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    unc-89 Muscle M-line assembly protein unc-89 [ Caenorhabditis elegans ]

    Gene ID: 171990, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-89
    Official Full Name
    Muscle M-line assembly protein unc-89
    Primary source
    WormBase:WBGene00006820
    Locus tag
    CELE_C09D1.1
    See related
    AllianceGenome:WB:WBGene00006820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables MATH domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including myofibril assembly; nematode pharyngeal gland morphogenesis; and regulation of striated muscle contraction. Located in M band. Is expressed in several structures, including alimentary muscle; body wall musculature; pharynx; tail; and vulval muscle. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Orthologous to human SPEG (striated muscle enriched protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-89 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    51
    Sequence:
    Chromosome: I; NC_003279.8 (4035702..4090885)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CRAL-TRIO domain-containing protein;DH domain-containing protein;Rho guanine nucleotide exchange factor 26;Triple functional domain protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene ncRNA Neighboring gene DEgenerin Like Neighboring gene DEgenerin Like

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables MATH domain binding PubMed 
    enables guanyl-nucleotide exchange factor activity PubMed 
    enables guanyl-nucleotide exchange factor activity  
    NOT enables inositol 1,4,5 trisphosphate binding PubMed 
    enables phosphatase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity  
    enables small GTPase binding PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in muscle structure development  
    involved_in myosin filament assembly PubMed 
    involved_in nematode pharyngeal gland morphogenesis PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of locomotion PubMed 
    involved_in positive regulation of protein localization to endoplasmic reticulum PubMed 
    involved_in positive regulation of sarcomere organization PubMed 
    involved_in positive regulation of striated muscle contraction PubMed 
    involved_in protein localization PubMed 
    involved_in protein phosphorylation  
    NOT involved_in regulation of protein localization to endoplasmic reticulum PubMed 
    involved_in regulation of skeletal muscle contraction by calcium ion signaling PubMed 
    involved_in sarcomere organization PubMed 
    involved_in skeletal muscle myosin thick filament assembly PubMed 
    involved_in striated muscle myosin thick filament assembly PubMed 
    Component Evidence Code Pubs
    located_in A band PubMed 
    located_in M band PubMed 
    located_in M band  
    located_in cytoplasm  
    located_in organelle  

    General protein information

    Preferred Names
    Muscle M-line assembly protein unc-89
    NP_001020984.1
    • Confirmed by transcript evidence
    NP_001020985.1
    • Confirmed by transcript evidence
    NP_001020988.1
    • Confirmed by transcript evidence
    NP_001020989.1
    • Confirmed by transcript evidence
    NP_001293453.1
    • Confirmed by transcript evidence
    NP_001293454.1
    • Confirmed by transcript evidence
    NP_001343617.1
    • Partially confirmed by transcript evidence
    NP_001343711.1
    • Partially confirmed by transcript evidence
    NP_001343712.1
    • Partially confirmed by transcript evidence
    NP_001343713.1
    • Partially confirmed by transcript evidence
    NP_001343714.1
    • Confirmed by transcript evidence
    NP_001343715.1
    • Confirmed by transcript evidence
    NP_001343716.1
    • Confirmed by transcript evidence
    NP_001343717.1
    • Confirmed by transcript evidence
    NP_001343718.1
    • Confirmed by transcript evidence
    NP_001343719.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4035702..4090885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025813.2 → NP_001020984.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01761
      Conserved Domains (13) summary
      cd00096
      Location:5614 → 5681
      Ig; Immunoglobulin domain
      cd04972
      Location:2075 → 2164
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00408
      Location:5501 → 5567
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:6275 → 6358
      FN3; Fibronectin type 3 domain
      smart00410
      Location:6413 → 6501
      IG_like; Immunoglobulin like
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      TIGR04420
      Location:1625 → 1800
      Sec_Non_Glob; Sec region non-globular protein
      pfam05177
      Location:1576 → 1678
      RCSD; RCSD region
      pfam16496
      Location:1425 → 1499
      SWIRM-assoc_2; SWIRM-associated domain at the N-terminal
      cl11960
      Location:5094 → 5161
      Ig; Immunoglobulin domain
      cl17036
      Location:65 → 124
      SH3; Src Homology 3 domain superfamily
    2. NM_001025814.4 → NP_001020985.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020985.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01761, Q17362, Q5W614, Q5W615, Q5W616, Q5W617, Q646H5, Q64EQ8, Q7Z119, Q7Z120
      Conserved Domains (15) summary
      cd00096
      Location:5614 → 5681
      Ig; Immunoglobulin domain
      cd04972
      Location:2075 → 2164
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00408
