U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Sox17 SRY (sex determining region Y)-box 17 [ Mus musculus (house mouse) ]

    Gene ID: 20671, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sox17provided by MGI
    Official Full Name
    SRY (sex determining region Y)-box 17provided by MGI
    Primary source
    MGI:MGI:107543
    See related
    Ensembl:ENSMUSG00000025902 AllianceGenome:MGI:107543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a member of the Sox (Sry-related high mobility group box) family of transcription factors involved in the regulation of embryonic development. The encoded protein plays a role in the determination of cell fate and in maintaining cell identity. This gene regulates tumor angiogenesis and tumor progression. Mutations in the human gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Broad expression in ovary adult (RPKM 33.5), lung adult (RPKM 29.7) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sox17 in Genome Data Viewer
    Location:
    1 A1; 1 1.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4561154..4567624, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4490928..4497426, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00012 Neighboring gene STARR-seq mESC enhancer starr_00013 Neighboring gene STARR-seq mESC enhancer starr_00014 Neighboring gene predicted gene, 27396 Neighboring gene STARR-seq mESC enhancer starr_00015 Neighboring gene STARR-seq mESC enhancer starr_00016 Neighboring gene STARR-seq mESC enhancer starr_00017 Neighboring gene STARR-seq mESC enhancer starr_00018 Neighboring gene STARR-seq mESC enhancer starr_00019 Neighboring gene STARR-seq mESC enhancer starr_00020 Neighboring gene STARR-seq mESC enhancer starr_00021 Neighboring gene STARR-seq mESC enhancer starr_00022 Neighboring gene STARR-seq mESC enhancer starr_00023 Neighboring gene STARR-seq mESC enhancer starr_00024 Neighboring gene STARR-seq mESC enhancer starr_00025 Neighboring gene STARR-seq mESC enhancer starr_00026 Neighboring gene STARR-seq mESC enhancer starr_00027 Neighboring gene STARR-seq mESC enhancer starr_00028 Neighboring gene retinitis pigmentosa 1 (human) Neighboring gene STARR-seq mESC enhancer starr_00029 Neighboring gene actinin alpha 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00031 Neighboring gene STARR-seq mESC enhancer starr_00033 Neighboring gene STARR-seq mESC enhancer starr_00034 Neighboring gene predicted gene, 22307 Neighboring gene Moloney leukemia virus 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables beta-catenin binding PubMed 
    enables beta-catenin binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding PubMed 
    Items 1 - 25 of 72
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in angiogenesis  
    acts_upstream_of_or_within angiogenesis PubMed 
    involved_in cardiac cell fate determination  
    involved_in cardiac cell fate determination  
    involved_in cardiogenic plate morphogenesis PubMed 
    acts_upstream_of_or_within cell migration involved in gastrulation PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor PubMed 
    acts_upstream_of_or_within common bile duct development PubMed 
    acts_upstream_of_or_within embryonic foregut morphogenesis PubMed 
    involved_in embryonic foregut morphogenesis PubMed 
    acts_upstream_of_or_within embryonic heart tube development PubMed 
    involved_in embryonic heart tube morphogenesis PubMed 
    acts_upstream_of_or_within embryonic organ development PubMed 
    acts_upstream_of_or_within endocardial cell differentiation PubMed 
    acts_upstream_of_or_within endocardium formation PubMed 
    acts_upstream_of_or_within endoderm development PubMed 
    involved_in endoderm development PubMed 
    involved_in endoderm formation  
    involved_in endoderm formation  
    acts_upstream_of endodermal cell differentiation PubMed 
    acts_upstream_of_or_within endodermal cell fate determination PubMed 
    involved_in endodermal cell fate specification PubMed 
    involved_in endodermal digestive tract morphogenesis PubMed 
    acts_upstream_of_or_within gallbladder development PubMed 
    acts_upstream_of_or_within gastrulation PubMed 
    acts_upstream_of gene expression PubMed 
    involved_in heart development  
    involved_in heart development PubMed 
    acts_upstream_of_or_within heart looping PubMed 
    involved_in heart looping PubMed 
    acts_upstream_of_or_within inner cell mass cellular morphogenesis PubMed 
    involved_in metanephros development  
    involved_in metanephros development  
    involved_in negative regulation of Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in outflow tract morphogenesis PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of endodermal cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in positive regulation of protein catabolic process PubMed 
    acts_upstream_of_or_within positive regulation of stem cell differentiation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein destabilization  
    involved_in protein destabilization  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of cardiac cell fate specification PubMed 
    acts_upstream_of_or_within regulation of cell differentiation PubMed 
    involved_in regulation of embryonic development PubMed 
    acts_upstream_of_or_within regulation of stem cell division PubMed 
    acts_upstream_of_or_within regulation of stem cell proliferation PubMed 
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to alkaloid  
    acts_upstream_of_or_within rostrocaudal neural tube patterning PubMed 
    acts_upstream_of_or_within signal transduction involved in regulation of gene expression PubMed 
    acts_upstream_of_or_within spermatogenesis PubMed 
    acts_upstream_of stem cell differentiation PubMed 
    acts_upstream_of_or_within stem cell differentiation PubMed 
    acts_upstream_of_or_within stem cell fate specification PubMed 
    involved_in ureter development  
    involved_in ureter development  
    involved_in vasculogenesis  
    acts_upstream_of_or_within vasculogenesis PubMed 
    Items 1 - 25 of 72
    Component Evidence Code Pubs
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    transcription factor SOX-17
    Names
    SRY-box containing gene 17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289464.2NP_001276393.1  transcription factor SOX-17 isoform a

