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    Ccnf cyclin F [ Mus musculus (house mouse) ]

    Gene ID: 12449, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccnfprovided by MGI
    Official Full Name
    cyclin Fprovided by MGI
    Primary source
    MGI:MGI:102551
    See related
    Ensembl:ENSMUSG00000072082 AllianceGenome:MGI:102551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CycF; Fbxo1
    Summary
    Predicted to enable anaphase-promoting complex binding activity and cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within negative regulation of centrosome duplication; placenta development; and re-entry into mitotic cell cycle. Predicted to be located in cell junction; centriole; and centrosome. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in liver lobe; midbrain ventricular layer; and telencephalon. Orthologous to human CCNF (cyclin F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 29.9), thymus adult (RPKM 27.8) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ccnf in Genome Data Viewer
    Location:
    17 A3.3; 17 12.32 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24441518..24470333, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24223230..24251409, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 24 Neighboring gene STARR-positive B cell enhancer ABC_E2472 Neighboring gene netrin 3 Neighboring gene tubulin epsilon and delta complex 2 Neighboring gene STARR-seq mESC enhancer starr_42081 Neighboring gene microRNA 5134 Neighboring gene STARR-seq mESC enhancer starr_42082 Neighboring gene microRNA 6965 Neighboring gene ATP-binding cassette, sub-family A member 17 Neighboring gene STARR-seq mESC enhancer starr_42083 Neighboring gene STARR-positive B cell enhancer ABC_E9436 Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene predicted gene, 25618

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables anaphase-promoting complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of centrosome duplication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within re-entry into mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cyclin-F
    Names
    G2/mitotic-specific cyclin-F

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409800.1NP_001396729.1  cyclin-F isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117577
    2. NM_001409801.1NP_001396730.1  cyclin-F isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117577
    3. NM_001409803.1NP_001396732.1  cyclin-F isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117577
    4. NM_001409804.1NP_001396733.1  cyclin-F isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC117577
    5. NM_001409805.1NP_001396734.1  cyclin-F isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC117577
    6. NM_001409806.1NP_001396735.1  cyclin-F isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC117577
    7. NM_001409807.1NP_001396736.1  cyclin-F isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC117577
    8. NM_001409808.1NP_001396737.1  cyclin-F isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC117577
    9. NM_001409809.1NP_001396738.1  cyclin-F isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117577
    10. NM_001409832.1NP_001396761.1  cyclin-F isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC117577
    11. NM_007634.5NP_031660.3  cyclin-F isoform 4

      See identical proteins and their annotated locations for NP_031660.3

      Status: VALIDATED

      Source sequence(s)
      AC117577
      Consensus CDS
      CCDS37484.1
      UniProtKB/Swiss-Prot
      P51944, Q3TF73, Q60797, Q60799, Q8BSX9, Q8C4D9, Q8CI26
      Related
      ENSMUSP00000111048.4, ENSMUST00000115390.5
      Conserved Domains (3) summary
      smart00256
      Location:3573
      FBOX; A Receptor for Ubiquitination Targets
      pfam00134
      Location:281406
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:425531
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24441518..24470333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)