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    KLC1 kinesin light chain 1 [ Homo sapiens (human) ]

    Gene ID: 3831, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KLC1provided by HGNC
    Official Full Name
    kinesin light chain 1provided by HGNC
    Primary source
    HGNC:HGNC:6387
    See related
    Ensembl:ENSG00000126214 MIM:600025; AllianceGenome:HGNC:6387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KLC; KNS2; KNS2A
    Summary
    Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 108.4), heart (RPKM 21.0) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KLC1 in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103629211..103701544)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97865285..97937591)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104095548..104167881)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 68, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr14:104054857-104055031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104056621-104057122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104057123-104057622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6161 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6162 Neighboring gene uncharacterized LOC105370688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104106328-104106828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6168 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104140157-104140656 Neighboring gene MPRA-validated peak2255 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104172251-104172810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104172811-104173372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104180589-104181274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104184511-104185021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104187639-104188139 Neighboring gene X-ray repair cross complementing 3 Neighboring gene zinc finger FYVE-type containing 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104209353-104210134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6175 Neighboring gene protein phosphatase 1 regulatory subunit 13B Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104260985-104261486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104261487-104261986 Neighboring gene small nucleolar RNA SNORD51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and genetic characterization of the human kinesin light-chain (KLC) gene. Cabeza-Arvelaiz Y, et al. DNA Cell Biol, 1993 Dec. PMID 8274221
    2. Association of a rare haplotype in Kinesin light chain 1 gene with age-related cataract in a han chinese population. Zhang L, et al. PLoS One, 2013. PMID 23776437, Free PMC Article
    3. Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier. Morihara T, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24497505, Free PMC Article
    4. Evaluation of the genetic variants of kinesin motor protein in ischemic stroke. Szolnoki Z, et al. J Stroke Cerebrovasc Dis, 2009 Sep-Oct. PMID 19717019
    5. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. Szolnoki Z, et al. Clin Biochem, 2009 May. PMID 19046961

    See all (142) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing.
      Title: Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing.
    2. Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
      Title: Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport.
    3. Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
      Title: Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
    4. LMTK2 binds to KLC1 to direct axonal transport of p35 and its loss may contribute to Alzheimer's disease.
      Title: LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.
    5. TGF-beta mediated pro-invasive activity was found to be dependent on KIF5B expression. In contrast, the epithelial differentiation factor and EMT suppressor prolactin (PRL) was found to repress KIF5B gene expression and KIF5B-Snail1 nuclear accumulation, but enhanced KLC1 gene expression and KIF5B-KLC1 interaction.
      Title: A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
    6. these studies demonstrate that kinesin 1 regulates ciliogenesis through CCDC28B
      Title: Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.
    7. extensive biochemical characterization of the KLC:JIP1 interaction, as well as identification of potential KLC1-binding partners, improves the understanding of how this growing family of cargos is recruited to kinesin1 by KLC1.
      Title: Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1).
    8. structural plasticity of the N-terminal capping helix might represent a structural determinant for TPR domain structural versatility in cargo binding
      Title: Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
    9. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients.
      Title: A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC.
    10. BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine.
      Title: BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: COA8

    Homology

    Clone Names

    • MGC15245

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress granule disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of kinesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane HDA PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin light chain 1
    Names
    kinesin 2 60/70kDa
    medulloblastoma antigen MU-MB-2.50
    NP_001123579.1
    NP_001381761.1
    NP_001381762.1
    NP_001381763.1
    NP_001381764.1
    NP_001381765.1
    NP_001381766.1
    NP_001381767.1
    NP_001381768.1
    NP_001381769.1
    NP_001381770.1
    NP_001381771.1
    NP_001381772.1
    NP_001381773.1
    NP_001381774.1
    NP_001381775.1
    NP_001381776.1
    NP_001381777.1
    NP_001381778.1
    NP_001381779.1
    NP_001381780.1
    NP_001381781.1
    NP_001381782.1
    NP_001381783.1
    NP_001381784.1
    NP_001381785.1
    NP_001381786.1
    NP_001381787.1
    NP_001381788.1
    NP_001381789.1
    NP_005543.2
    NP_891553.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012307.1 RefSeqGene

      Range
      5024..77357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130107.2 → NP_001123579.1  kinesin light chain 1 isoform 3

      See identical proteins and their annotated locations for NP_001123579.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform 3, also known as D.
      Source sequence(s)
      BC008881, BK001163, BK001164, BM988840, BP274336
      Consensus CDS
      CCDS45168.1
      UniProtKB/TrEMBL
      Q7RTQ2
      Related
      ENSP00000414982.2, ENST00000452929.6
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    2. NM_001394832.1 → NP_001381761.1  kinesin light chain 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ4
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    3. NM_001394833.1 → NP_001381762.1  kinesin light chain 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTP8
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    4. NM_001394834.1 → NP_001381763.1  kinesin light chain 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ4
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    5. NM_001394835.1 → NP_001381764.1  kinesin light chain 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ0
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    6. NM_001394836.1 → NP_001381765.1  kinesin light chain 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ2
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    7. NM_001394837.1 → NP_001381766.1  kinesin light chain 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91953.1
      UniProtKB/TrEMBL
      Q7RTQ4
      Related
      ENSP00000334523.6, ENST00000334553.11
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    8. NM_001394838.1 → NP_001381767.1  kinesin light chain 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91952.1
      UniProtKB/TrEMBL
      Q7RTP8
      Related
      ENSP00000246489.7, ENST00000246489.11
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    9. NM_001394839.1 → NP_001381768.1  kinesin light chain 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ2
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    10. NM_001394840.1 → NP_001381769.1  kinesin light chain 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91948.1
      UniProtKB/TrEMBL
      G3V5R9, Q7RTQ4
      Related
      ENSP00000452481.1, ENST00000555836.5
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    11. NM_001394841.1 → NP_001381770.1  kinesin light chain 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91947.1
      UniProtKB/TrEMBL
      Q7RTQ0
      Related
      ENSP00000334618.7, ENST00000347839.10
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    12. NM_001394842.1 → NP_001381771.1  kinesin light chain 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ2
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:296 → 324
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:295 → 369
      TPR_12; Tetratricopeptide repeat

