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    Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 [ Mus musculus (house mouse) ]

    Gene ID: 238271, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcnh5provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily H (eag-related), member 5provided by MGI
    Primary source
    MGI:MGI:3584508
    See related
    Ensembl:ENSMUSG00000034402 AllianceGenome:MGI:3584508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eag2; mEag2
    Summary
    Predicted to enable delayed rectifier potassium channel activity and transmembrane transporter binding activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to act upstream of or within regulation of G2/M transition of mitotic cell cycle. Predicted to be located in cell surface. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood vessel; central nervous system; eye; genitourinary system; and thymus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human KCNH5 (potassium voltage-gated channel subfamily H member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.7), frontal lobe adult (RPKM 1.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnh5 in Genome Data Viewer
    Location:
    12 C3; 12 32.62 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (74943991..75224625, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (74897217..75177332, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53728 Neighboring gene STARR-seq mESC enhancer starr_32485 Neighboring gene STARR-seq mESC enhancer starr_32486 Neighboring gene STARR-seq mESC enhancer starr_32487 Neighboring gene predicted gene, 39473 Neighboring gene STARR-seq mESC enhancer starr_32489 Neighboring gene STARR-seq mESC enhancer starr_32490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76492550-76492789 Neighboring gene ras homolog family member J Neighboring gene predicted gene, 34613 Neighboring gene glycoprotein hormone beta 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Divalent cations slow activation of EAG family K+ channels through direct binding to S4. Zhang X, et al. Biophys J, 2009 Jul 8. PMID 19580749, Free PMC Article
    2. Conditional gene targeting on the pure C57BL/6 genetic background. Mishina M, et al. Neurosci Res, 2007 Jun. PMID 17298852
    3. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Huang X, et al. Genes Dev, 2012 Aug 15. PMID 22855790, Free PMC Article
    4. The transcription factor c-Maf controls touch receptor development and function. Wende H, et al. Science, 2012 Mar 16. PMID 22345400
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in intracellular anatomical structure ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated delayed rectifier potassium channel KCNH5; potassium voltage-gated channel subfamily H member 5
    Names
    ether-a-go-go potassium channel 2
    voltage-gated potassium channel subunit Kv10.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172805.3 → NP_766393.2  voltage-gated delayed rectifier potassium channel KCNH5

      See identical proteins and their annotated locations for NP_766393.2

      Status: VALIDATED

      Source sequence(s)
      AC110175, AC131762, AK032438, CT010432
      Consensus CDS
      CCDS25980.1
      UniProtKB/Swiss-Prot
      E9QPM0, Q8C035, Q920E3
      UniProtKB/TrEMBL
      Q6NZH0
      Related
      ENSMUSP00000046864.3, ENSMUST00000042299.4
      Conserved Domains (6) summary
      COG0664
      Location:544 → 723
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:550 → 660
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00130
      Location:37 → 131
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00520
      Location:232 → 479
      Ion_trans; Ion transport protein
      pfam07885
      Location:419 → 473
      Ion_trans_2; Ion channel
      pfam08447
      Location:40 → 127
      PAS_3; PAS fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      74943991..75224625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157403.1 → XP_036013296.1  potassium voltage-gated channel subfamily H member 5 isoform X1

      Conserved Domains (2) summary
      pfam00520
      Location:217 → 479
      Ion_trans; Ion transport protein
      pfam13426
      Location:39 → 132
      PAS_9; PAS domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920E3.3 GenPept UniProtKB/Swiss-Prot:Q920E3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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