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    PFA4 palmitoyltransferase PFA4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854159, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PFA4
    Official Full Name
    palmitoyltransferase PFA4
    Primary source
    SGD:S000005363
    Locus tag
    YOL003C
    See related
    AllianceGenome:SGD:S000005363; FungiDB:YOL003C; VEuPathDB:YOL003C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables palmitoyltransferase activity. Involved in protein palmitoylation. Located in endoplasmic reticulum. Orthologous to human ZDHHC21 (zinc finger DHHC-type palmitoyltransferase 21); ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23); and ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PFA4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (321858..322994, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II core subunit RPB11 Neighboring gene transcriptional regulator SIN3 Neighboring gene PAQR-type receptor Neighboring gene Pho80p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane. Fontana GA, et al. Nat Commun, 2019 Jun 10. PMID 31182712, Free PMC Article
    2. Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3. Lam KK, et al. J Cell Biol, 2006 Jul 3. PMID 16818716, Free PMC Article
    3. Specificity of transmembrane protein palmitoylation in yeast. González Montoro A, et al. PLoS One, 2011 Feb 24. PMID 21383992, Free PMC Article
    4. The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p. Smotrys JE, et al. J Cell Biol, 2005 Sep 26. PMID 16186255, Free PMC Article
    5. Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1. Park S, et al. Proc Natl Acad Sci U S A, 2011 Aug 30. PMID 21844336, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4.
      Title: The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4.
    2. We find that Chs3 is palmitoylated and that this modification is Pfa4-dependent, indicating that Pfa4 is indeed a protein acyl transferase.
      Title: Palmitoylation by the DHHC protein Pfa4 regulates the ER exit of Chs3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase PFA4
    NP_014640.1
    • Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      321858..322994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183257.1 → NP_014640.1  TPA: palmitoyltransferase PFA4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014640.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W264, Q12006
      UniProtKB/TrEMBL
      A6ZNK3, B3LJ53, C7GJV5
      Conserved Domains (1) summary
      COG5273
      Location:1 → 344
      COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12006.1

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