      Location:5501 → 5567
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:6275 → 6358
      FN3; Fibronectin type 3 domain
      smart00220
      Location:6640 → 6878
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00410
      Location:6413 → 6501
      IG_like; Immunoglobulin like
      cd00063
      Location:7621 → 7716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14109
      Location:6620 → 6878
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:7781 → 8035
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      pfam05177
      Location:1576 → 1678
      RCSD; RCSD region
      cl11960
      Location:5094 → 5161
      Ig; Immunoglobulin domain
      cl17036
      Location:65 → 124
      SH3; Src Homology 3 domain superfamily
    3. NM_001356807.3 → NP_001343717.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C3B7
      Conserved Domains (11) summary
      cd04972
      Location:2075 → 2164
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:5555 → 5638
      FN3; Fibronectin type 3 domain
      cd00063
      Location:6901 → 6996
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14112
      Location:7061 → 7315
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl17036
      Location:65 → 124
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:5900 → 6158
      PKc_like; Protein Kinases, catalytic domain
      cl26511
      Location:1345 → 1992
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:4557 → 4647
      I-set; Immunoglobulin I-set domain
    4. NM_001356808.3 → NP_001343716.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2W9
      Conserved Domains (11) summary
      cd04972
      Location:2075 → 2164
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:5702 → 5785
      FN3; Fibronectin type 3 domain
      cd00063
      Location:7048 → 7143
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14112
      Location:7208 → 7462
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl17036
      Location:65 → 124
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:6047 → 6305
      PKc_like; Protein Kinases, catalytic domain
      cl26511
      Location:1304 → 1992
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:946 → 1034
      I-set; Immunoglobulin I-set domain
    5. NM_001356809.3 → NP_001343714.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2S8
      Conserved Domains (11) summary
      cd04972
      Location:2053 → 2142
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:6253 → 6336
      FN3; Fibronectin type 3 domain
      cd00063
      Location:7599 → 7694
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14109
      Location:6598 → 6856
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:7759 → 8013
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl17036
      Location:65 → 124
      SH3; Src Homology 3 domain superfamily
      cl26511
      Location:1323 → 1970
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:946 → 1034
      I-set; Immunoglobulin I-set domain
    6. NM_001025818.3 → NP_001020989.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01761
      Conserved Domains (14) summary
      cd00096
      Location:4974 → 5041
      Ig; Immunoglobulin domain
      cd04972
      Location:1435 → 1524
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00408
      Location:4861 → 4927
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:65 → 124
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:5635 → 5718
      FN3; Fibronectin type 3 domain
      smart00220
      Location:6000 → 6238
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:5773 → 5861
      IG; Immunoglobulin
      cd00063
      Location:6981 → 7076
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14112
      Location:7141 → 7395
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl11960
      Location:4454 → 4521
      Ig; Immunoglobulin domain
      cl21453
      Location:5980 → 6238
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001356810.3 → NP_001343718.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C365
      Conserved Domains (8) summary
      cd04972
      Location:2075 → 2164
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:5555 → 5638
      FN3; Fibronectin type 3 domain
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cl17036
      Location:65 → 124
      SH3; Src Homology 3 domain superfamily
      cl26511
      Location:1304 → 1992
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:2269 → 2360
      I-set; Immunoglobulin I-set domain
    8. NM_001356811.3 → NP_001343715.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C330
      Conserved Domains (8) summary
      cd04972
      Location:2053 → 2142
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:6253 → 6336
      FN3; Fibronectin type 3 domain
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cl17036
      Location:65 → 124
      SH3; Src Homology 3 domain superfamily
      cl26511
      Location:1282 → 1970
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:2247 → 2338
      I-set; Immunoglobulin I-set domain
    9. NM_001025817.4 → NP_001020988.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020988.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01761
      Conserved Domains (10) summary
      cd00096
      Location:4974 → 5041
      Ig; Immunoglobulin domain
      cd04972
      Location:1435 → 1524
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00408
