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    CG12061 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12061provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040031
    Locus tag
    Dmel_CG12061
    See related
    AllianceGenome:FB:FBgn0040031
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG40148; Dmel\CG12061
    Summary
    Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Predicted to be involved in calcium ion transmembrane transport and intracellular calcium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in oculocutaneous albinism type VI. Orthologous to human SLC24A5 (solute carrier family 24 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12061 in Genome Data Viewer
    Location:
    20F4-20F4; 1-66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (23036066..23047678)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) XHet NW_001848859.1 (14884..26496)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase assembly factor 7 Neighboring gene zydeco Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Junion G, et al. Genes Dev, 2007 Dec 1. PMID 18056427, Free PMC Article
    2. Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen. Brody T, et al. Mech Dev, 2002 Apr. PMID 11900973
    3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
    4. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    5. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 23039514-23040885 mobile_element_type = transposon:Tc1{}6597

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium, potassium:sodium antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12061-PD
    CG12061-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      23036066..23047678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001110997.2 → NP_001104467.2  uncharacterized protein Dmel_CG12061, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001104467.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8Y5A2
      Conserved Domains (2) summary
      TIGR00367
      Location:61 → 422
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:276 → 424
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_001015258.2 → NP_001015258.3  uncharacterized protein Dmel_CG12061, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015258.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PLW3
      Conserved Domains (2) summary
      TIGR00367
      Location:14 → 349
      TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein
      pfam01699
      Location:203 → 351
      Na_Ca_ex; Sodium/calcium exchanger protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8Y5A2 A8Y5A2
    Q7PLW3 Q7PLW3

    Gene LinkOut

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