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    Braf Braf transforming gene [ Mus musculus (house mouse) ]

    Gene ID: 109880, updated on 28-Jan-2025

    Summary

    Official Symbol
    Brafprovided by MGI
    Official Full Name
    Braf transforming geneprovided by MGI
    Primary source
    MGI:MGI:88190
    See related
    Ensembl:ENSMUSG00000002413 AllianceGenome:MGI:88190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B-raf; Braf2; Braf-2; C230098H17; D6Ertd631e; 9930012E13Rik
    Summary
    Enables protein kinase activity. Involved in postsynaptic modulation of chemical synaptic transmission and protein phosphorylation. Acts upstream of or within several processes, including hemopoiesis; negative regulation of apoptotic process; and positive regulation of cellular component organization. Located in several cellular components, including cell body; mitochondrion; and neuron projection. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Langerhans-cell histiocytosis; cardiofaciocutaneous syndrome; melanoma (multiple); papillary thyroid carcinoma; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 6.7), bladder adult (RPKM 6.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Braf in Genome Data Viewer
    Location:
    6 B1; 6 18.43 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39580171..39702592, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39603231..39725658, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene aarF domain containing kinase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene predicted gene, 34389 Neighboring gene ferritin heavy chain, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_15669 Neighboring gene STARR-seq mESC enhancer starr_15670 Neighboring gene STARR-seq mESC enhancer starr_15671 Neighboring gene STARR-positive B cell enhancer ABC_E6425 Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene predicted gene 7554

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (24)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 43
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables MAP kinase kinase activity  
    enables MAP kinase kinase activity  
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables mitogen-activated protein kinase kinase binding  
    enables mitogen-activated protein kinase kinase binding  
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables ribosomal protein S6 kinase activity  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables small GTPase binding  
    enables small GTPase binding  
    Items 1 - 25 of 43
    Items 1 - 25 of 62
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment PubMed 
    acts_upstream_of_or_within CD4-positive, alpha-beta T cell differentiation PubMed 
    acts_upstream_of ERK1 and ERK2 cascade PubMed 
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    acts_upstream_of_or_within T cell differentiation in thymus PubMed 
    acts_upstream_of_or_within T cell receptor signaling pathway PubMed 
    acts_upstream_of_or_within alpha-beta T cell differentiation PubMed 
    acts_upstream_of_or_within cell differentiation PubMed 
    involved_in cellular response to calcium ion  
    involved_in cellular response to calcium ion  
    involved_in cellular response to nerve growth factor stimulus  
    acts_upstream_of_or_within cellular response to xenobiotic stimulus PubMed 
    involved_in chromatin remodeling  
    acts_upstream_of endothelial cell apoptotic process PubMed 
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in establishment of protein localization to membrane  
    involved_in establishment of protein localization to membrane  
    acts_upstream_of_or_within face development PubMed 
    acts_upstream_of_or_within head morphogenesis PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation PubMed 
    acts_upstream_of_or_within myeloid progenitor cell differentiation PubMed 
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast migration PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of neuron apoptotic process  
    acts_upstream_of_or_within negative regulation of synaptic vesicle exocytosis PubMed 
    acts_upstream_of_or_within positive T cell selection PubMed 
    involved_in positive regulation of D-glucose transmembrane transport  
    involved_in positive regulation of D-glucose transmembrane transport  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within positive regulation of axon regeneration PubMed 
    acts_upstream_of_or_within positive regulation of axonogenesis PubMed 
    acts_upstream_of_or_within positive regulation of axonogenesis PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    acts_upstream_of_or_within positive regulation of stress fiber assembly PubMed 
    acts_upstream_of_or_within positive regulation of stress fiber assembly PubMed 
    acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    acts_upstream_of_or_within regulation of T cell differentiation PubMed 
    acts_upstream_of_or_within regulation of axon regeneration PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in response to cAMP  
    involved_in response to cAMP  
    involved_in response to peptide hormone  
    involved_in response to peptide hormone  
    acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
    acts_upstream_of stress fiber assembly PubMed 
    acts_upstream_of substrate adhesion-dependent cell spreading PubMed 
    acts_upstream_of synaptic vesicle exocytosis PubMed 
    acts_upstream_of_or_within thymus development PubMed 
    acts_upstream_of_or_within thyroid gland development PubMed 
    acts_upstream_of_or_within visual learning PubMed 
    Items 1 - 25 of 62
    Component Evidence Code Pubs
    located_in cell body PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in intracellular membrane-bounded organelle  
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in neuron projection PubMed 
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in postsynapse  
    located_in presynapse  

