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    SSB small RNA binding exonuclease protection factor La [ Homo sapiens (human) ]

    Gene ID: 6741, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SSBprovided by HGNC
    Official Full Name
    small RNA binding exonuclease protection factor Laprovided by HGNC
    Primary source
    HGNC:HGNC:11316
    See related
    Ensembl:ENSG00000138385 MIM:109090; AllianceGenome:HGNC:11316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    La; LARP3; La/SSB
    Summary
    The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
    Expression
    Ubiquitous expression in fat (RPKM 51.7), thyroid (RPKM 36.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SSB in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (169798871..169812064)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (170276405..170289608)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170655381..170668574)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:170646034-170646713 Neighboring gene uncharacterized LOC124907905 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:170655164-170655664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12086 Neighboring gene cytochrome b5 type A pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:170681961-170682164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:170685725-170686226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:170686227-170686726 Neighboring gene methyltransferase 5, N6-adenosine Neighboring gene small nucleolar RNA, C/D box 3K Neighboring gene ReSE screen-validated silencer GRCh37_chr2:170696663-170696887 Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:170809766-170810965 Neighboring gene Sharpr-MPRA regulatory region 15130 Neighboring gene VISTA enhancer hs1867 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:170934286-170935065 Neighboring gene NSA2 pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein. Martino L, et al. Nucleic Acids Res, 2012 Feb. PMID 22009680, Free PMC Article
    2. [A study on the relativity between La protein and the stability of HBV mRNA and the expression of HBV protein]. Zhang H, et al. Zhonghua Gan Zang Bing Za Zhi, 2006 Oct. PMID 17064465
    3. Specific interaction of HeLa cell proteins with coxsackievirus B3 3'UTR: La autoantigen binds the 3' and 5'UTR independently of the poly(A) tail. Cheung P, et al. Cell Microbiol, 2007 Jul. PMID 17346312
    4. The La autoantigen is a malignancy-associated cell death target that is induced by DNA-damaging drugs. Al-Ejeh F, et al. Clin Cancer Res, 2007 Sep 15. PMID 17875783
    5. La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity. Huang M, et al. Life Sci, 2007 Oct 27. PMID 17945310

    See all (302) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis.
      Title: LARP3, LARP7, and MePCE are involved in the early stage of human telomerase RNA biogenesis.
    2. NMR Analysis Suggests Synergy between the RRM2 and the Carboxy-Terminal Segment of Human La Protein in the Recognition and Interaction with HCV IRES.
      Title: NMR Analysis Suggests Synergy between the RRM2 and the Carboxy-Terminal Segment of Human La Protein in the Recognition and Interaction with HCV IRES.
    3. Upregulated SSB Is Involved in Hepatocellular Carcinoma Progression and Metastasis through the Epithelial-Mesenchymal Transition, Antiapoptosis, and Altered ROS Level Pathway.
      Title: Upregulated SSB Is Involved in Hepatocellular Carcinoma Progression and Metastasis through the Epithelial-Mesenchymal Transition, Antiapoptosis, and Altered ROS Level Pathway.
    4. The RNA-binding protein La/SSB associates with radiation-induced DNA double-strand breaks in lung cancer cell lines.
      Title: The RNA-binding protein La/SSB associates with radiation-induced DNA double-strand breaks in lung cancer cell lines.
    5. RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA.
      Title: RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA.
    6. Sjogren Syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human.
      Title: Sjögren Syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human.
    7. Functional and Structural Aspects of La Protein Overexpression in Lung Cancer.
      Title: Functional and Structural Aspects of La Protein Overexpression in Lung Cancer.
    8. Data is consistent with human La functioning in translation through contacts to the poly(A) tail.
      Title: Human La binds mRNAs through contacts to the poly(A) tail.
    9. Sumoylation of La protein promotes cell proliferation by averting ubiquitination-mediated degradation of the STAT3 protein.
      Title: SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.
    10. A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA.
      Title: The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.
    Submit: New GeneRIF Correction See all GeneRIFs (78)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of Sjogren syndrome antigen B (SSB) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev is identified to have a physical interaction with Sjogren syndrome antigen B ( SSB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    rev HIV-1 Rev interacting protein, Sjogren syndrome antigen B (SSB), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SSB is increased by RRE PubMed
    Tat tat The La autoantigen binds to HIV-1 TAR RNA and alleviates translational repression by the HIV-1 leader RNA, suggesting a possible involvement of the La autoantigen in HIV-1 gene expression and Tat transactivation PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of Sjogren syndrome antigen B (SSB, autoantigen La) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human Sjogren syndrome antigen B (SSB; autoantigen La) at amino acid residues 24-25 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables poly(U) RNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in histone mRNA metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear histone mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lupus La protein
    Names
    La ribonucleoprotein domain family, member 3
    SS-B
    SS-B/La protein
    Sjogren syndrome antigen B
    autoantigen La
    la autoantigen
    lupus La antigen
    sjoegren syndrome type B antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030640.1 RefSeqGene

      Range
      5060..18253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001294145.2 → NP_001281074.1  lupus La protein

      See identical proteins and their annotated locations for NP_001281074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon and encodes the same protein, compared to variant 1.
      Source sequence(s)
      BC001289, X69804
      Consensus CDS
      CCDS2237.1
      UniProtKB/Swiss-Prot
      P05455, Q15367, Q53XJ4
      UniProtKB/TrEMBL
      B5BUB5
      Related
      ENSP00000386636.1, ENST00000409333.1
      Conserved Domains (3) summary
      cd08028
      Location:10 → 91
      LARP_3; La RNA-binding domain of La-related protein 3
      cd12291
      Location:112 → 183
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      pfam08777
      Location:231 → 334
      RRM_3; RNA binding motif

    2. NM_003142.5 → NP_003133.1  lupus La protein

      See identical proteins and their annotated locations for NP_003133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      BC001289, CD676196
      Consensus CDS
      CCDS2237.1
      UniProtKB/Swiss-Prot
      P05455, Q15367, Q53XJ4
      UniProtKB/TrEMBL
      B5BUB5
      Related
      ENSP00000260956.4, ENST00000260956.9
      Conserved Domains (3) summary
      cd08028
      Location:10 → 91
      LARP_3; La RNA-binding domain of La-related protein 3
      cd12291
      Location:112 → 183
      RRM1_La; RNA recognition motif 1 in La autoantigen (La or LARP3) and similar proteins
      pfam08777
      Location:231 → 334
      RRM_3; RNA binding motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      169798871..169812064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      170276405..170289608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05455.2 GenPept UniProtKB/Swiss-Prot:P05455

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools