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    Ttc6 tetratricopeptide repeat domain 6 [ Mus musculus (house mouse) ]

    Gene ID: 70846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc6provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 6provided by MGI
    Primary source
    MGI:MGI:2684915
    See related
    Ensembl:ENSMUSG00000046782 AllianceGenome:MGI:2684915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm69; Gm9813; EG639426; 4921506M07Rik
    Summary
    Is expressed in several structures, including floor plate; future midbrain; midbrain roof plate; notochord; and trachea. Orthologous to human TTC6 (tetratricopeptide repeat domain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 5.1), bladder adult (RPKM 3.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ttc6 in Genome Data Viewer
    Location:
    12 C1; 12 24.7 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (57593490..57784697)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (57546704..57737911)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32225 Neighboring gene predicted gene, 20016 Neighboring gene TAR DNA-binding protein 43 pseudogene Neighboring gene RIKEN cDNA 4921518K17 gene Neighboring gene forkhead box A1 Neighboring gene predicted gene, 30518 Neighboring gene ribosomal protein L26, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32227 Neighboring gene cDNA sequence BC042761 Neighboring gene STARR-seq mESC enhancer starr_32229 Neighboring gene predicted gene, 46329 Neighboring gene STARR-seq mESC enhancer starr_32231 Neighboring gene somatostatin receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm. Wang Z, et al. Cells, 2023 Aug 18. PMID 37626901, Free PMC Article
    2. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm.
      Title: TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Clone Names

    • MGC118322

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312644.1 → NP_001299573.1  tetratricopeptide repeat protein 6

      Status: VALIDATED

      Source sequence(s)
      AC123067, AC123943, AI447953, AK014828, AV271916, BB616183, DV662015
      Consensus CDS
      CCDS83963.1
      UniProtKB/TrEMBL
      G3UYY4
      Conserved Domains (4) summary
      TIGR02521
      Location:1680 → 1852
      type_IV_pilW; type IV pilus biogenesis/stability protein PilW
      PTZ00436
      Location:13 → 178
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      TIGR02917
      Location:896 → 1760
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1341 → 1369
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      57593490..57784697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315184.2 → XP_017170673.1  tetratricopeptide repeat protein 6 isoform X1

      UniProtKB/TrEMBL
      G3UYY4
      Related
      ENSMUSP00000134273.2, ENSMUST00000172939.8
      Conserved Domains (4) summary
      TIGR02521
      Location:1680 → 1852
      type_IV_pilW; type IV pilus biogenesis/stability protein PilW
      PTZ00436
      Location:13 → 178
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      TIGR02917
      Location:896 → 1760
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1341 → 1369
      TPR; TPR repeat [structural motif]

    2. XM_017315185.2 → XP_017170674.1  tetratricopeptide repeat protein 6 isoform X2

      Conserved Domains (4) summary
      TIGR02521
      Location:1630 → 1802
      type_IV_pilW; type IV pilus biogenesis/stability protein PilW
      PTZ00436
      Location:13 → 178
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      TIGR02917
      Location:896 → 1710
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1635 → 1663
      TPR; TPR repeat [structural motif]

    3. XM_017315187.2 → XP_017170676.1  tetratricopeptide repeat protein 6 isoform X4

      Conserved Domains (4) summary
      TIGR02521
      Location:1487 → 1659
      type_IV_pilW; type IV pilus biogenesis/stability protein PilW
      PTZ00436
      Location:13 → 178
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      TIGR02917
      Location:895 → 1567
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1148 → 1176
      TPR; TPR repeat [structural motif]

    4. XM_017315186.2 → XP_017170675.1  tetratricopeptide repeat protein 6 isoform X3

      Conserved Domains (3) summary
      PTZ00436
      Location:13 → 178
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      TIGR02917
      Location:896 → 1745
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1341 → 1369
      TPR; TPR repeat [structural motif]

    5. XM_017315188.3 → XP_017170677.1  tetratricopeptide repeat protein 6 isoform X5

      Conserved Domains (4) summary
      PTZ00436
      Location:13 → 178
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      TIGR02917
      Location:896 → 1480
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1341 → 1369
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1477 → 1539
      TPR_12; Tetratricopeptide repeat

    6. XM_017315191.2 → XP_017170680.1  tetratricopeptide repeat protein 6 isoform X8

      Conserved Domains (4) summary
      PTZ00436
      Location:13 → 178
      PTZ00436; 60S ribosomal protein L19-like protein; Provisional
      COG0457
      Location:884 → 1113
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR02917
      Location:1024 → 1235
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1023 → 1051
      TPR; TPR repeat [structural motif]

    7. XM_017315193.2 → XP_017170682.1  tetratricopeptide repeat protein 6 isoform X10

      Conserved Domains (3) summary
      COG0457
      Location:865 → 958
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:887 → 918
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:889 → 916
      TPR_1; Tetratricopeptide repeat

    8. XM_017315192.2 → XP_017170681.1  tetratricopeptide repeat protein 6 isoform X9

      Conserved Domains (2) summary
      COG0457
      Location:865 → 1016
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:889 → 917
      TPR; TPR repeat [structural motif]

    9. XM_030246911.2 → XP_030102771.1  tetratricopeptide repeat protein 6 isoform X7

      Conserved Domains (3) summary
      COG4783
      Location:1231 → 1390
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
      TIGR02917
      Location:436 → 1300
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:881 → 909
      TPR; TPR repeat [structural motif]

    10. XM_017315189.3 → XP_017170678.1  tetratricopeptide repeat protein 6 isoform X6

      Conserved Domains (3) summary
      COG4783
      Location:1397 → 1556
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
      TIGR02917
      Location:602 → 1466
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:1047 → 1075
      TPR; TPR repeat [structural motif]

    11. XM_030246912.2 → XP_030102772.1  tetratricopeptide repeat protein 6 isoform X12

      Conserved Domains (4) summary
      COG0457
      Location:1 → 213
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      TIGR00990
      Location:110 → 323
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      TIGR02917
      Location:253 → 646
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:480 → 508
      TPR; TPR repeat [structural motif]

    12. XM_017315194.2 → XP_017170683.1  tetratricopeptide repeat protein 6 isoform X11

      Conserved Domains (3) summary
      COG4783
      Location:693 → 852
      YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]
      TIGR02917
      Location:23 → 762
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:687 → 715
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_001780477.2 RNA Sequence

    2. XR_001780479.2 RNA Sequence

    3. XR_001780482.2 RNA Sequence

    4. XR_001780478.2 RNA Sequence

    5. XR_001780481.2 RNA Sequence

    6. XR_001780480.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037743.1: Suppressed sequence

      Description
      NM_001037743.1: This RefSeq was removed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version

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