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    KAT6B lysine acetyltransferase 6B [ Homo sapiens (human) ]

    Gene ID: 23522, updated on 27-Nov-2024

    Summary

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    Official Symbol
    KAT6Bprovided by HGNC
    Official Full Name
    lysine acetyltransferase 6Bprovided by HGNC
    Primary source
    HGNC:HGNC:17582
    See related
    Ensembl:ENSG00000156650 MIM:605880; AllianceGenome:HGNC:17582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    qkf; MORF; MOZ2; GTPTS; MYST4; ZC2HC6B; querkopf
    Summary
    The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 9.9), testis (RPKM 7.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KAT6B in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (74824936..75032624)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (75698186..75906154)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76585013..76792382)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3598 Neighboring gene VISTA enhancer hs1500 Neighboring gene family with sequence similarity 32 member C, pseudogene Neighboring gene MPRA-validated peak1017 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76555535-76556121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76584665-76585436 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76585437-76586208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2504 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76615828-76616038 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76630209-76630443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3601 Neighboring gene MPRA-validated peak1019 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3602 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76776654-76776821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76789883-76790382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3604 Neighboring gene small nucleolar RNA, C/D box 172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76817979-76818530 Neighboring gene dual specificity phosphatase 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76829139-76829638 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:76836023-76836606 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839152-76839713 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839714-76840274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76842102-76842602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76844610-76845110 Neighboring gene peptidylprolyl isomerase A pseudogene 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased MORF leads to prolonged endoplasmic reticulum stress in periodontitis-associated chronic inflammation. Xue P, et al. Cell Death Differ, 2016 Nov 1. PMID 27447113, Free PMC Article
    2. Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation. Klein BJ, et al. Nat Commun, 2019 Oct 17. PMID 31624313, Free PMC Article
    3. A novel pathogenic frameshift variant of KAT6B identified by clinical exome sequencing in a newborn with the Say-Barber-Biesecker-Young-Simpson syndrome. Mendez R, et al. Clin Dysmorphol, 2020 Jan. PMID 30921092
    4. Novel truncating variants expand the phenotypic spectrum of KAT6B-related disorders. Brea-Fernández A, et al. Am J Med Genet A, 2019 Feb. PMID 30569622
    5. A novel truncating variant within exon 7 of KAT6B associated with features of both Say-Barber-Bieseker-Young-Simpson syndrome and genitopatellar syndrome: Further evidence of a continuum in the clinical spectrum of KAT6B-related disorders. Marangi G, et al. Am J Med Genet A, 2018 Feb. PMID 29226580

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERalpha status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.
      Title: ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B.
    2. Clinical heterogeneity of polish patients with KAT6B-related disorder.
      Title: Clinical heterogeneity of polish patients with KAT6B-related disorder.
    3. Clinical features and underlying mechanisms of KAT6B disease in a Chinese boy.
      Title: Clinical features and underlying mechanisms of KAT6B disease in a Chinese boy.
    4. Novel variant in the KAT6B gene associated with Say Barber Biesecker Young Simpson.
      Title: Novel variant in the KAT6B gene associated with Say Barber Biesecker Young Simpson.
    5. MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.
      Title: MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain.
    6. XBP1-elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR-22/lncRNA/KAT6B-dependent NF-kappaB signalling.
      Title: XBP1-elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR-22/lncRNA/KAT6B-dependent NF-κB signalling.
    7. Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma.
      Title: Recurrent KAT6B/A::KANSL1 Fusions Characterize a Potentially Aggressive Uterine Sarcoma Morphologically Overlapping With Low-grade Endometrial Stromal Sarcoma.
    8. Novel variants in KAT6B spectrum of disorders expand our knowledge of clinical manifestations and molecular mechanisms.
      Title: Novel variants in KAT6B spectrum of disorders expand our knowledge of clinical manifestations and molecular mechanisms.
    9. Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma.
      Title: Low Expression of KAT6B May Affect Prognosis in Hepatocellular Carcinoma.
    10. High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis.
      Title: High methylation of lysine acetyltransferase 6B is associated with the Cobb angle in patients with congenital scoliosis.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Blepharophimosis - intellectual disability syndrome, SBBYS type
    MedGen: C1863557 OMIM: 603736 GeneReviews: KAT6B Disorders
    		not available
    Genitopatellar syndrome
    MedGen: C1853566 OMIM: 606170 GeneReviews: KAT6B Disorders
    		not available

