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    PRI2 DNA primase subunit PRI2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853821, updated on 9-Dec-2024

    Summary

    Official Symbol
    PRI2
    Official Full Name
    DNA primase subunit PRI2
    Primary source
    SGD:S000001528
    Locus tag
    YKL045W
    See related
    AllianceGenome:SGD:S000001528; FungiDB:YKL045W; VEuPathDB:YKL045W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA primase activity and single-stranded DNA binding activity. Involved in DNA replication, synthesis of primer and double-strand break repair. Located in nuclear envelope. Part of alpha DNA polymerase:primase complex. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See PRI2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (353493..355079)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Anr2p Neighboring gene putative mannan endo-1,6-alpha-mannosidase Neighboring gene Mmo1p Neighboring gene Phd1p

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding  
    enables DNA binding  
    contributes_to DNA primase activity PubMed 
    contributes_to DNA primase activity PubMed 
    contributes_to DNA primase activity PubMed 
    enables metal ion binding  
    contributes_to single-stranded DNA binding PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication  
    involved_in DNA replication PubMed 
    involved_in DNA replication initiation  
    involved_in DNA replication, synthesis of primer  
    involved_in DNA replication, synthesis of primer PubMed 
    involved_in DNA replication, synthesis of primer  
    involved_in DNA-templated DNA replication  
    involved_in double-strand break repair PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex  
    part_of alpha DNA polymerase:primase complex PubMed 
    part_of alpha DNA polymerase:primase complex  
    located_in nuclear envelope PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    DNA primase subunit PRI2
    NP_012879.1
    • Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      353493..355079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179611.1 → NP_012879.1  TPA: DNA primase subunit PRI2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012879.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXP2, P20457
      UniProtKB/TrEMBL
      A6ZZS1, G2WHY7, N1P2E5
      Conserved Domains (1) summary
      cd07322
      Location:61 → 507
      PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
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