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    SFRP2 secreted frizzled related protein 2 [ Homo sapiens (human) ]

    Gene ID: 6423, updated on 4-Jan-2025

    Summary

    Official Symbol
    SFRP2provided by HGNC
    Official Full Name
    secreted frizzled related protein 2provided by HGNC
    Primary source
    HGNC:HGNC:10777
    See related
    Ensembl:ENSG00000145423 MIM:604157; AllianceGenome:HGNC:10777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRP-2; SARP1; SDF-5
    Summary
    This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in urinary bladder (RPKM 276.9), gall bladder (RPKM 211.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See SFRP2 in Genome Data Viewer
    Location:
    4q31.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153780591..153789083, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (157105099..157113596, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154701743..154710235, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15767 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74840 Neighboring gene uncharacterized LOC105377499 Neighboring gene Sharpr-MPRA regulatory region 15425 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74848 Neighboring gene toll like receptor 2 Neighboring gene ring finger protein 175 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154710463-154711164 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154711165-154711866 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74856/74857 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154713271-154713972 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74859 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74875 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74882 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74898 Neighboring gene uncharacterized LOC101927947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74905 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74906 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74908 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:154802179-154802342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154855107-154855606 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:154871827-154872023 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:154908563-154909762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154944484-154945005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154945006-154945526 Neighboring gene Sharpr-MPRA regulatory region 8445 Neighboring gene MPRA-validated peak5134 silencer Neighboring gene dachsous cadherin-related 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22073 Neighboring gene kelch domain containing 4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (13 hits/1253 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Wnt-protein binding  
    enables Wnt-protein binding PubMed 
    enables endopeptidase activator activity  
    enables fibronectin binding  
    enables integrin binding  
    enables receptor ligand activity  
    Items 1 - 25 of 56
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    involved_in Wnt signaling pathway involved in somitogenesis  
    involved_in branching involved in blood vessel morphogenesis  
    involved_in canonical Wnt signaling pathway  
    involved_in cardiac left ventricle morphogenesis PubMed 
    involved_in cardiac muscle cell apoptotic process  
    involved_in cell-cell signaling  
    involved_in cellular response to X-ray  
    involved_in chondrocyte development  
    involved_in collagen fibril organization  
    involved_in convergent extension involved in axis elongation  
    involved_in digestive tract morphogenesis  
    involved_in embryonic digit morphogenesis  
    involved_in hematopoietic stem cell proliferation  
    involved_in male gonad development  
    involved_in mesodermal cell fate specification  
    involved_in negative regulation of BMP signaling pathway  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of Wnt signaling pathway PubMed 
    involved_in negative regulation of Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of dermatome development  
    involved_in negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
    involved_in negative regulation of mesodermal cell fate specification  
    involved_in negative regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in neural tube closure  
    involved_in non-canonical Wnt signaling pathway  
    involved_in outflow tract morphogenesis PubMed 
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell adhesion mediated by integrin  
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of fat cell differentiation PubMed 
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in post-anal tail morphogenesis  
    involved_in regulation of establishment of planar polarity  
    involved_in regulation of midbrain dopaminergic neuron differentiation  
    involved_in regulation of neuron projection development  
    involved_in regulation of stem cell division  
    involved_in response to nutrient  
    involved_in response to xenobiotic stimulus  
    involved_in sclerotome development  
    involved_in stem cell fate specification  
    Items 1 - 25 of 56
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  

    General protein information

    Preferred Names
    secreted frizzled-related protein 2
    Names
    SARP-1
    sFRP-2
    secreted apoptosis related protein 1
    testicular tissue protein Li 170

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046941.1 RefSeqGene

      Range
      4994..13486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003013.3 → NP_003004.1  secreted frizzled-related protein 2 precursor

      See identical proteins and their annotated locations for NP_003004.1

      Status: REVIEWED

      Source sequence(s)
      AA449032, AC020703, AF311912, AK075372, AK093922, BC008666, BM906663, BM924815, CN431016
      Consensus CDS
      CCDS34082.1
      UniProtKB/Swiss-Prot
      B3KQR2, O14778, Q96HF1, Q9HAP5
      UniProtKB/TrEMBL
      A0A140VJU3, B3KSM5
      Related
      ENSP00000274063.4, ENST00000274063.5
      Conserved Domains (2) summary
      cd07446
      Location:36 → 163
      CRD_SFRP2; Cysteine-rich domain of the secreted frizzled-related protein 2 (SFRP2), a regulator of Wnt activity
      cd03580
      Location:169 → 295
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      153780591..153789083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      157105099..157113596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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