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-04-25)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2018-04-25)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90335, KIAA0383, DKFZp313G1618

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K14 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of developmental process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone acetyltransferase KAT6B
    Names
    K(lysine) acetyltransferase 6B
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
    MOZ-related factor
    MYST histone acetyltransferase (monocytic leukemia) 4
    MYST-4
    histone acetyltransferase MORF
    histone acetyltransferase MOZ2
    histone acetyltransferase MYST4
    monocytic leukemia zinc finger protein-related factor
    NP_001243397.1
    NP_001243398.1
    NP_001357061.1
    NP_001357062.1
    NP_001357063.1
    NP_001357064.1
    NP_001357065.1
    NP_001357066.1
    NP_001357067.1
    NP_001357068.1
    NP_001357069.1
    NP_001357070.1
    NP_001357071.1
    NP_001357072.1
    NP_001357073.1
    NP_036462.2
    XP_005269721.1
    XP_016871493.1
    XP_047280867.1
    XP_047280868.1
    XP_047280869.1
    XP_047280871.1
    XP_047280872.1
    XP_047280873.1
    XP_047280874.1
    XP_047280875.1
    XP_047280876.1
    XP_047280877.1
    XP_047280878.1
    XP_047280879.1
    XP_047280880.1
    XP_047280882.1
    XP_047280883.1
    XP_047280884.1
    XP_047280885.1
    XP_054187567.1
    XP_054187568.1
    XP_054187569.1
    XP_054187570.1
    XP_054187571.1
    XP_054187572.1
    XP_054187573.1
    XP_054187574.1
    XP_054187575.1
    XP_054187576.1
    XP_054187577.1
    XP_054187578.1
    XP_054187579.1
    XP_054187580.1
    XP_054187581.1
    XP_054187582.1
    XP_054187583.1
    XP_054187584.1
    XP_054187585.1
    XP_054221326.1
    XP_054221327.1
    XP_054221328.1
    XP_054221329.1
    XP_054221330.1
    XP_054221331.1
    XP_054221332.1
    XP_054221333.1
    XP_054221334.1
    XP_054221335.1
    XP_054221336.1
    XP_054221337.1
    XP_054221338.1
    XP_054221339.1
    XP_054221340.1
    XP_054221341.1
    XP_054221342.1
    XP_054221343.1
    XP_054221344.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032048.1 RefSeqGene

      Range
      5188..211212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256468.2 → NP_001243397.1  histone acetyltransferase KAT6B isoform 2

      See identical proteins and their annotated locations for NP_001243397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
      Source sequence(s)
      AC018511, AF119230, AF217500, BC150618, DA488537
      Consensus CDS
      CCDS58085.1
      UniProtKB/TrEMBL
      A7E2B6
      Related
      ENSP00000361809.2, ENST00000372724.6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:538 → 806
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:212 → 270
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
      pfam05466
      Location:1252 → 1381
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    2. NM_001256469.2 → NP_001243398.1  histone acetyltransferase KAT6B isoform 3

      See identical proteins and their annotated locations for NP_001243398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Variants 3 and 11-14 all encode the same isoform (3).
      Source sequence(s)
      AC018511, AF113514, AF217500, BC150618, DA488537
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Related
      ENSP00000497048.1, ENST00000648892.1
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429 → 697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:1203 → 1459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212 → 270
      PHD_SF; PHD finger superfamily

    3. NM_001370132.1 → NP_001357061.1  histone acetyltransferase KAT6B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC018511, AC063962
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429 → 643
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:1089 → 1218
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl22851
      Location:212 → 270
      PHD_SF; PHD finger superfamily

    4. NM_001370133.1 → NP_001357062.1  histone acetyltransferase KAT6B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC018511, AC063962
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (4) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      cd15618
      Location:212 → 269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:872 → 1001
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam01853
      Location:283 → 390
      MOZ_SAS; MOZ/SAS family

    5. NM_001370134.1 → NP_001357063.1  histone acetyltransferase KAT6B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC018511, AC063962
      Conserved Domains (2) summary
      PLN00104
      Location:80 → 294
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam05466
      Location:740 → 869
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    6. NM_001370135.1 → NP_001357064.1  histone acetyltransferase KAT6B isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC018511, AC063962
      Conserved Domains (2) summary
      pfam05466
      Location:654 → 783
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam01853
      Location:65 → 172
      MOZ_SAS; MOZ/SAS family