      Location:4861 → 4927
      IGc2; Immunoglobulin C-2 Type
      cd12025
      Location:65 → 124
      SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins
      smart00060
      Location:5635 → 5718
      FN3; Fibronectin type 3 domain
      smart00409
      Location:5773 → 5861
      IG; Immunoglobulin
      cd00160
      Location:153 → 328
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:648 → 737
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:341 → 455
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cl11960
      Location:4454 → 4521
      Ig; Immunoglobulin domain
    10. NM_001356812.3 → NP_001343617.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (8) summary
      cd04972
      Location:1602 → 1691
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:5802 → 5885
      FN3; Fibronectin type 3 domain
      cd00063
      Location:7148 → 7243
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:175 → 264
      I-set; Immunoglobulin I-set domain
      cd14109
      Location:6147 → 6405
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:7308 → 7562
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl26511
      Location:872 → 1519
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:473 → 561
      I-set; Immunoglobulin I-set domain
    11. NM_001356813.3 → NP_001343719.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2G8
      Conserved Domains (8) summary
      cd04972
      Location:1602 → 1691
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:5082 → 5165
      FN3; Fibronectin type 3 domain
      cd00063
      Location:6428 → 6523
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:175 → 264
      I-set; Immunoglobulin I-set domain
      cd14109
      Location:5427 → 5685
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:6588 → 6842
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl26511
      Location:860 → 1519
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:473 → 561
      I-set; Immunoglobulin I-set domain
    12. NM_001356814.3 → NP_001343711.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2V3
      Conserved Domains (8) summary
      cd04972
      Location:1602 → 1691
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:5229 → 5312
      FN3; Fibronectin type 3 domain
      cd00063
      Location:6575 → 6670
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:175 → 264
      I-set; Immunoglobulin I-set domain
      cd14109
      Location:5574 → 5832
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:6735 → 6989
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl26511
      Location:831 → 1519
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:473 → 561
      I-set; Immunoglobulin I-set domain
    13. NM_001356815.3 → NP_001343712.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C2V5
      Conserved Domains (8) summary
      cd04972
      Location:1580 → 1669
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:5780 → 5863
      FN3; Fibronectin type 3 domain
      cd00063
      Location:7126 → 7221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:175 → 264
      I-set; Immunoglobulin I-set domain
      cd14109
      Location:6125 → 6383
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:7286 → 7540
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl26511
      Location:850 → 1497
      Neuromodulin_N; Gap junction protein N-terminal region
      cl28434
      Location:473 → 561
      I-set; Immunoglobulin I-set domain
    14. NM_001356816.3 → NP_001343713.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2C9C332
      Conserved Domains (7) summary
      cd04972
      Location:962 → 1051
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      smart00060
      Location:5162 → 5245
      FN3; Fibronectin type 3 domain
      cd00063
      Location:6508 → 6603
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:175 → 264
      I-set; Immunoglobulin I-set domain
      cd14112
      Location:6668 → 6922
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl21453
      Location:5507 → 5765
      PKc_like; Protein Kinases, catalytic domain
      cl28434
      Location:869 → 955
      I-set; Immunoglobulin I-set domain
    15. NM_001306525.3 → NP_001293454.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01761
      Conserved Domains (6) summary
      smart00220
      Location:1108 → 1350
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:936 → 1031
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:843 → 931
      I-set; Immunoglobulin I-set domain
      cd14112
      Location:1096 → 1350
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl11960
      Location:861 → 931
      Ig; Immunoglobulin domain
      cl21453
      Location:12 → 193
      PKc_like; Protein Kinases, catalytic domain
    16. NM_001306524.2 → NP_001293453.1  Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01761
      Conserved Domains (6) summary
      smart00220
      Location:1105 → 1347
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:933 → 1028
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:840 → 928
      I-set; Immunoglobulin I-set domain
      cd14112
      Location:1093 → 1347
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl11960
      Location:858 → 928
      Ig; Immunoglobulin domain
      cl21453
      Location:9 → 190
      PKc_like; Protein Kinases, catalytic domain
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