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    Ido2 indoleamine 2,3-dioxygenase 2 [ Mus musculus (house mouse) ]

    Gene ID: 209176, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ido2provided by MGI
    Official Full Name
    indoleamine 2,3-dioxygenase 2provided by MGI
    Primary source
    MGI:MGI:2142489
    See related
    Ensembl:ENSMUSG00000031549 AllianceGenome:MGI:2142489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ido-2; Indol1; C230043N17Rik
    Summary
    Enables indoleamine 2,3-dioxygenase activity. Acts upstream of or within tryptophan catabolic process to kynurenine. Located in cytoplasm. Is expressed in corpus striatum. Orthologous to human IDO2 (indoleamine 2,3-dioxygenase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 13.5), genital fat pad adult (RPKM 2.6) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Ido2 in Genome Data Viewer
    Location:
    8 A2; 8 12.58 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25021908..25066430, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (24531892..24576414, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30845 Neighboring gene RIKEN cDNA 9130214F15 gene Neighboring gene STARR-seq mESC enhancer starr_20944 Neighboring gene STARR-seq mESC enhancer starr_20946 Neighboring gene STARR-seq mESC enhancer starr_20947 Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene predicted gene, 51565 Neighboring gene a disintegrin and metallopeptidase domain 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Therapeutic antibody targeting of indoleamine-2,3-dioxygenase (IDO2) inhibits autoimmune arthritis. Merlo LMF, et al. Clin Immunol, 2017 Jun. PMID 28223071, Free PMC Article
    2. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Katz JB, et al. Immunol Rev, 2008 Apr. PMID 18364004
    3. Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. Ball HJ, et al. Int J Biochem Cell Biol, 2009 Mar. PMID 18282734
    4. Differential expression and regulation of Ido2 in the mouse uterus during peri-implantation period. Li DD, et al. In Vitro Cell Dev Biol Anim, 2015 Mar. PMID 25408380
    5. Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth. Liu Y, et al. Oncotarget, 2016 May 31. PMID 27058624, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction.
      Title: Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction.
    2. Absence of indoleamine 2,3dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
      Title: Absence of indoleamine 2,3‑dioxygenase 2 promotes liver regeneration after partial hepatectomy in mice.
    3. The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism.
      Title: The Immunomodulatory Enzyme IDO2 Mediates Autoimmune Arthritis through a Nonenzymatic Mechanism.
    4. Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses.
      Title: Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses.
    5. Data showed that Ido2 depletion in immune cells effectively reduces lung cancer burden, indicating that Ido2 plays an important role in tumor progression and an important immune regulator in the tumor microenvironment.
      Title: Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma.
    6. The current study shows that the Ido1 and Ido2 genes are imprinted and maternally expressed in mouse placentas. DNA methylation analysis demonstrates that nine CpG sites at the Ido1 promoter constitute a differentially methylated region that is highly methylated in sperm but unmethylated in oocytes
      Title: Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss.
    7. IDO2-shRNA treatment also decreased the percentage of Tregs and T cell apoptosis in draining lymph nodes
      Title: [Knockdown of indoleamine 2, 3-dioxygenase 2 (IDO2)gene inhibits tumor growth and enhances immune function in mice bearing melanoma].
    8. IDO is a critical regulator of acute pulmonary inflammation.
      Title: Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway.
    9. Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.
      Title: Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.
    10. Findings suggest non-redundant neurophysiological roles for indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2 and tryptophan 2,3-dioxygenase in modulating brain activities and metabolism.
      Title: Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31194

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables indoleamine 2,3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables indoleamine 2,3-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables indoleamine 2,3-dioxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables indoleamine 2,3-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan 2,3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan 2,3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tryptophan catabolic process to kynurenine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tryptophan catabolic process to kynurenine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tryptophan catabolic process to kynurenine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    indoleamine 2,3-dioxygenase 2
    Names
    indoleamine 2,3-dioxygenase-like protein 1
    indoleamine-pyrrole 2,3 dioxygenase-like 1
    NP_666061.3
    XP_006509109.1
    XP_006509110.1
    XP_006509111.1
    XP_011240433.1
    XP_030099238.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145949.2 → NP_666061.3  indoleamine 2,3-dioxygenase 2

      See identical proteins and their annotated locations for NP_666061.3

      Status: VALIDATED

      Source sequence(s)
      AC114602, BX637885, EF137182
      Consensus CDS
      CCDS40298.2
      UniProtKB/Swiss-Prot
      A4UHF3, E9QKA9, Q8R0V5
      Related
      ENSMUSP00000113979.2, ENSMUST00000121992.2
      Conserved Domains (1) summary
      pfam01231
      Location:15 → 399
      IDO; Indoleamine 2,3-dioxygenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25021908..25066430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509046.5 → XP_006509109.1  indoleamine 2,3-dioxygenase 2 isoform X1

      Conserved Domains (1) summary
      pfam01231
      Location:38 → 367
      IDO; Indoleamine 2,3-dioxygenase

    2. XM_006509047.4 → XP_006509110.1  indoleamine 2,3-dioxygenase 2 isoform X2

      See identical proteins and their annotated locations for XP_006509110.1

      Conserved Domains (1) summary
      pfam01231
      Location:1 → 334
      IDO; Indoleamine 2,3-dioxygenase

    3. XM_006509048.2 → XP_006509111.1  indoleamine 2,3-dioxygenase 2 isoform X2

      See identical proteins and their annotated locations for XP_006509111.1

      Related
      ENSMUST00000140417.9
      Conserved Domains (1) summary
      pfam01231
      Location:1 → 334
      IDO; Indoleamine 2,3-dioxygenase

    4. XM_030243378.1 → XP_030099238.1  indoleamine 2,3-dioxygenase 2 isoform X3

      Conserved Domains (1) summary
      cl21721
      Location:18 → 240
      IDO; Indoleamine 2,3-dioxygenase

    5. XM_011242131.4 → XP_011240433.1  indoleamine 2,3-dioxygenase 2 isoform X4

      Conserved Domains (1) summary
      cl21721
      Location:18 → 240
      IDO; Indoleamine 2,3-dioxygenase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0V5.3 GenPept UniProtKB/Swiss-Prot:Q8R0V5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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