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    Morc4 microrchidia 4 [ Mus musculus (house mouse) ]

    Gene ID: 75746, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Morc4provided by MGI
    Official Full Name
    microrchidia 4provided by MGI
    Primary source
    MGI:MGI:1922996
    See related
    Ensembl:ENSMUSG00000031434 AllianceGenome:MGI:1922996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zcwcc2; 1600017G11Rik; 5630401M14Rik
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be active in nucleoplasm. Is expressed in genitourinary system. Orthologous to human MORC4 (MORC family CW-type zinc finger 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 39.1), liver E18 (RPKM 16.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Morc4 in Genome Data Viewer
    Location:
    X F1; X 61.35 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (138722384..138772440, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139821635..139871692, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47999 Neighboring gene ripply transcriptional repressor 1 Neighboring gene claudin 2 Neighboring gene predicted gene, 52431 Neighboring gene NMD3 homolog pseudogene Neighboring gene RNA binding motif protein 41 Neighboring gene STARR-seq mESC enhancer starr_48000 Neighboring gene nucleoporin 62 C-terminal like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107438

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MORC family CW-type zinc finger protein 4
    Names
    zinc finger CW-type coiled-coil domain protein 2
    zinc finger, CW-type with coiled-coil domain 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193309.1 → NP_001180238.1  MORC family CW-type zinc finger protein 4 isoform A

      See identical proteins and their annotated locations for NP_001180238.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) encodes the longer isoform (A).
      Source sequence(s)
      AL672243
      Consensus CDS
      CCDS57777.1
      UniProtKB/Swiss-Prot
      A2RTG5, Q4KMM6, Q8BMD7, Q8BX95, Q9CS96
      UniProtKB/TrEMBL
      A2RSL2
      Related
      ENSMUSP00000084663.6, ENSMUST00000087401.12
      Conserved Domains (2) summary
      pfam07496
      Location:422 → 466
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:50 → 141
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    2. NM_029413.4 → NP_083689.2  MORC family CW-type zinc finger protein 4 isoform B

      See identical proteins and their annotated locations for NP_083689.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform B) has a distinct C-terminus and is shorter than isoform A.
      Source sequence(s)
      AK032807, AL672243, BC132497
      Consensus CDS
      CCDS53203.1
      UniProtKB/TrEMBL
      A2RSL2
      Related
      ENSMUSP00000033811.8, ENSMUST00000033811.14
      Conserved Domains (2) summary
      pfam07496
      Location:422 → 466
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:50 → 141
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      138722384..138772440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528618.4 → XP_006528681.1  MORC family CW-type zinc finger protein 4 isoform X1

      UniProtKB/TrEMBL
      A2RSL2
      Conserved Domains (3) summary
      pfam07496
      Location:525 → 569
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:369 → 503
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
      cl00075
      Location:142 → 259
      HATPase; Histidine kinase-like ATPase domain

    2. XM_006528619.5 → XP_006528682.1  MORC family CW-type zinc finger protein 4 isoform X2

      Conserved Domains (3) summary
      pfam07496
      Location:525 → 569
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:369 → 503
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
      cl00075
      Location:142 → 259
      HATPase; Histidine kinase-like ATPase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMD7.2 GenPept UniProtKB/Swiss-Prot:Q8BMD7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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