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    Fbxo21 F-box protein 21 [ Mus musculus (house mouse) ]

    Gene ID: 231670, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxo21provided by MGI
    Official Full Name
    F-box protein 21provided by MGI
    Primary source
    MGI:MGI:1924223
    See related
    Ensembl:ENSMUSG00000032898 AllianceGenome:MGI:1924223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810425J22Rik
    Summary
    Predicted to enable DNA binding activity. Is expressed in nervous system and neural retina. Orthologous to human FBXO21 (F-box protein 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 54.7), whole brain E14.5 (RPKM 49.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxo21 in Genome Data Viewer
    Location:
    5 F; 5 57.73 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118114835..118148263)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117976770..118010198)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Nos1 exon 2 regulatory region Neighboring gene predicted gene, 30360 Neighboring gene STARR-seq mESC enhancer starr_14186 Neighboring gene STARR-seq mESC enhancer starr_14187 Neighboring gene nitric oxide synthase 1, neuronal Neighboring gene predicted gene, 26995 Neighboring gene STARR-positive B cell enhancer ABC_E4781 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:118486912-118487121 Neighboring gene tescalcin Neighboring gene predicted gene 9754 Neighboring gene F-box and WD-40 domain protein 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346588.1NP_001333517.1  F-box only protein 21 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AK048131, AK049723, BE954194, BP754360, BY478760
      Consensus CDS
      CCDS84947.1
      UniProtKB/TrEMBL
      A0A0J9YU92
      Related
      ENSMUSP00000035506.8, ENSMUST00000035579.10
    2. NM_145564.4NP_663539.1  F-box only protein 21 isoform 1

      See identical proteins and their annotated locations for NP_663539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK049723, BP754360
      Consensus CDS
      CCDS19607.1
      UniProtKB/Swiss-Prot
      Q8BHA5, Q8CHC6, Q8VDH1
      UniProtKB/TrEMBL
      A0A0J9YU92
      Related
      ENSMUSP00000143873.2, ENSMUST00000202447.4
      Conserved Domains (3) summary
      TIGR02097
      Location:500597
      yccV; hemimethylated DNA binding domain
      pfam12937
      Location:3078
      F-box-like; F-box-like
      pfam13369
      Location:258388
      Transglut_core2; Transglutaminase-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      118114835..118148263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)