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    Morc1 microrchidia 1 [ Mus musculus (house mouse) ]

    Gene ID: 17450, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Morc1provided by MGI
    Official Full Name
    microrchidia 1provided by MGI
    Primary source
    MGI:MGI:1316740
    See related
    Ensembl:ENSMUSG00000022652 AllianceGenome:MGI:1316740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Morc
    Summary
    Predicted to enable zinc ion binding activity. Involved in negative regulation of gene expression and spermatogenesis. Acts upstream of or within behavioral fear response; epigenetic regulation of gene expression; and negative regulation of DNA-templated transcription initiation. Is active in male germ cell nucleus. Is expressed in esophagus; head mesenchyme; musculoskeletal system; sensory organ; and testis. Used to study melancholic depression. Orthologous to human MORC1 (MORC family CW-type zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Morc1 in Genome Data Viewer
    Location:
    16 B5; 16 30.75 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (48251600..48451268)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (48431237..48630905)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 2 Neighboring gene STARR-seq mESC enhancer starr_40947 Neighboring gene predicted gene 5485 Neighboring gene STARR-seq mESC enhancer starr_40948 Neighboring gene STARR-seq mESC enhancer starr_40950 Neighboring gene STARR-seq mESC enhancer starr_40952 Neighboring gene STARR-seq mESC enhancer starr_40956 Neighboring gene STARR-seq mESC enhancer starr_40960 Neighboring gene predicted gene, 41458 Neighboring gene T cell receptor associated transmembrane adaptor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:48788868-48789191 Neighboring gene TWIST neighbor pseudogene Neighboring gene resistin like beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes. Uneme Y, et al. Proc Natl Acad Sci U S A, 2024 Mar 26. PMID 38502704, Free PMC Article
    2. Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Watson ML, et al. Proc Natl Acad Sci U S A, 1998 Nov 24. PMID 9826705, Free PMC Article
    3. Morc1 knockout evokes a depression-like phenotype in mice. Schmidt M, et al. Behav Brain Res, 2016 Jan 1. PMID 26275923
    4. New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. Inoue N, et al. Hum Mol Genet, 1999 Jul. PMID 10369865
    5. Assignment of microrchidia (Morc) to mouse chromosome 16 by interspecific backcross linkage analysis and human chromosome 3q13 using somatic cell hybrids and in situ hybridization. Inoue N, et al. Cytogenet Cell Genet, 2000. PMID 11060461

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes.
      Title: Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes.
    2. Morc1-/- mice display increased depressive-like behavior; a promising novel mouse model for depression.
      Title: Morc1 knockout evokes a depression-like phenotype in mice.
    3. MORC1 represses transposable elements in the mouse male germline.
      Title: MORC1 represses transposable elements in the mouse male germline.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Transgenic (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epigenetic programing of male pronucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of retrotransposition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transposable element silencing by heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MORC family CW-type zinc finger protein 1
    Names
    protein microrchidia

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010816.1 → NP_034946.1  MORC family CW-type zinc finger protein 1

      See identical proteins and their annotated locations for NP_034946.1

      Status: PROVISIONAL

      Source sequence(s)
      AF084945
      Consensus CDS
      CCDS37351.1
      UniProtKB/Swiss-Prot
      Q9WVL5
      Related
      ENSMUSP00000023330.7, ENSMUST00000023330.8
      Conserved Domains (2) summary
      pfam07496
      Location:481 → 528
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:27 → 159
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      48251600..48451268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVL5.1 GenPept UniProtKB/Swiss-Prot:Q9WVL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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