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    Pde2a phosphodiesterase 2A, cGMP-stimulated [ Mus musculus (house mouse) ]

    Gene ID: 207728, updated on 27-Dec-2024

    Summary

    Official Symbol
    Pde2aprovided by MGI
    Official Full Name
    phosphodiesterase 2A, cGMP-stimulatedprovided by MGI
    Primary source
    MGI:MGI:2446107
    See related
    Ensembl:ENSMUSG00000030653 Ensembl:ENSMUSG00000110195 AllianceGenome:MGI:2446107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cGSPDE; CGS-PDE
    Summary
    Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; GAF domain binding activity; and cyclic nucleotide binding activity. Involved in several processes, including cGMP catabolic process; cellular response to mechanical stimulus; and negative regulation of cGMP-mediated signaling. Acts upstream of or within circulatory system development and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including mitochondrion; perinuclear region of cytoplasm; and presynaptic membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and sensory organ. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 43.4), cortex adult (RPKM 43.1) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Pde2a in Genome Data Viewer
    Location:
    7 E2; 7 54.57 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101070905..101162026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101421691..101512829)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene StAR related lipid transfer domain containing 10 Neighboring gene predicted gene 20476 Neighboring gene STARR-seq mESC enhancer starr_19692 Neighboring gene predicted gene, 35219 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E4957 Neighboring gene STARR-positive B cell enhancer ABC_E1740 Neighboring gene microRNA 139 Neighboring gene predicted gene, 35363 Neighboring gene STARR-positive B cell enhancer ABC_E6576 Neighboring gene STARR-seq mESC enhancer starr_19694 Neighboring gene predicted gene, 19765 Neighboring gene ADP-ribosyltransferase 2a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC102210

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity  
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity  
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity PubMed 
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity  
    enables 3',5'-cyclic-AMP phosphodiesterase activity  
    enables 3',5'-cyclic-AMP phosphodiesterase activity PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity  
    enables 3',5'-cyclic-AMP phosphodiesterase activity  
    enables 3',5'-cyclic-GMP phosphodiesterase activity  
    enables 3',5'-cyclic-GMP phosphodiesterase activity PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity  
    enables 3',5'-cyclic-GMP phosphodiesterase activity  
    enables GAF domain binding PubMed 
    enables TPR domain binding  
    enables cAMP binding PubMed 
    enables cAMP binding  
    enables cGMP binding PubMed 
    enables cGMP binding PubMed 
    enables cGMP binding  
    enables identical protein binding  
    enables magnesium ion binding  
    enables metal ion binding  
    enables phosphate ion binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity PubMed 
    enables protein homodimerization activity  
    enables zinc ion binding  
    Items 1 - 25 of 27
    Items 1 - 25 of 55
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within aorta development PubMed 
    involved_in cAMP-mediated signaling  
    involved_in cAMP-mediated signaling  
    involved_in cAMP-mediated signaling PubMed 
    involved_in cGMP catabolic process  
    involved_in cGMP catabolic process PubMed 
    involved_in cGMP catabolic process  
    involved_in cGMP catabolic process  
    involved_in cGMP-mediated signaling  
    involved_in cGMP-mediated signaling PubMed 
    involved_in cGMP-mediated signaling  
    involved_in cGMP-mediated signaling  
    involved_in cGMP-mediated signaling PubMed 
    acts_upstream_of_or_within cardiac septum development PubMed 
    involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine  
    involved_in cellular response to cAMP  
    involved_in cellular response to cGMP  
    involved_in cellular response to cGMP  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus  
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to macrophage colony-stimulating factor stimulus  
    involved_in cellular response to macrophage colony-stimulating factor stimulus  
    involved_in cellular response to mechanical stimulus PubMed 
    acts_upstream_of_or_within coronary vasculature development PubMed 
    involved_in establishment of endothelial barrier  
    involved_in establishment of endothelial barrier  
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within heart valve development PubMed 
    involved_in intracellular signal transduction PubMed 
    involved_in intracellular signal transduction  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in negative regulation of cAMP-mediated signaling  
    involved_in negative regulation of cAMP-mediated signaling  
    involved_in negative regulation of cGMP-mediated signaling  
    involved_in negative regulation of cGMP-mediated signaling PubMed 
    involved_in negative regulation of oxidative phosphorylation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of vascular permeability  
    involved_in negative regulation of vascular permeability  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of inflammatory response PubMed 
    involved_in positive regulation of vascular permeability  
    involved_in positive regulation of vascular permeability  
    involved_in regulation of cAMP-mediated signaling  
    involved_in regulation of cGMP-mediated signaling  
    involved_in regulation of mitochondrion organization  
    involved_in regulation of mitochondrion organization PubMed 
    involved_in regulation of mitochondrion organization  
    acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction PubMed 
    acts_upstream_of_or_within ventricular septum development PubMed 
    Items 1 - 25 of 55
    Items 1 - 20 of 35
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in axon PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in dendrite PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in hippocampal mossy fiber  
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix PubMed 
    located_in mitochondrial matrix  
    located_in mitochondrial matrix  
    is_active_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrial outer membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    is_active_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    colocalizes_with plasma membrane  
    located_in plasma membrane  
    located_in presynaptic membrane PubMed 
    is_active_in synaptic membrane  
    located_in synaptic membrane  
    Items 1 - 20 of 35

