ELAVL1 ELAV like RNA binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ELAVL1provided by HGNC
Official Full Name: ELAV like RNA binding protein 1provided by HGNC
Primary source: HGNC:HGNC:3312
See related: Ensembl:ENSG00000066044 MIM:603466; AllianceGenome:HGNC:3312
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HUR; Hua; MelG; ELAV1
Summary: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
Expression: Ubiquitous expression in testis (RPKM 14.6), brain (RPKM 9.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (7958573..8005641, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (7959562..8006636, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (8023457..8070525, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELAVL1 regulates glycolysis in nasopharyngeal carcinoma cells through the HMGB3/beta-catenin axis.
Title: ELAVL1 regulates glycolysis in nasopharyngeal carcinoma cells through the HMGB3/β-catenin axis.
ELAVL1 regulates PD-L1 mRNA stability to disrupt the infiltration of CD4-positive T cells in prostate cancer.
Title: ELAVL1 regulates PD-L1 mRNA stability to disrupt the infiltration of CD4-positive T cells in prostate cancer.
HuR promotes triglyceride synthesis and intestinal fat absorption.
Title: HuR promotes triglyceride synthesis and intestinal fat absorption.
HuR controls glutaminase RNA metabolism.
Title: HuR controls glutaminase RNA metabolism.
STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1beta-induced IL-8 production.
Title: STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1β-induced IL-8 production.
Increased expression of long non-coding RNA FIRRE promotes hepatocellular carcinoma by HuR-CyclinD1 axis signaling.
Title: Increased expression of long non-coding RNA FIRRE promotes hepatocellular carcinoma by HuR-CyclinD1 axis signaling.
Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders.
Title: Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders.
Human antigen R transfers miRNA to Syntaxin 5 to synergize miRNA export from activated macrophages.
Title: Human antigen R transfers miRNA to Syntaxin 5 to synergize miRNA export from activated macrophages.
HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p.
Title: HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p.
SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
Title: SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.

Submit: New GeneRIF Correction See all GeneRIFs (507)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify ELAV-like 1 protein (ELAVL1; Hu antigen R, HUR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify ELAV-like 1 protein (ELAVL1; Hu antigen R, HUR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify ELAV-like 1 protein (ELAVL1; Hu antigen R, HUR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify ELAV-like 1 protein (ELAVL1; Hu antigen R, HUR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
nucleocapsid	gag	HIV-1 NC upregulates ELAVL1 (embryonic lethal, abnormal vision, Drosophila)-like 1 in HEK 293T cells	PubMed
reverse transcriptase	gag-pol	No direct protein-protein interaction between purified full-length HuR and HIV-1 RT is detected using NMR titrations	PubMed
	gag-pol	HIV-1 RT heterodimer (p66/p51) interacts directly with HuR	PubMed
	gag-pol	HuR interacts with HIV-1 p66 reverse transcriptase. Amino acids 286-326 in the third RNA recognition domain of HuR and amino acids 482-539 in the RNase H domain of p66 RT are required for their interaction	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NIB1428 (e-PCR)
- UniSTS:80130

D19S847 (e-PCR)
- UniSTS:154131

D17S1185 (e-PCR)
- UniSTS:149797

D8S2279 (e-PCR)
- UniSTS:473907

A002V04 (e-PCR)
- UniSTS:57227

SHGC-34332 (e-PCR)
- UniSTS:45713

A002T18 (e-PCR)
- UniSTS:39595

D19S1135 (e-PCR)
- UniSTS:1729

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	TAS Traceable Author Statement more info	PubMed
enables miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in 3'-UTR-mediated mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lncRNA-mediated post-transcriptional gene silencing	IEA Inferred from Electronic Annotation more info
involved_in mRNA destabilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of miRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in regulation of stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ELAV-like protein 1

Names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Hu antigen R; Human antigen R; embryonic lethal, abnormal vision, drosophila, homolog-like 1; hu-antigen R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419.3 → NP_001410.2 ELAV-like protein 1

See identical proteins and their annotated locations for NP_001410.2

Status: REVIEWED

Source sequence(s)

AI375368, AL713686, AW139417, BC003376, BM664469, BM696191, BU542524, W37464

Consensus CDS

CCDS12193.1

UniProtKB/Swiss-Prot

B4DVB8, Q15717, Q53XN6, Q9BTT1

Related

ENSP00000385269.1, ENST00000407627.7

Conserved Domains (1) summary

TIGR01661
Location:19 → 326

ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

7958573..8005641 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438384.1 → XP_047294340.1 ELAV-like protein 1 isoform X2

UniProtKB/TrEMBL

M0QZR9
XM_047438383.1 → XP_047294339.1 ELAV-like protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

7959562..8006636 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320149.1 → XP_054176124.1 ELAV-like protein 1 isoform X2

UniProtKB/TrEMBL

M0QZR9
XM_054320148.1 → XP_054176123.1 ELAV-like protein 1 isoform X1