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    ken ken and barbie [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kenprovided by FlyBase
    Official Full Name
    ken and barbieprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011236
    Locus tag
    Dmel_CG5575
    See related
    AllianceGenome:FB:FBgn0011236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2970; 3907; 5029; 8253; BCL-6/KEN; CG5575; Dmel\CG5575; Ken; KEN; l(2)00628; l(2)02970; l(2)05029; ok; okina; P420
    Summary
    Enables DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including analia development; genitalia development; and negative regulation of receptor signaling pathway via JAK-STAT. Located in nucleus. Is expressed in several structures, including anal pad; auditory system neurons; epithelium; gut section; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ken in Genome Data Viewer
    Location:
    60A6-60A7; 2-105 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23870273..23877442)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19757796..19764965)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ceramide phosphoethanolamine synthase Neighboring gene uncharacterized protein Neighboring gene Mitochondrial trifunctional protein beta subunit Neighboring gene Transmembrane 4 superfamily Neighboring gene uncharacterized protein Neighboring gene Putative homeodomain protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inter and Intraspecific Genomic Divergence in Drosophila montana Shows Evidence for Cold Adaptation. Parker DJ, et al. Genome Biol Evol, 2018 Aug 1. PMID 30010752, Free PMC Article
    2. Analysis of two P-element enhancer-trap insertion lines that show expression in the giant fibre neuron of Drosophila melanogaster. Allen MJ, et al. Genes Brain Behav, 2007 Jun. PMID 16879616
    3. Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. Afonso O, et al. Elife, 2019 Aug 19. PMID 31424385, Free PMC Article
    4. NovoSpaRc: flexible spatial reconstruction of single-cell gene expression with optimal transport. Moriel N, et al. Nat Protoc, 2021 Sep. PMID 34349282
    5. Clustered cell migration: Modeling the model system of Drosophila border cells. Peercy BE, et al. Semin Cell Dev Biol, 2020 Apr. PMID 31837934

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In ken/barbie male flies lacking external genitalia, courtship and physical contact without ejaculation was unable to replicate the mating effect.
      Title: Mechanisms of sleep plasticity due to sexual experience in Drosophila melanogaster.
    2. Data show that that BCL6 homolog ken and barbie (Ken) has an important role in the inhibition of somatic cyst stem cells (CySCs) differentiation.
      Title: The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche.
    3. Ken is a novel regulator of JAK/STAT signaling whose dynamic spatial and temporal expression is capable of selectively modulating the transcriptional repertoire elicited by activated STAT92E in vivo.
      Title: Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes.
    4. Ken and barbie mutants have defects in escape behaviour, behavioural responses to visual stimuli and synaptic functions in the giant fibre system.
      Title: Analysis of two P-element enhancer-trap insertion lines that show expression in the giant fibre neuron of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female analia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male analia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ken and barbie
    Names
    CG5575-PA
    Ken & barbie
    ken-PA
    ken-and-barbie

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23870273..23877442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079109.3 → NP_523833.1  ken and barbie [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77459
      Related
      FBpp0072038
      Conserved Domains (5) summary
      smart00225
      Location:34 → 107
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:502 → 522
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:500 → 522
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:27 → 107
      BTB; BTB/POZ domain
      pfam13465
      Location:514 → 539
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77459.1 O77459

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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