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    Pdfr Pigment-dispersing factor receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31234, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pdfrprovided by FlyBase
    Official Full Name
    Pigment-dispersing factor receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260753
    Locus tag
    Dmel_CG13758
    See related
    AllianceGenome:FB:FBgn0260753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.157; anon-WO0170980.158; BACR25B3.3; CG13758; DmeCG13758; Dmel\CG13758; EG:BACR25B3.3; gop; han; Han; Pdf R; PDF-R; Pdf-R1; PDF-R1; pdfr; pdfR; PdfR; PDFR; PDFR-1
    Summary
    Enables neuropeptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; circadian temperature homeostasis; and locomotor rhythm. Located in neuron projection; neuronal cell body; and plasma membrane. Is expressed in several structures, including adult brain; adult gnathal ganglion; adult neuromere; adult pacemaker neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in achalasia; cardiovascular system disease; diabetes mellitus (multiple); isolated growth hormone deficiency (multiple); and obesity. Orthologous to several human genes including ADCYAP1R1 (ADCYAP receptor type I); GIPR (gastric inhibitory polypeptide receptor); and GLP1R (glucagon like peptide 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Pdfr in Genome Data Viewer
    Location:
    3A4-3A6; 1-1 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2552206..2578640)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2446239..2472673)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene brother of ihog Neighboring gene zeste Neighboring gene terribly reduced optic lobes Neighboring gene mir-4955 stem loop Neighboring gene Vacuolar H[+] ATPase 36kD subunit 3 Neighboring gene Arylalkylamine N-acetyltransferase-like 7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity  
    enables G protein-coupled receptor activity  
    enables calcitonin receptor activity PubMed 
    enables neuropeptide receptor activity PubMed 
    enables neuropeptide receptor activity PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
    involved_in cell surface receptor signaling pathway  
    involved_in circadian behavior PubMed 
    involved_in circadian behavior PubMed 
    involved_in circadian rhythm PubMed 
    involved_in circadian rhythm PubMed 
    involved_in circadian sleep/wake cycle PubMed 
    involved_in circadian temperature homeostasis PubMed 
    involved_in copper ion homeostasis PubMed 
    involved_in gravitaxis PubMed 
    involved_in locomotor rhythm PubMed 
    involved_in neuropeptide signaling pathway PubMed 
    involved_in positive regulation of calcium-mediated signaling PubMed 
    involved_in regulation of circadian rhythm PubMed 
    involved_in regulation of circadian rhythm PubMed 
    involved_in regulation of circadian sleep/wake cycle PubMed 
    involved_in response to paraquat PubMed 
    Component Evidence Code Pubs
    located_in membrane  
    located_in membrane PubMed 
    located_in membrane PubMed 
    located_in membrane PubMed 
    located_in neuron projection PubMed 
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    Pigment-dispersing factor receptor
    Names
    CG13758-PA
    CG13758-PB
    CG13758-PC
    CG13758-PD
    PDF receptor
    PDF-receptor
    Pdf recep- tor
    Pdfr-PA
    Pdfr-PB
    Pdfr-PC
    Pdfr-PD
    groom of PDF
    groom-of-pdf
    pigment dispersing factor receptor
    pigment dispersing factor receptor 1
    pigment-dispersing factor receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2552206..2578640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297898.1NP_001284827.1  Pigment-dispersing factor receptor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHT0
      Conserved Domains (2) summary
      pfam02793
      Location:144203
      HRM; Hormone receptor domain
      cl21561
      Location:237494
      7tm_4; Olfactory receptor
    2. NM_001297897.1NP_001284826.1  Pigment-dispersing factor receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284826.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHT0
      Conserved Domains (2) summary
      pfam02793
      Location:144203
      HRM; Hormone receptor domain
      cl21561
      Location:237494
      7tm_4; Olfactory receptor
    3. NM_130651.3NP_570007.2  Pigment-dispersing factor receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570007.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A158RFU8, M9NET6, Q9NEF7, Q9W4Y2, X2JDL2
      UniProtKB/TrEMBL
      D5SHT0
      Conserved Domains (2) summary
      pfam02793
      Location:144203
      HRM; Hormone receptor domain
      cl21561
      Location:237494
      7tm_4; Olfactory receptor
    4. NM_001258572.1NP_001245501.1  Pigment-dispersing factor receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245501.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHT0
      Conserved Domains (2) summary
      pfam02793
      Location:213272
      HRM; Hormone receptor domain
      cl21561
      Location:306563
      7tm_4; Olfactory receptor
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