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    Exoc4 exocyst complex component 4 [ Mus musculus (house mouse) ]

    Gene ID: 20336, updated on 13-Jan-2025

    Summary

    Official Symbol
    Exoc4provided by MGI
    Official Full Name
    exocyst complex component 4provided by MGI
    Primary source
    MGI:MGI:1096376
    See related
    Ensembl:ENSMUSG00000029763 AllianceGenome:MGI:1096376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sec8; Sec8l1
    Summary
    Enables PDZ domain binding activity. Acts upstream of or within paraxial mesoderm formation and protein transmembrane transport. Located in growth cone membrane; microvillus; and myelin sheath abaxonal region. Is expressed in several structures, including central nervous system; extraembryonic component; ganglia; and retina. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 5.5), CNS E11.5 (RPKM 5.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Exoc4 in Genome Data Viewer
    Location:
    6 A3.3; 6 14.59 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (33226025..33950914)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (33249090..33973979)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15518 Neighboring gene predicted gene, 22321 Neighboring gene STARR-seq mESC enhancer starr_15519 Neighboring gene STARR-seq mESC enhancer starr_15522 Neighboring gene STARR-seq mESC enhancer starr_15523 Neighboring gene zinc finger protein 212 pseudogene Neighboring gene heat shock protein 8 pseudogene Neighboring gene predicted gene, 38785 Neighboring gene STARR-seq mESC enhancer starr_15525 Neighboring gene STARR-seq mESC enhancer starr_15527 Neighboring gene STARR-seq mESC enhancer starr_15528 Neighboring gene STARR-seq mESC enhancer starr_15529 Neighboring gene STARR-positive B cell enhancer ABC_E10372 Neighboring gene predicted gene 13853 Neighboring gene predicted gene, 38786 Neighboring gene leucine-rich repeats and guanylate kinase domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding PubMed 
    enables PDZ domain binding  
    enables ionotropic glutamate receptor binding  
    enables protein binding PubMed 
    enables protein-containing complex binding  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport  
    involved_in Golgi to transport vesicle transport  
    involved_in chemical synaptic transmission  
    involved_in chemical synaptic transmission  
    involved_in establishment of cell polarity  
    involved_in exocytosis  
    involved_in membrane biogenesis  
    involved_in membrane fission PubMed 
    involved_in mitotic cytokinesis PubMed 
    involved_in oligodendrocyte differentiation  
    acts_upstream_of_or_within paraxial mesoderm formation PubMed 
    involved_in positive regulation of calcium-mediated signaling  
    involved_in protein targeting to membrane  
    acts_upstream_of_or_within protein transmembrane transport PubMed 
    involved_in regulation of protein transport  
    involved_in vesicle docking involved in exocytosis PubMed 
    involved_in vesicle tethering involved in exocytosis PubMed 
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    located_in Flemming body  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in cell leading edge  
    located_in centrosome  
    located_in centrosome  
    located_in cytoplasm  
    located_in dendrite  
    located_in dendritic shaft  
    located_in endosome  
    part_of exocyst  
    part_of exocyst PubMed 
    located_in growth cone  
    is_active_in growth cone membrane  
    located_in growth cone membrane PubMed 
    located_in microvillus PubMed 
    located_in myelin sheath abaxonal region PubMed 
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in neuronal cell body  
    located_in plasma membrane  
    located_in postsynaptic density  
    is_active_in postsynaptic density, intracellular component  
    part_of protein-containing complex  
    is_active_in synapse  
    located_in synapse  
    is_active_in synaptic vesicle  
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    exocyst complex component 4
    Names
    SEC8-like 1
    exocyst complex component Sec8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347089.2NP_001334018.1  exocyst complex component 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC132453, AC152961
      Consensus CDS
      CCDS85028.1
      UniProtKB/TrEMBL
      Q8C391, Q9CXE1
      Related
      ENSMUSP00000087859.5, ENSMUST00000090381.11
    2. NM_009148.4NP_033174.2  exocyst complex component 4 isoform 1

      See identical proteins and their annotated locations for NP_033174.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132453, AC141927, AC152961, AC154020, AC155915
      Consensus CDS
      CCDS19987.1
      UniProtKB/Swiss-Prot
      O35382
      UniProtKB/TrEMBL
      Q69ZD1
      Related
      ENSMUSP00000051965.9, ENSMUST00000052266.15
      Conserved Domains (1) summary
      pfam04048
      Location:57143
      Sec8_exocyst; Sec8 exocyst complex component specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      33226025..33950914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241262.1XP_011239564.1  exocyst complex component 4 isoform X1

      UniProtKB/TrEMBL
      Q8CA11
      Conserved Domains (1) summary
      pfam04048
      Location:57143
      Sec8_exocyst; Sec8 exocyst complex component specific domain
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