    7. NM_001370136.1 → NP_001357065.1  histone acetyltransferase KAT6B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1 and 9, encodes isoform 1.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS7345.1
      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
      Related
      ENSP00000497166.1, ENST00000649463.1
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:212 → 269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:1435 → 1564
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    8. NM_001370137.1 → NP_001357066.1  histone acetyltransferase KAT6B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1 and 8, encodes isoform 1.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS7345.1
      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:212 → 269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:1435 → 1564
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    9. NM_001370138.1 → NP_001357067.1  histone acetyltransferase KAT6B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58085.1
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:538 → 806
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:212 → 270
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
      pfam05466
      Location:1252 → 1381
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    10. NM_001370139.1 → NP_001357068.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 3 and 12-14, encodes isoform 3.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429 → 697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:1203 → 1459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212 → 270
      PHD_SF; PHD finger superfamily

    11. NM_001370140.1 → NP_001357069.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 3, 11, 13, and 14, encodes isoform 3.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429 → 697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:1203 → 1459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212 → 270
      PHD_SF; PHD finger superfamily

    12. NM_001370141.1 → NP_001357070.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 3, 11, 12, and 14, encodes isoform 3.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Related
      ENSP00000361810.1, ENST00000372725.6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429 → 697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:1203 → 1459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212 → 270
      PHD_SF; PHD finger superfamily

    13. NM_001370142.1 → NP_001357071.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 3 and 11-13, encodes isoform 3.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Related
      ENSP00000361799.1, ENST00000372714.6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429 → 697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:1203 → 1459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212 → 270
      PHD_SF; PHD finger superfamily

    14. NM_001370143.1 → NP_001357072.1  histone acetyltransferase KAT6B isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform 8.
      Source sequence(s)
      AC018511, AC063962
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:366 → 634
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 309
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:1080 → 1209
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl22851
      Location:212 → 270
      PHD_SF; PHD finger superfamily

    15. NM_001370144.1 → NP_001357073.1  histone acetyltransferase KAT6B isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform 8.
      Source sequence(s)
      AC018511, AC063962
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:366 → 634
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 309
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:1080 → 1209
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl22851
      Location:212 → 270
      PHD_SF; PHD finger superfamily

    16. NM_012330.4 → NP_036462.2  histone acetyltransferase KAT6B isoform 1

      See identical proteins and their annotated locations for NP_036462.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 8, and 9 all encode the same isoform (1).
      Source sequence(s)
      AC018511, AF217500, BC014143, BC150618, DA488537
      Consensus CDS
      CCDS7345.1
      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
      Related
      ENSP00000287239.4, ENST00000287239.10
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:212 → 269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:1435 → 1564
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      74824936..75032624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424912.1 → XP_047280868.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

    2. XM_047424919.1 → XP_047280875.1  histone acetyltransferase KAT6B isoform X3

    3. XM_047424927.1 → XP_047280883.1  histone acetyltransferase KAT6B isoform X5

    4. XM_005269664.3 → XP_005269721.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_005269721.1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
      Related
      ENSP00000497841.1, ENST00000648725.1
      Conserved Domains (5) summary
      smart00526
      Location:113 → 167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271 → 317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:212 → 269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:1435 → 1564
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    5. XM_047424913.1 → XP_047280869.1  histone acetyltransferase KAT6B isoform X2

    6. XM_047424916.1 → XP_047280872.1  histone acetyltransferase KAT6B isoform X3

    7. XM_047424923.1 → XP_047280879.1  histone acetyltransferase KAT6B isoform X5

    8. XM_047424929.1 → XP_047280885.1  histone acetyltransferase KAT6B isoform X6

    9. XM_047424911.1 → XP_047280867.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

    10. XM_047424918.1 → XP_047280874.1  histone acetyltransferase KAT6B isoform X3

    11. XM_047424922.1 → XP_047280878.1  histone acetyltransferase KAT6B isoform X4

    12. XM_047424924.1 → XP_047280880.1  histone acetyltransferase KAT6B isoform X5

    13. XM_017016004.3 → XP_016871493.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8

    14. XM_047424920.1 → XP_047280876.1  histone acetyltransferase KAT6B isoform X4

    15. XM_047424928.1 → XP_047280884.1  histone acetyltransferase KAT6B isoform X6

    16. XM_047424917.1 → XP_047280873.1  histone acetyltransferase KAT6B isoform X3

    17. XM_047424926.1 → XP_047280882.1  histone acetyltransferase KAT6B isoform X5

    18. XM_047424915.1 → XP_047280871.1  histone acetyltransferase KAT6B isoform X2

    19. XM_047424921.1 → XP_047280877.1  histone acetyltransferase KAT6B isoform X4

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646202.1 Reference GRCh38.p14 PATCHES

