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    Csnk2a2 casein kinase 2, alpha prime polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 13000, updated on 9-Dec-2024

    Summary

    Official Symbol
    Csnk2a2provided by MGI
    Official Full Name
    casein kinase 2, alpha prime polypeptideprovided by MGI
    Primary source
    MGI:MGI:88547
    See related
    Ensembl:ENSMUSG00000046707 AllianceGenome:MGI:88547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK2; 1110035J23Rik
    Summary
    Enables protein serine/threonine kinase activity. Acts upstream of or within protein phosphorylation; regulation of cell cycle; and spermatogenesis. Predicted to be located in acrosomal vesicle and chromatin. Predicted to be part of PcG protein complex and protein kinase CK2 complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study male infertility. Orthologous to human CSNK2A2 (casein kinase 2 alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.5), CNS E11.5 (RPKM 7.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Csnk2a2 in Genome Data Viewer
    Location:
    8 C5- D1; 8 47.12 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96172724..96215505, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95446096..95488868, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 15 Neighboring gene VISTA enhancer mm71 Neighboring gene STARR-positive B cell enhancer ABC_E245 Neighboring gene cilia and flagella associated protein 20 Neighboring gene STARR-seq mESC enhancer starr_22388 Neighboring gene RIKEN cDNA 4933406B17 gene Neighboring gene STARR-seq mESC enhancer starr_22390 Neighboring gene coiled-coil domain containing 113

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in Wnt signaling pathway  
    involved_in apoptotic process  
    involved_in chromatin remodeling  
    involved_in double-strand break repair  
    involved_in double-strand break repair  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    involved_in regulation of chromosome separation  
    involved_in regulation of chromosome separation  
    involved_in regulation of chromosome separation  
    acts_upstream_of_or_within spermatogenesis PubMed 
    Component Evidence Code Pubs
    part_of PcG protein complex  
    part_of PcG protein complex  
    located_in acrosomal vesicle  
    located_in chromatin  
    is_active_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    located_in nucleus  
    part_of protein kinase CK2 complex  
    part_of protein kinase CK2 complex PubMed 

    General protein information

    Preferred Names
    casein kinase II subunit alpha'
    Names
    CK II alpha'
    casein kinase II, alpha 2, polypeptide
    NP_034104.1
    XP_006530704.1
    XP_006530705.1
    XP_006530706.1
    XP_030099139.1
    XP_036009637.1
    XP_036009638.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009974.3NP_034104.1  casein kinase II subunit alpha'

      See identical proteins and their annotated locations for NP_034104.1

      Status: VALIDATED

      Source sequence(s)
      AC165414, AK002927, AK030035, BM963966, CB056745
      Consensus CDS
      CCDS22562.1
      UniProtKB/Swiss-Prot
      O54833
      UniProtKB/TrEMBL
      Q545V8, Q8BPF9
      Related
      ENSMUSP00000055919.8, ENSMUST00000056919.9
      Conserved Domains (1) summary
      cd14132
      Location:22326
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96172724..96215505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530641.5XP_006530704.1  casein kinase II subunit alpha' isoform X1

      UniProtKB/TrEMBL
      Q8BPF9
      Conserved Domains (1) summary
      cd14132
      Location:22275
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    2. XM_006530643.4XP_006530706.1  casein kinase II subunit alpha' isoform X2

      See identical proteins and their annotated locations for XP_006530706.1

      UniProtKB/TrEMBL
      A0A1D5RM74
      Conserved Domains (1) summary
      cd14132
      Location:1189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    3. XM_006530642.2XP_006530705.1  casein kinase II subunit alpha' isoform X2

      See identical proteins and their annotated locations for XP_006530705.1

      UniProtKB/TrEMBL
      A0A1D5RM74
      Conserved Domains (1) summary
      cd14132
      Location:1189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    4. XM_030243279.2XP_030099139.1  casein kinase II subunit alpha' isoform X2

      UniProtKB/TrEMBL
      A0A1D5RM74
      Related
      ENSMUSP00000148660.2, ENSMUST00000212616.2
      Conserved Domains (1) summary
      cd14132
      Location:1189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    5. XM_036153744.1XP_036009637.1  casein kinase II subunit alpha' isoform X2

      UniProtKB/TrEMBL
      A0A1D5RM74
      Conserved Domains (1) summary
      cd14132
      Location:1189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    6. XM_036153745.1XP_036009638.1  casein kinase II subunit alpha' isoform X2

      UniProtKB/TrEMBL
      A0A1D5RM74
      Conserved Domains (1) summary
      cd14132
      Location:1189
      STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
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