
    • Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; inviability of the null mutant is functionally complemented by human FBL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      427364..428347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180073.1 → NP_010270.1  TPA: rRNA methyltransferase NOP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRX5, P15646, P89890
      UniProtKB/TrEMBL
      A6ZXV4, B3LGS1, C7GW64, C8Z4Q5, G2WCE1, N1P5Y0
      Conserved Domains (1) summary
      PTZ00146
      Location:85 → 320
      PTZ00146; fibrillarin; Provisional
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