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    LSM7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [ Homo sapiens (human) ]

    Gene ID: 51690, updated on 10-Dec-2024

    Summary

    Official Symbol
    LSM7provided by HGNC
    Official Full Name
    LSM7 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC
    Primary source
    HGNC:HGNC:20470
    See related
    Ensembl:ENSG00000130332 MIM:607287; AllianceGenome:HGNC:20470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YNL147W
    Summary
    Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
    Expression
    Ubiquitous expression in colon (RPKM 29.6), bone marrow (RPKM 20.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See LSM7 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2321521..2328586, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2295189..2302259, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2321520..2328585, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2275050-2275984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13675 Neighboring gene PEAK family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9784 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene uncharacterized LOC101928572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:2328300-2328954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13683 Neighboring gene signal peptide peptidase like 2B Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2358582-2358793 Neighboring gene transmembrane serine protease 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2376438-2376950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13684 Neighboring gene uncharacterized LOC124904612

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to RNA binding  
    enables U6 snRNA binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex  
    part_of Lsm2-8 complex PubMed 
    part_of U12-type spliceosomal complex  
    part_of U2-type precatalytic spliceosome PubMed 
    part_of U2-type prespliceosome  
    part_of U4/U6 x U5 tri-snRNP complex PubMed 
    part_of U4/U6 x U5 tri-snRNP complex PubMed 
    part_of U6 snRNP  
    part_of catalytic step 2 spliceosome  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of spliceosomal tri-snRNP complex  

    General protein information

    Preferred Names
    U6 snRNA-associated Sm-like protein LSm7
    Names
    LSM7 U6 small nuclear RNA and mRNA degradation associated
    LSM7 homolog, U6 small nuclear RNA associated

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016199.3 → NP_057283.1  U6 snRNA-associated Sm-like protein LSm7

      See identical proteins and their annotated locations for NP_057283.1

      Status: VALIDATED

      Source sequence(s)
      AF182293, BC018621, BI553911
      Consensus CDS
      CCDS45907.1
      UniProtKB/Swiss-Prot
      Q9UK45
      Related
      ENSP00000252622.8, ENST00000252622.15
      Conserved Domains (1) summary
      cd01729
      Location:9 → 97
      LSm7; Like-Sm protein 7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      2321521..2328586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      2295189..2302259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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