    General protein information

    Preferred Names
    cGMP-dependent 3',5'-cyclic phosphodiesterase
    Names
    cyclic GMP-stimulated phosphodiesterase
    NP_001008548.1
    NP_001137320.1
    NP_001137321.1
    NP_001230686.1
    NP_001230687.1
    NP_001407472.1
    NP_001407473.1
    NP_001407474.1
    NP_001407475.1
    NP_001407477.1
    NP_001407478.1
    NP_001407479.1
    XP_006507586.1
    XP_006507587.1
    XP_006507589.1
    XP_006507592.1
    XP_030098167.1
    XP_036008744.1
    XP_036008745.1
    XP_036008746.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008548.5NP_001008548.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3

      See identical proteins and their annotated locations for NP_001008548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform, PDE2A3 (see, PMID:19632989) is shorter, compared to isoform 6.
      Source sequence(s)
      AC129079, AC129609
      Consensus CDS
      CCDS40043.1
      UniProtKB/TrEMBL
      Q3TYK5, Q5PR72
      Related
      ENSMUSP00000147847.2, ENSMUST00000211368.2
      Conserved Domains (2) summary
      smart00065
      Location:404553
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:650883
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. NM_001143848.3NP_001137320.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6

      See identical proteins and their annotated locations for NP_001137320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (6).
      Source sequence(s)
      AC129079, AC129609
      Consensus CDS
      CCDS52330.1
      UniProtKB/Swiss-Prot
      Q3TCR8, Q3TXZ6, Q8K2U1, Q922S4
      UniProtKB/TrEMBL
      Q3TYK5
      Related
      ENSMUSP00000131553.3, ENSMUST00000163751.10
      Conserved Domains (2) summary
      smart00065
      Location:408557
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:654884
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. NM_001143849.3NP_001137321.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2

      See identical proteins and their annotated locations for NP_001137321.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter, has a distinct 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform, PDE2A2 (see PMID:21724846) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 6.
      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      Q3TD37
      Conserved Domains (2) summary
      smart00065
      Location:397546
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:643876
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. NM_001243757.2NP_001230686.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1

      See identical proteins and their annotated locations for NP_001230686.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform, PDE2A1 (see PMID:19632989) is shorter and has a distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      F7D3W5
      Related
      ENSMUSP00000081956.9, ENSMUST00000084894.15
      Conserved Domains (2) summary
      smart00065
      Location:385534
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:631864
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    5. NM_001243758.2NP_001230687.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus, compared to isoform 6.
      Source sequence(s)
      AC129079, AC129609
      Consensus CDS
      CCDS85351.1
      UniProtKB/TrEMBL
      A0A1B0GRJ9, Q3TYK5
      Related
      ENSMUSP00000147553.2, ENSMUST00000209537.2
      Conserved Domains (2) summary
      smart00065
      Location:414563
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:660893
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    6. NM_001420543.1NP_001407472.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      F7D3W5
    7. NM_001420544.1NP_001407473.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      Q3TD37
    8. NM_001420545.1NP_001407474.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      F7D3W5
    9. NM_001420546.1NP_001407475.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      F7D3W5
    10. NM_001420548.1NP_001407477.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      Q3TYK5
    11. NM_001420549.1NP_001407478.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      Q3TYK5
    12. NM_001420550.1NP_001407479.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC129079, AC129609
      UniProtKB/TrEMBL
      Q3TD37

    RNA

    1. NR_152193.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) represents use of an alternate promoter and thus has a distinct 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC129079, AC129609
      Related
      ENSMUST00000210364.2
    2. NR_152194.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) represents use of an alternate promoter and thus has a distinct 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC129079, AC129609

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101070905..101162026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152852.1XP_036008745.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

      UniProtKB/TrEMBL
      F7D3W5
      Conserved Domains (2) summary
      smart00065
      Location:389538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:635868
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    2. XM_006507524.3XP_006507587.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2

      UniProtKB/TrEMBL
      Q3TYK5
      Conserved Domains (2) summary
      smart00065
      Location:418567
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:664897
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    3. XM_006507526.3XP_006507589.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

      See identical proteins and their annotated locations for XP_006507589.1

      UniProtKB/TrEMBL
      F7D3W5
      Conserved Domains (2) summary
      smart00065
      Location:389538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:635868
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    4. XM_036152853.1XP_036008746.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X4

      UniProtKB/TrEMBL
      Q3TYK5
      Conserved Domains (2) summary
      smart00065
      Location:386535
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:632865
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    5. XM_036152851.1XP_036008744.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X3

      UniProtKB/TrEMBL
      F7D3W5
      Conserved Domains (2) summary
      smart00065
      Location:389538
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:635868
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    6. XM_030242307.2XP_030098167.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X5

      UniProtKB/TrEMBL
      F7D3W5
      Conserved Domains (2) summary
      smart00065
      Location:385534
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:631864
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    7. XM_006507529.3XP_006507592.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X6

      See identical proteins and their annotated locations for XP_006507592.1

      UniProtKB/TrEMBL
      Q3TYK5
      Conserved Domains (2) summary
      smart00065
      Location:268417
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:514747
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    8. XM_006507523.3XP_006507586.1  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1

      UniProtKB/TrEMBL
      Q3TYK5
      Conserved Domains (2) summary
      smart00065
      Location:422571
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:668901
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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