    General protein information

    Preferred Names
    serine/threonine-protein kinase B-raf
    Names
    B-Raf proto-oncogene serine/threonine-protein kinase (p94)
    proto-oncogene B-Raf
    NP_647455.3
    XP_006505416.1
    XP_006505418.1
    XP_006505421.1
    XP_011239436.1
    XP_011239437.1
    XP_011239438.2
    XP_011239439.2
    XP_011239440.1
    XP_011239441.1
    XP_030110954.1
    XP_030110955.1
    XP_036021639.1
    XP_036021640.1
    XP_036021641.1
    XP_036021642.1
    XP_036021643.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139294.5NP_647455.3  serine/threonine-protein kinase B-raf

      See identical proteins and their annotated locations for NP_647455.3

      Status: VALIDATED

      Source sequence(s)
      AC122345, AC163109, AK140431, BF466677, CK393545
      Consensus CDS
      CCDS39463.1
      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Related
      ENSMUSP00000002487.9, ENSMUST00000002487.15
      Conserved Domains (4) summary
      cd01816
      Location:140211
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14062
      Location:500752
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      pfam00069
      Location:495750
      Pkinase; Protein kinase domain
      pfam00130
      Location:219264
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39580171..39702592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165750.1XP_036021643.1  serine/threonine-protein kinase B-raf isoform X16

      Conserved Domains (3) summary
      cd14062
      Location:558804
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248326
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:324383
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    2. XM_006505358.5XP_006505421.1  serine/threonine-protein kinase B-raf isoform X13

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Related
      ENSMUSP00000099036.4, ENSMUST00000101497.4
      Conserved Domains (3) summary
      cd14062
      Location:558810
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248326
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:329374
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    3. XM_006505355.5XP_006505418.1  serine/threonine-protein kinase B-raf isoform X5

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:598850
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248326
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:329374
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    4. XM_036165747.1XP_036021640.1  serine/threonine-protein kinase B-raf isoform X10

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:570822
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248326
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:324383
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    5. XM_006505353.5XP_006505416.1  serine/threonine-protein kinase B-raf isoform X3

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:610862
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248326
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:329374
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    6. XM_011241139.4XP_011239441.1  serine/threonine-protein kinase B-raf isoform X12

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:561813
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248329
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:332377
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    7. XM_011241135.4XP_011239437.1  serine/threonine-protein kinase B-raf isoform X4

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:601853
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248329
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:332377
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    8. XM_011241138.4XP_011239440.1  serine/threonine-protein kinase B-raf isoform X8

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:573825
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248329
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:332377
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    9. XM_011241134.4XP_011239436.1  serine/threonine-protein kinase B-raf isoform X1

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:613865
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248329
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:332377
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    10. XM_036165746.1XP_036021639.1  serine/threonine-protein kinase B-raf isoform X2

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:613865
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:248329
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:327386
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    11. XM_011241137.3XP_011239439.2  serine/threonine-protein kinase B-raf isoform X7

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:574826
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:209290
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:293338
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    12. XM_011241136.4XP_011239438.2  serine/threonine-protein kinase B-raf isoform X6

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:580832
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:215296
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:299344
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    13. XM_030255094.2XP_030110954.1  serine/threonine-protein kinase B-raf isoform X9

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:571823
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:209287
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:290335
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    14. XM_036165748.1XP_036021641.1  serine/threonine-protein kinase B-raf isoform X14

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:463715
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:138219
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:217276
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins
    15. XM_030255095.2XP_030110955.1  serine/threonine-protein kinase B-raf isoform X11

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:488740
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:138216
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      pfam00130
      Location:219264
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    16. XM_036165749.1XP_036021642.1  serine/threonine-protein kinase B-raf isoform X15

      UniProtKB/Swiss-Prot
      E9QNG9, F6SZ47, P28028, Q3USE9
      Conserved Domains (3) summary
      cd14062
      Location:448700
      STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
      cd17134
      Location:138216
      RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
      cd20871
      Location:214273
      C1_B-Raf; protein kinase C conserved region 1 (C1 domain) found in B-Raf (Rapidly Accelerated Fibrosarcoma) kinase and similar proteins

    RNA

    1. XR_004942909.1 RNA Sequence

    2. XR_004942908.1 RNA Sequence

    3. XR_001785085.2 RNA Sequence

    4. XR_001785086.3 RNA Sequence

    5. XR_001785087.2 RNA Sequence

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