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    Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 [ Mus musculus (house mouse) ]

    Gene ID: 11941, updated on 27-Dec-2024

    Summary

    Official Symbol
    Atp2b2provided by MGI
    Official Full Name
    ATPase, Ca++ transporting, plasma membrane 2provided by MGI
    Primary source
    MGI:MGI:105368
    See related
    Ensembl:ENSMUSG00000030302 AllianceGenome:MGI:105368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmy; dfw; jog; wms; wri; PMCA2; D6Abb2e; Gena300
    Summary
    Enables calcium-dependent ATPase activity. Involved in calcium ion transport; cochlea development; and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; lactation; and neuron differentiation. Located in several cellular components, including apical plasma membrane; endoplasmic reticulum; and neuronal cell body. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and presynaptic membrane. Is expressed in heart; labyrinthine zone; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 82 and autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 49.9), cerebellum adult (RPKM 49.7) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Atp2b2 in Genome Data Viewer
    Location:
    6 E3; 6 52.85 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113720803..114019574, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113743831..114042613, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ghrelin Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component Neighboring gene STARR-seq mESC enhancer starr_17054 Neighboring gene STARR-seq mESC enhancer starr_17055 Neighboring gene predicted gene 15083 Neighboring gene STARR-seq mESC enhancer starr_17060 Neighboring gene predicted gene, 36023 Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 11 Neighboring gene predicted gene, 52916

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables P-type calcium transporter activity  
    enables P-type calcium transporter activity  
    enables P-type calcium transporter activity  
    enables P-type calcium transporter activity  
    enables P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration  
    enables PDZ domain binding  
    enables PDZ domain binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium-dependent ATPase activity PubMed 
    enables calmodulin binding  
    enables calmodulin binding  
    enables glutamate receptor binding  
    enables protein binding  
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    acts_upstream_of_or_within auditory receptor cell stereocilium organization PubMed 
    acts_upstream_of_or_within cGMP metabolic process PubMed 
    involved_in calcium ion transmembrane transport  
    acts_upstream_of_or_within calcium ion transport PubMed 
    involved_in calcium ion transport PubMed 
    involved_in calcium ion transport  
    acts_upstream_of_or_within cell morphogenesis PubMed 
    acts_upstream_of_or_within cerebellar Purkinje cell differentiation PubMed 
    acts_upstream_of_or_within cerebellar Purkinje cell layer morphogenesis PubMed 
    acts_upstream_of_or_within cerebellar granule cell differentiation PubMed 
    acts_upstream_of_or_within cerebellum development PubMed 
    involved_in cochlea development PubMed 
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound PubMed 
    acts_upstream_of_or_within establishment of localization in cell PubMed 
    acts_upstream_of_or_within inner ear development PubMed 
    acts_upstream_of_or_within inner ear morphogenesis PubMed 
    acts_upstream_of_or_within inner ear receptor cell differentiation PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
    acts_upstream_of_or_within lactation PubMed 
    acts_upstream_of_or_within locomotion PubMed 
    acts_upstream_of_or_within locomotory behavior PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance PubMed 
    acts_upstream_of_or_within neuron cellular homeostasis PubMed 
    involved_in neuron differentiation  
    involved_in neuron differentiation  
    acts_upstream_of_or_within organelle organization PubMed 
    acts_upstream_of_or_within otolith mineralization PubMed 
    acts_upstream_of_or_within positive regulation of calcium ion transport PubMed 
    acts_upstream_of_or_within regulation of cell size PubMed 
    involved_in regulation of cytosolic calcium ion concentration  
    involved_in regulation of cytosolic calcium ion concentration PubMed 
    involved_in regulation of cytosolic calcium ion concentration  
    acts_upstream_of_or_within regulation of synaptic plasticity PubMed 
    acts_upstream_of_or_within sensory perception of sound PubMed 
    acts_upstream_of_or_within sensory perception of sound PubMed 
    involved_in sensory perception of sound  
    involved_in sensory perception of sound  
    acts_upstream_of_or_within serotonin metabolic process PubMed 
    acts_upstream_of_or_within synapse organization PubMed 
    Items 1 - 25 of 39
    Items 1 - 20 of 31
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in basolateral plasma membrane  
    located_in cilium PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite  
    located_in dendritic spine membrane  
    located_in dendritic spine membrane  
    located_in endoplasmic reticulum PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    is_active_in intracellular membrane-bounded organelle  
    located_in neuron projection PubMed 
    located_in neuronal cell body PubMed 
    located_in neuronal cell body  
    located_in neuronal cell body membrane  
    is_active_in parallel fiber to Purkinje cell synapse  
    is_active_in photoreceptor ribbon synapse PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic density membrane  
    located_in postsynaptic density membrane  
    is_active_in postsynaptic membrane  
    is_active_in presynaptic active zone membrane  
    is_active_in presynaptic membrane PubMed 
    Items 1 - 20 of 31

