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    Dcaf13 DDB1 and CUL4 associated factor 13 [ Mus musculus (house mouse) ]

    Gene ID: 223499, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dcaf13provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 13provided by MGI
    Primary source
    MGI:MGI:2684929
    See related
    Ensembl:ENSMUSG00000022300 AllianceGenome:MGI:2684929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm83; Wdsof1
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in decidualization; oocyte growth; and rRNA processing. Located in nucleolus. Part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in several structures, including blastocyst; early embryo; and primary oocyte. Orthologous to human DCAF13 (DDB1 and CUL4 associated factor 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 20.4), CNS E11.5 (RPKM 18.9) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dcaf13 in Genome Data Viewer
    Location:
    15 B3.1; 15 15.42 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (38976300..39010251)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (39112874..39146856)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38472 Neighboring gene STARR-positive B cell enhancer mm9_chr15:38944202-38944502 Neighboring gene solute carrier family 25, member 32 Neighboring gene collagen triple helix repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_38473 Neighboring gene STARR-seq mESC enhancer starr_38474 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_38478 Neighboring gene regulating synaptic membrane exocytosis 2 Neighboring gene STARR-seq mESC enhancer starr_38479 Neighboring gene STARR-seq mESC enhancer starr_38480 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC65348

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 13
    Names
    WD repeat and SOF domain-containing protein 1
    WD repeats and SOF domain containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416064.1NP_001402993.1  DDB1- and CUL4-associated factor 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101886, AC164883
    2. NM_198606.3NP_941008.2  DDB1- and CUL4-associated factor 13 isoform 1

      See identical proteins and their annotated locations for NP_941008.2

      Status: VALIDATED

      Source sequence(s)
      AC101886, AC164883
      Consensus CDS
      CCDS37066.1
      UniProtKB/Swiss-Prot
      E9QPL0, Q6PAC3
      Related
      ENSMUSP00000022909.9, ENSMUST00000022909.10
      Conserved Domains (4) summary
      COG2319
      Location:1360
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:59353
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04158
      Location:354438
      Sof1; Sof1-like domain
      sd00039
      Location:70107
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      38976300..39010251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)