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    fzr2 fizzy-related 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37808, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fzr2provided by FlyBase
    Official Full Name
    fizzy-related 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034937
    Locus tag
    Dmel_CG16783
    See related
    AllianceGenome:FB:FBgn0034937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16783; Dmel\CG16783; FZR2
    Summary
    Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process and male meiotic nuclear division. Predicted to be part of anaphase-promoting complex. Is expressed in organism; spermatocyte; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fzr2 in Genome Data Viewer
    Location:
    60A13-60A13; 2-105 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23950647..23952096)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19838170..19839619)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene G protein alpha subunit s Neighboring gene orcokinin Neighboring gene Stomatin like 2 Neighboring gene uncharacterized protein Neighboring gene thoc5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Completion of mitosis requires neither fzr/rap nor fzr2, a male germline-specific Drosophila Cdh1 homolog. Jacobs H, et al. Curr Biol, 2002 Aug 20. PMID 12194827
    2. The Drosophila melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID. Jäger H, et al. Chromosoma, 2005 Feb. PMID 15592865
    3. The anaphase-promoting complex/cyclosome: APC/C. Acquaviva C, et al. J Cell Sci, 2006 Jun 15. PMID 16763193
    4. Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator. Pesin JA, et al. PLoS Genet, 2007 Nov. PMID 18020708, Free PMC Article
    5. The THO complex is required for nucleolar integrity in Drosophila spermatocytes. Moon S, et al. Development, 2011 Sep. PMID 21828100

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in exit from mitosis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in male meiotic nuclear division IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fizzy-related 2
    Names
    CG16783-PA
    fzr2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23950647..23952096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138010.4 → NP_611854.1  fizzy-related 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611854.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1F6
      Related
      FBpp0072055
      Conserved Domains (3) summary
      COG2319
      Location:101 → 439
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:190 → 227
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:190 → 446
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1F6 Q9W1F6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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