    General protein information

    Preferred Names
    plasma membrane calcium-transporting ATPase 2
    Names
    deaf waddler
    plasma membrane calcium ATPase
    plasma membrane calcium pump
    wriggle
    NP_001031761.1
    NP_001334294.1
    NP_001396452.1
    NP_001396453.1
    NP_001396455.1
    NP_001396458.1
    NP_001396462.1
    NP_001396463.1
    NP_001396464.1
    NP_001396465.1
    NP_001396466.1
    NP_033853.1
    XP_011239463.1
    XP_011239464.1
    XP_011239468.1
    XP_011239469.1
    XP_011239470.1
    XP_011239471.1
    XP_011239472.1
    XP_030110979.1
    XP_030110980.1
    XP_030110982.1
    XP_036021655.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001036684.4NP_001031761.1  plasma membrane calcium-transporting ATPase 2 isoform 1

      See identical proteins and their annotated locations for NP_001031761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 3. These differences result in a shorter protein (isoform 1), compared to isoform 2. Variants 1, 2, 6, and 7 all encode the same isoform (1).
      Source sequence(s)
      AC117596
      Consensus CDS
      CCDS20433.1
      UniProtKB/Swiss-Prot
      O88863, Q9R0K7
      UniProtKB/TrEMBL
      D5L240, Q3UHJ3
      Related
      ENSMUSP00000086398.6, ENSMUST00000089003.12
      Conserved Domains (2) summary
      TIGR01517
      Location:121042
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10811127
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    2. NM_001347365.2NP_001334294.1  plasma membrane calcium-transporting ATPase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes isoform 2. Variants 3 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC117596, AC153590
      Consensus CDS
      CCDS85130.1
      UniProtKB/TrEMBL
      D5L240, F8WHB1
      Related
      ENSMUSP00000098605.3, ENSMUST00000101044.9
      Conserved Domains (2) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11261172
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    3. NM_001409523.1NP_001396452.1  plasma membrane calcium-transporting ATPase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117596
      UniProtKB/TrEMBL
      D5L240, F8WHB1
    4. NM_001409524.1NP_001396453.1  plasma membrane calcium-transporting ATPase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117596, AC153590
      UniProtKB/TrEMBL
      D5L240
    5. NM_001409526.1NP_001396455.1  plasma membrane calcium-transporting ATPase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117596, AC153590
      UniProtKB/Swiss-Prot
      O88863, Q9R0K7
      UniProtKB/TrEMBL
      D5L240, Q3UHJ3
    6. NM_001409529.1NP_001396458.1  plasma membrane calcium-transporting ATPase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117596, AC153590
      UniProtKB/Swiss-Prot
      O88863, Q9R0K7
      UniProtKB/TrEMBL
      D5L240, Q3UHJ3
    7. NM_001409533.1NP_001396462.1  plasma membrane calcium-transporting ATPase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117596
      UniProtKB/TrEMBL
      D5L240, Q3UHH0
      Related
      ENSMUSP00000145174.2, ENSMUST00000205052.3
    8. NM_001409534.1NP_001396463.1  plasma membrane calcium-transporting ATPase 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117596
      UniProtKB/TrEMBL
      D5L240
    9. NM_001409535.1NP_001396464.1  plasma membrane calcium-transporting ATPase 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC117596
      UniProtKB/TrEMBL
      D5L240
    10. NM_001409536.1NP_001396465.1  plasma membrane calcium-transporting ATPase 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC117596
      UniProtKB/TrEMBL
      D5L240, S4R1C4
    11. NM_001409537.1NP_001396466.1  plasma membrane calcium-transporting ATPase 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC117596
      UniProtKB/TrEMBL
      D5L240, S4R1C4
    12. NM_009723.7NP_033853.1  plasma membrane calcium-transporting ATPase 2 isoform 1