    13. NM_001394843.1 → NP_001381772.1  kinesin light chain 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ2
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 368
      TPR_12; Tetratricopeptide repeat

    14. NM_001394844.1 → NP_001381773.1  kinesin light chain 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91949.1
      UniProtKB/TrEMBL
      G3V3H3, Q7RTQ2
      Related
      ENSP00000451242.1, ENST00000554280.5
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    15. NM_001394845.1 → NP_001381774.1  kinesin light chain 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ1
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    16. NM_001394846.1 → NP_001381775.1  kinesin light chain 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      B5BU63
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    17. NM_001394847.1 → NP_001381776.1  kinesin light chain 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ2
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    18. NM_001394848.1 → NP_001381777.1  kinesin light chain 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      B5BU63
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    19. NM_001394849.1 → NP_001381778.1  kinesin light chain 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ7
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    20. NM_001394850.1 → NP_001381779.1  kinesin light chain 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91946.1
      UniProtKB/TrEMBL
      F8W6L3, Q7RTQ9
      Related
      ENSP00000369377.3, ENST00000380038.7
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    21. NM_001394851.1 → NP_001381780.1  kinesin light chain 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      B5BU63
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 368
      TPR_12; Tetratricopeptide repeat

    22. NM_001394852.1 → NP_001381781.1  kinesin light chain 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91950.1
      UniProtKB/TrEMBL
      B5BU63
      Related
      ENSP00000450648.1, ENST00000557450.5
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    23. NM_001394853.1 → NP_001381782.1  kinesin light chain 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ9
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    24. NM_001394854.1 → NP_001381783.1  kinesin light chain 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ7
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    25. NM_001394855.1 → NP_001381784.1  kinesin light chain 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ9
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    26. NM_001394856.1 → NP_001381785.1  kinesin light chain 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ9
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    27. NM_001394857.1 → NP_001381786.1  kinesin light chain 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91945.1
      UniProtKB/TrEMBL
      G5E9S8, Q7RTQ9
      Related
      ENSP00000412693.4, ENST00000445352.8
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 368
      TPR_12; Tetratricopeptide repeat

    28. NM_001394858.1 → NP_001381787.1  kinesin light chain 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ9
      Related
      ENSP00000488938.1, ENST00000634686.1
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    29. NM_001394859.1 → NP_001381788.1  kinesin light chain 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      UniProtKB/TrEMBL
      Q7RTQ9
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    30. NM_001394860.1 → NP_001381789.1  kinesin light chain 1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AL049840, AL139300
      Consensus CDS
      CCDS91951.1
      UniProtKB/TrEMBL
      G3V2E7, Q7RTQ7
      Related
      ENSP00000450617.1, ENST00000557575.5
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    31. NM_005552.5 → NP_005543.2  kinesin light chain 1 isoform 1

      See identical proteins and their annotated locations for NP_005543.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has an alternate 3' sequence, as compared to variant 3. The resulting isoform (1, also known as C) has a shorter and distinct C-terminus, as compared to isoform 3.
      Source sequence(s)
      AL049840, BC008881, DA501532
      Consensus CDS
      CCDS32165.1
      UniProtKB/TrEMBL
      Q7RTQ7
      Related
      ENSP00000374394.3, ENST00000389744.8
      Conserved Domains (3) summary
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat
      cl25732
      Location:35 → 149
      SMC_N; RecF/RecN/SMC N terminal domain

    32. NM_182923.4 → NP_891553.2  kinesin light chain 1 isoform 2

      See identical proteins and their annotated locations for NP_891553.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 3. The resulting isoform (2, also known as H) has a shorter and distinct C-terminus when compared to isoform 3.
      Source sequence(s)
      AL139300, BM988840, BP274336, L04733
      Consensus CDS
      CCDS41996.1
      UniProtKB/Swiss-Prot
      A6NF62, F8VTM4, Q07866, Q7RTM2, Q7RTM3, Q7RTM5, Q7RTP9, Q7RTQ3, Q7RTQ5, Q7RTQ6, Q86SF5, Q86TF5, Q86V74, Q86V75, Q86V76, Q86V77, Q86V78, Q86V79, Q96H62
      UniProtKB/TrEMBL
      B5BU63
      Related
      ENSP00000341154.6, ENST00000348520.10
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 149
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:297 → 325
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:296 → 370
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      103629211..103701544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      97865285..97937591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07866.2 GenPept UniProtKB/Swiss-Prot:Q07866

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials