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    Apc2 APC regulator of WNT signaling pathway 2 [ Mus musculus (house mouse) ]

    Gene ID: 23805, updated on 27-Dec-2024

    Summary

    Official Symbol
    Apc2provided by MGI
    Official Full Name
    APC regulator of WNT signaling pathway 2provided by MGI
    Primary source
    MGI:MGI:1346052
    See related
    Ensembl:ENSMUSG00000020135 AllianceGenome:MGI:1346052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APCL
    Summary
    Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Predicted to be located in several cellular components, including cytoskeleton; lamellipodium membrane; and midbody. Predicted to be part of beta-catenin destruction complex; catenin complex; and filamentous actin. Predicted to be active in postsynapse. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including appendicular skeleton; axial skeleton; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; complex cortical dysplasia with other brain malformations; and nicotine dependence. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 41.1), CNS E14 (RPKM 27.7) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Apc2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80131790..80154091)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80295956..80318257)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene DAZ associated protein 1 Neighboring gene predicted gene 15122 Neighboring gene STARR-positive B cell enhancer ABC_E5154 Neighboring gene ribosomal protein S15 Neighboring gene STARR-positive B cell enhancer ABC_E8347 Neighboring gene RIKEN cDNA 2310011J03 gene Neighboring gene STARR-positive B cell enhancer ABC_E5155 Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene STARR-positive B cell enhancer ABC_E366 Neighboring gene predicted gene, 51809 Neighboring gene receptor accessory protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of beta-catenin destruction complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of filamentous actin ISO
    Inferred from Sequence Orthology
    more info
     
    part_of filamentous actin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenomatous polyposis coli protein 2
    Names
    adenomatosis polyposis coli 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372237.1NP_001359166.1  adenomatous polyposis coli protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140229, AC152062
      Consensus CDS
      CCDS88053.1
      UniProtKB/Swiss-Prot
      Q9Z1K7
      UniProtKB/TrEMBL
      D3YTR0
      Related
      ENSMUSP00000100996.2, ENSMUST00000105359.8
      Conserved Domains (10) summary
      PTZ00449
      Location:20282225
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00185
      Location:636676
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:15341973
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:549582
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:13991421
      APC_r; APC repeat
      pfam05956
      Location:17862111
      APC_basic; APC basic domain
      pfam11414
      Location:148228
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:719965
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:3081
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:380453
      APC_rep; Adenomatous polyposis coli (APC) repeat
    2. NM_001372238.1NP_001359167.1  adenomatous polyposis coli protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140229, AC152062
      UniProtKB/Swiss-Prot
      Q9Z1K7
      Conserved Domains (10) summary
      PTZ00449
      Location:20292226
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00185
      Location:637677
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:15351974
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:550583
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:14001422
      APC_r; APC repeat
      pfam05956
      Location:17872112
      APC_basic; APC basic domain
      pfam11414
      Location:148229
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:720966
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:3081
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:381454
      APC_rep; Adenomatous polyposis coli (APC) repeat
    3. NM_001372239.1NP_001359168.1  adenomatous polyposis coli protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC140229, AC152062
      UniProtKB/Swiss-Prot
      Q9Z1K7
      Conserved Domains (10) summary
      PTZ00449
      Location:20042201
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00185
      Location:612652
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:15101949
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:525558
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:13751397
      APC_r; APC repeat
      pfam05956
      Location:17622087
      APC_basic; APC basic domain
      pfam11414
      Location:124204
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:695941
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:657
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:356429
      APC_rep; Adenomatous polyposis coli (APC) repeat
    4. NM_001372240.1NP_001359169.1  adenomatous polyposis coli protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC140229, AC152062
      UniProtKB/Swiss-Prot
      Q9Z1K7
      Conserved Domains (10) summary
      PTZ00449
      Location:20422239
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00185
      Location:650690
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:15481987
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:563596
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:14131435
      APC_r; APC repeat
      pfam05956
      Location:18002125
      APC_basic; APC basic domain
      pfam11414
      Location:161242
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:733979
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:4394
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:394467
      APC_rep; Adenomatous polyposis coli (APC) repeat
    5. NM_001372241.1NP_001359170.1  adenomatous polyposis coli protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140229, AC152062
      UniProtKB/Swiss-Prot
      Q9Z1K7
      Conserved Domains (10) summary
      PTZ00449
      Location:20412238
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00185
      Location:649689
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:15471986
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:562595
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:14121434
      APC_r; APC repeat
      pfam05956
      Location:17992124
      APC_basic; APC basic domain
      pfam11414
      Location:161241
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:732978
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:4394
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:393466
      APC_rep; Adenomatous polyposis coli (APC) repeat
    6. NM_011789.2NP_035919.2  adenomatous polyposis coli protein 2 isoform 5

      See identical proteins and their annotated locations for NP_035919.2

      Status: VALIDATED

      Source sequence(s)
      AC140229, AC152062
      Consensus CDS
      CCDS24016.1
      UniProtKB/Swiss-Prot
      Q9Z1K7
      UniProtKB/TrEMBL
      G5E832
      Related
      ENSMUSP00000020349.7, ENSMUST00000020349.7
      Conserved Domains (8) summary
      cd00020
      Location:569687
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:13701394
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:15951613
      SAMP; SAMP Motif
      pfam05956
      Location:17572082
      APC_basic; APC basic domain
      pfam11414
      Location:124204
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:690936
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:657
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:520553
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80131790..80154091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513646.5XP_006513709.1  adenomatous polyposis coli protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Z1K7
      Conserved Domains (10) summary
      PTZ00449
      Location:20052202
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00185
      Location:613653
      ARM; Armadillo/beta-catenin-like repeats
      PHA03247
      Location:15111950
      PHA03247; large tegument protein UL36; Provisional
      sd00043
      Location:526559
      ARM; armadillo repeat [structural motif]
      pfam05923
      Location:13761398
      APC_r; APC repeat
      pfam05956
      Location:17632088
      APC_basic; APC basic domain
      pfam11414
      Location:124205
      Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
      pfam16629
      Location:696942
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16689
      Location:657
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      pfam18797
      Location:357430
      APC_rep; Adenomatous polyposis coli (APC) repeat