      See identical proteins and their annotated locations for NP_033853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding region, compared to variant 3. These differences result in a shorter protein (isoform 1), compared to isoform 2. Variants 1, 2, 6, and 7 all encode the same isoform (1).
      Source sequence(s)
      AC117596, AC153590
      Consensus CDS
      CCDS20433.1
      UniProtKB/Swiss-Prot
      O88863, Q9R0K7
      UniProtKB/TrEMBL
      D5L240, Q3UHJ3
      Related
      ENSMUSP00000098606.4, ENSMUST00000101045.10
      Conserved Domains (2) summary
      TIGR01517
      Location:121042
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10811127
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    RNA

    1. NR_176856.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117596, AC153590

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      113720803..114019574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241161.1XP_011239463.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_011239463.1

      UniProtKB/TrEMBL
      D5L240, F8WHB1
      Conserved Domains (2) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11261172
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    2. XM_011241167.3XP_011239469.1  plasma membrane calcium-transporting ATPase 2 isoform X4

      UniProtKB/TrEMBL
      D5L240
      Conserved Domains (2) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11261168
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    3. XM_011241168.2XP_011239470.1  plasma membrane calcium-transporting ATPase 2 isoform X5

      UniProtKB/TrEMBL
      D5L240
      Conserved Domains (2) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11261168
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    4. XM_030255122.2XP_030110982.1  plasma membrane calcium-transporting ATPase 2 isoform X10

      UniProtKB/TrEMBL
      D5L240
      Conserved Domains (2) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11261201
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    5. XM_011241162.4XP_011239464.1  plasma membrane calcium-transporting ATPase 2 isoform X1

      See identical proteins and their annotated locations for XP_011239464.1

      UniProtKB/TrEMBL
      D5L240, F8WHB1
      Conserved Domains (2) summary
      TIGR01517
      Location:121087
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11261172
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    6. XM_011241166.4XP_011239468.1  plasma membrane calcium-transporting ATPase 2 isoform X3

      UniProtKB/TrEMBL
      D5L240
      Conserved Domains (2) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10951141
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    7. XM_030255120.2XP_030110980.1  plasma membrane calcium-transporting ATPase 2 isoform X3

      UniProtKB/TrEMBL
      D5L240
      Conserved Domains (2) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10951141
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    8. XM_030255119.2XP_030110979.1  plasma membrane calcium-transporting ATPase 2 isoform X2

      UniProtKB/TrEMBL
      D5L240
      Conserved Domains (2) summary
      TIGR01517
      Location:121073
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:11121158
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    9. XM_036165762.1XP_036021655.1  plasma membrane calcium-transporting ATPase 2 isoform X9

      UniProtKB/TrEMBL
      D5L240, S4R1C4
      Related
      ENSMUSP00000138165.2, ENSMUST00000152831.8
      Conserved Domains (2) summary
      TIGR01517
      Location:121042
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10811123
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    10. XM_011241170.2XP_011239472.1  plasma membrane calcium-transporting ATPase 2 isoform X8

      UniProtKB/TrEMBL
      D5L240
      Conserved Domains (2) summary
      TIGR01517
      Location:121042
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10811123
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    11. XM_011241169.3XP_011239471.1  plasma membrane calcium-transporting ATPase 2 isoform X7

      UniProtKB/TrEMBL
      D5L240
      Conserved Domains (2) summary
      TIGR01517
      Location:121056
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:10951137
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    RNA

    1. XR_868849.2 RNA Sequence

    2. XR_001785094.3 RNA Sequence

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