      See identical proteins and their annotated locations for NP_001276393.1

      Status: REVIEWED

      Source sequence(s)
      AC129937
      Consensus CDS
      CCDS14805.1
      UniProtKB/Swiss-Prot
      Q61472, Q61473, Q62248
      Related
      ENSMUSP00000112351.3, ENSMUST00000116652.8
      Conserved Domains (2) summary
      cd01388
      Location:67138
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam12067
      Location:203253
      Sox17_18_mid; Sox 17/18 central domain
    2. NM_001289465.2NP_001276394.1  transcription factor SOX-17 isoform b

      See identical proteins and their annotated locations for NP_001276394.1

      Status: REVIEWED

      Source sequence(s)
      AC129937
      Consensus CDS
      CCDS78539.1
      UniProtKB/TrEMBL
      A0A0A6YXS3
      Related
      ENSMUSP00000142116.2, ENSMUST00000192650.6
      Conserved Domains (2) summary
      pfam12067
      Location:137352
      Sox_C_TAD; Sox C-terminal transactivation domain
      cl00082
      Location:3873
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    3. NM_001289466.2NP_001276395.1  transcription factor SOX-17 isoform b

      See identical proteins and their annotated locations for NP_001276395.1

      Status: REVIEWED

      Source sequence(s)
      AC129937
      Consensus CDS
      CCDS78539.1
      UniProtKB/TrEMBL
      A0A0A6YXS3
      Conserved Domains (2) summary
      pfam12067
      Location:137352
      Sox_C_TAD; Sox C-terminal transactivation domain
      cl00082
      Location:3873
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    4. NM_001289467.2NP_001276396.1  transcription factor SOX-17 isoform c

      See identical proteins and their annotated locations for NP_001276396.1

      Status: REVIEWED

      Source sequence(s)
      AC129937
      Consensus CDS
      CCDS78538.1
      UniProtKB/Swiss-Prot
      Q61473
      Related
      ENSMUSP00000141894.2, ENSMUST00000195555.2
      Conserved Domains (1) summary
      pfam12067
      Location:74289
      Sox_C_TAD; Sox C-terminal transactivation domain
    5. NM_001420508.1NP_001407437.1  transcription factor SOX-17 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC129937
      UniProtKB/Swiss-Prot
      Q61472, Q61473, Q62248
    6. NM_001420509.1NP_001407438.1  transcription factor SOX-17 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC129937
      UniProtKB/Swiss-Prot
      Q61472, Q61473, Q62248
    7. NM_011441.6NP_035571.1  transcription factor SOX-17 isoform a

      See identical proteins and their annotated locations for NP_035571.1

      Status: REVIEWED

      Source sequence(s)
      AC129937
      Consensus CDS
      CCDS14805.1
      UniProtKB/Swiss-Prot
      Q61472, Q61473, Q62248
      Related
      ENSMUSP00000027035.4, ENSMUST00000027035.10
      Conserved Domains (2) summary
      cd01388
      Location:67138
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam12067
      Location:203253
      Sox17_18_mid; Sox 17/18 central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      4561154..4567624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162991.1XP_036018884.1  transcription factor SOX-17 isoform X1

      UniProtKB/Swiss-Prot
      Q61472, Q61473, Q62248
      Conserved Domains (2) summary
      cd01388
      Location:67138
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam12067
      Location:203253
      Sox17_18_mid; Sox 17/18 central domain
    2. XM_030252405.1XP_030108265.1  transcription factor SOX-17 isoform X1

      UniProtKB/Swiss-Prot
      Q61472, Q61473, Q62248
      Conserved Domains (2) summary
      cd01388
      Location:67138
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam12067
      Location:203253
      Sox17_18_mid; Sox 17/18 central domain
    3. XM_036162992.1XP_036018885.1  transcription factor SOX-17 isoform X2

      Conserved Domains (2) summary
      pfam12067
      Location:104154
      Sox17_18_mid; Sox 17/18 central domain
      cl00082
      Location:739
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    External link. Please review our privacy policy.