PSMB7 proteasome 20S subunit beta 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PSMB7provided by HGNC
Official Full Name: proteasome 20S subunit beta 7provided by HGNC
Primary source: HGNC:HGNC:9544
See related: Ensembl:ENSG00000136930 MIM:604030; AllianceGenome:HGNC:9544
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Jul 2012]
Expression: Ubiquitous expression in testis (RPKM 70.4), adrenal (RPKM 65.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q33.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (124353465..124415442, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (136551512..136613496, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (127115744..127177721, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studied the associations of Protein Z (PROZ G79A) and Endothelin-1 (EDN1 G5665T) polymorphisms with the clinical features of sickle cell disease (SCD) in a cohort of Egyptian children with SCD.
Title: Protein Z and Endothelin-1 genetic polymorphisms in pediatric Egyptian sickle cell disease patients.
reduced protein levels in patients with rheumatoid arthritis in association with disease progression
Title: Decreased proteinZ levels in patients with rheumatoid arthritis: links with inflammation.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
high PSMB7 expression is associated with anthracycline resistance in breast cancer.
Title: PSMB7 is associated with anthracycline resistance and is a prognostic biomarker in breast cancer.
we have identified and characterized a new phosphorylated isoform of the human 20S proteasome b7 subunit and showed its differential expression in tumor vs. normal cell lines
Title: Characterization and differential expression of a newly identified phosphorylated isoform of the human 20S proteasome beta7 subunit in tumor vs. normal cell lines.
Low protein Z levels but not protein Z gene G79A polymorphism are a risk factor for ischemic stroke.
Title: Low protein Z levels but not the protein Z gene G79A polymorphism are a risk factor for ischemic stroke.
ZPI functions like other serpins to regulate the activity of FXa but in a manner uniquely dependent on protein Z, procoagulant membranes, and pH
Title: Kinetic characterization of the protein Z-dependent protease inhibitor reaction with blood coagulation factor Xa.
A previously unreported sporadic missense mutation within exon 8 is described in a patient with very low protein Z levels.
Title: An unreported mutation within protein Z gene is associated with very low protein levels in women with fetal loss.
PSB7, PRDX1, and SRP9 up-regulation as candidate biomarkers of colon cancer is discovered
Title: Proteomic expression analysis of surgical human colorectal cancer tissues: up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome	PubMed
	tat	Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation	PubMed
	tat	HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex	PubMed
	tat	HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function	PubMed
Vif	vif	HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication	PubMed
integrase	gag-pol	Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH119892 (e-PCR)
- UniSTS:133636

WI-15624 (e-PCR)
- UniSTS:70669

Cda0vc07 (e-PCR)
- UniSTS:1852

D9S1698 (e-PCR)
- UniSTS:2665

RH70504 (e-PCR)
- UniSTS:59757

MARC_8227-8228:996688432:1 (e-PCR)
- UniSTS:269936

RH11599 (e-PCR)
- UniSTS:61308

SHGC-154753 (e-PCR)
- UniSTS:184960

RH12239 (e-PCR)
- UniSTS:63110

SGC33089 (e-PCR)
- UniSTS:78220

A003A40 (e-PCR)
- UniSTS:45475

D9S1989 (e-PCR)
- UniSTS:60595

D9S997E (e-PCR)
- UniSTS:151244

RH77983 (e-PCR)
- UniSTS:226

RH11482 (e-PCR)
- UniSTS:58088

G20648 (e-PCR)
- UniSTS:68859

A006A17 (e-PCR)
- UniSTS:68860

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in ficolin-1-rich granule lumen	TAS Traceable Author Statement more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	NAS Non-traceable Author Statement more info	PubMed
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	ISS Inferred from Sequence or Structural Similarity more info
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: proteasome subunit beta type-7

Names: beta-2; epididymis secretory sperm binding protein; macropain chain Z; multicatalytic endopeptidase complex chain Z; proteasome (prosome, macropain) subunit, beta type, 7; proteasome catalytic subunit 2; proteasome subunit Z; proteasome subunit alpha; proteasome subunit beta 7; proteasome subunit beta-2; proteasome subunit beta2; protein serine kinase c17

NP_002790.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002799.4 → NP_002790.1 proteasome subunit beta type-7 precursor

See identical proteins and their annotated locations for NP_002790.1

Status: REVIEWED

Source sequence(s)

GU727627

Consensus CDS

CCDS6855.1

UniProtKB/Swiss-Prot

B4E0P1, Q5TBG6, Q96AG8, Q99436, Q9BWA7

UniProtKB/TrEMBL

B2RAQ9, E9KL30, Q86U62

Related

ENSP00000259457.3, ENST00000259457.8

Conserved Domains (2) summary

cd03763
Location:44 → 232

proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

pfam12465
Location:236 → 271

Pr_beta_C; Proteasome beta subunits C terminal