      Range
      29342..237300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331598.1 → XP_054187573.1  histone acetyltransferase KAT6B isoform X3

    2. XM_054331592.1 → XP_054187567.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

    3. XM_054331596.1 → XP_054187571.1  histone acetyltransferase KAT6B isoform X2

    4. XM_054331605.1 → XP_054187580.1  histone acetyltransferase KAT6B isoform X5

    5. XM_054331610.1 → XP_054187585.1  histone acetyltransferase KAT6B isoform X6

    6. XM_054331593.1 → XP_054187568.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

    7. XM_054331600.1 → XP_054187575.1  histone acetyltransferase KAT6B isoform X3

    8. XM_054331608.1 → XP_054187583.1  histone acetyltransferase KAT6B isoform X5

    9. XM_054331594.1 → XP_054187569.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

    10. XM_054331601.1 → XP_054187576.1  histone acetyltransferase KAT6B isoform X3

    11. XM_054331604.1 → XP_054187579.1  histone acetyltransferase KAT6B isoform X4

    12. XM_054331606.1 → XP_054187581.1  histone acetyltransferase KAT6B isoform X5

    13. XM_054331595.1 → XP_054187570.1  histone acetyltransferase KAT6B isoform X2

    14. XM_054331602.1 → XP_054187577.1  histone acetyltransferase KAT6B isoform X4

    15. XM_054331609.1 → XP_054187584.1  histone acetyltransferase KAT6B isoform X6

    16. XM_054331599.1 → XP_054187574.1  histone acetyltransferase KAT6B isoform X3

    17. XM_054331607.1 → XP_054187582.1  histone acetyltransferase KAT6B isoform X5

    18. XM_054331597.1 → XP_054187572.1  histone acetyltransferase KAT6B isoform X2

    19. XM_054331603.1 → XP_054187578.1  histone acetyltransferase KAT6B isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      75698186..75906154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365357.1 → XP_054221332.1  histone acetyltransferase KAT6B isoform X3

    2. XM_054365351.1 → XP_054221326.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

    3. XM_054365355.1 → XP_054221330.1  histone acetyltransferase KAT6B isoform X2

    4. XM_054365364.1 → XP_054221339.1  histone acetyltransferase KAT6B isoform X5

    5. XM_054365369.1 → XP_054221344.1  histone acetyltransferase KAT6B isoform X6

    6. XM_054365352.1 → XP_054221327.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

    7. XM_054365359.1 → XP_054221334.1  histone acetyltransferase KAT6B isoform X3

    8. XM_054365367.1 → XP_054221342.1  histone acetyltransferase KAT6B isoform X5

    9. XM_054365353.1 → XP_054221328.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0

    10. XM_054365360.1 → XP_054221335.1  histone acetyltransferase KAT6B isoform X3

    11. XM_054365363.1 → XP_054221338.1  histone acetyltransferase KAT6B isoform X4

    12. XM_054365365.1 → XP_054221340.1  histone acetyltransferase KAT6B isoform X5

    13. XM_054365354.1 → XP_054221329.1  histone acetyltransferase KAT6B isoform X2

    14. XM_054365361.1 → XP_054221336.1  histone acetyltransferase KAT6B isoform X4

    15. XM_054365368.1 → XP_054221343.1  histone acetyltransferase KAT6B isoform X6

    16. XM_054365358.1 → XP_054221333.1  histone acetyltransferase KAT6B isoform X3

    17. XM_054365366.1 → XP_054221341.1  histone acetyltransferase KAT6B isoform X5

    18. XM_054365356.1 → XP_054221331.1  histone acetyltransferase KAT6B isoform X2

    19. XM_054365362.1 → XP_054221337.1  histone acetyltransferase KAT6B isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WYB5.3 GenPept UniProtKB/Swiss-Prot:Q8WYB5

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