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    Homer1 homer scaffolding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 26556, updated on 9-Dec-2024

    Summary

    Official Symbol
    Homer1provided by MGI
    Official Full Name
    homer scaffolding protein 1provided by MGI
    Primary source
    MGI:MGI:1347345
    See related
    Ensembl:ENSMUSG00000007617 AllianceGenome:MGI:1347345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SYN47; Ves-1; vesl-1; homer-1; PSD-Zip45
    Summary
    Predicted to enable several functions, including scaffold protein binding activity; transmembrane transporter binding activity; and type 5 metabotropic glutamate receptor binding activity. Predicted to be a structural constituent of postsynapse. Involved in regulation of monoatomic ion transport and regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within several processes, including behavioral response to cocaine; skeletal muscle contraction; and skeletal muscle fiber development. Located in several cellular components, including apical part of cell; myofibril; and postsynapse. Is active in glutamatergic synapse; postsynaptic cytosol; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human HOMER1 (homer scaffold protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 6.9), frontal lobe adult (RPKM 5.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Homer1 in Genome Data Viewer
    Location:
    13 C3; 13 47.83 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (93440265..93549471)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (93303757..93405129)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41020 Neighboring gene STARR-seq mESC enhancer starr_35279 Neighboring gene STARR-seq mESC enhancer starr_35280 Neighboring gene STARR-positive B cell enhancer mm9_chr13:94013261-94013562 Neighboring gene STARR-positive B cell enhancer ABC_E7265 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:94164399-94164636 Neighboring gene STARR-seq mESC enhancer starr_35281 Neighboring gene family with sequence similarity 113, member B pseudogene Neighboring gene junction-mediating and regulatory protein Neighboring gene predicted gene 6109

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled glutamate receptor binding  
    enables G protein-coupled glutamate receptor binding  
    enables identical protein binding  
    enables molecular adaptor activity  
    enables molecular adaptor activity  
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables signaling receptor binding  
    enables structural constituent of postsynapse  
    enables structural constituent of postsynapse  
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    enables type 5 metabotropic glutamate receptor binding  
    enables type 5 metabotropic glutamate receptor binding  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway  
    involved_in G protein-coupled glutamate receptor signaling pathway  
    acts_upstream_of_or_within G protein-coupled glutamate receptor signaling pathway PubMed 
    acts_upstream_of_or_within behavioral response to cocaine PubMed 
    involved_in circadian rhythm  
    acts_upstream_of_or_within positive regulation of calcium ion transport PubMed 
    involved_in postsynapse organization  
    involved_in protein localization to synapse  
    involved_in protein localization to synapse  
    involved_in protein tetramerization  
    involved_in protein tetramerization  
    involved_in regulation of calcium ion import PubMed 
    involved_in regulation of cation channel activity PubMed 
    involved_in regulation of dendritic spine maintenance  
    involved_in regulation of dendritic spine maintenance  
    involved_in regulation of postsynaptic neurotransmitter receptor activity PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor activity PubMed 
    involved_in regulation of store-operated calcium entry  
    involved_in regulation of store-operated calcium entry PubMed 
    involved_in regulation of synaptic transmission, glutamatergic  
    involved_in regulation of synaptic transmission, glutamatergic  
    involved_in response to calcium ion  
    involved_in response to calcium ion  
    involved_in response to nicotine  
    acts_upstream_of_or_within skeletal muscle contraction PubMed 
    acts_upstream_of_or_within skeletal muscle fiber development PubMed 
    Items 1 - 25 of 26
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    located_in Z disc PubMed 
    located_in apical part of cell PubMed 
    located_in axon PubMed 
    located_in costamere PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in dendrite  
    located_in dendrite  
    located_in dendritic shaft  
    located_in dendritic shaft  
    located_in dendritic spine  
    located_in dendritic spine  
    located_in excitatory synapse  
    located_in excitatory synapse  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in membrane PubMed 
    located_in neuron projection PubMed 
    located_in neuron projection PubMed 
    located_in neuron spine  
    located_in neuron spine  
    located_in neuronal cell body  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in postsynapse PubMed 
    is_active_in postsynaptic cytosol PubMed 
    is_active_in postsynaptic density  
    is_active_in postsynaptic density PubMed 
    located_in postsynaptic density PubMed 
    located_in postsynaptic density PubMed 
    is_active_in postsynaptic density  
    located_in postsynaptic density  
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    homer protein homolog 1
    Names
    VASP/Ena-related gene up-regulated during seizure and LTP 1
    homer homolog 1
    homer, neuronal immediate early gene, 1
    immediate early gene protein Homer1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284189.2NP_001271118.1  homer protein homolog 1 isoform b

      See identical proteins and their annotated locations for NP_001271118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b, also known as homer-1b) lacks an alternate in-frame exon in the central coding region, compared to variant L. The encoded isoform (b) is shorter than isoform L.
      Source sequence(s)
      AC154231, AF093258, AK137151, BY644449, CJ130737
      Consensus CDS
      CCDS70484.1
      UniProtKB/Swiss-Prot
      Q9Z2Y3
      UniProtKB/TrEMBL
      Q3UVL6
      Related
      ENSMUSP00000050471.5, ENSMUST00000060490.11
      Conserved Domains (2) summary
      COG1196
      Location:157352
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    2. NM_001347598.1NP_001334527.1  homer protein homolog 1 isoform M

      Status: VALIDATED

      Description
      Transcript Variant: This variant (M, also known as Vesl-1M) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant L. The encoded isoform (M) has a shorter and distinct C-terminus, compared to isoform L.
      Source sequence(s)
      AC120347, AK137151, BB448191, CJ130737, CJ133579
      Consensus CDS
      CCDS84048.1
      UniProtKB/TrEMBL
      Q3UVL6
      Related
      ENSMUSP00000105118.2, ENSMUST00000109492.9
    3. NM_011982.4NP_036112.1  homer protein homolog 1 isoform S

      See identical proteins and their annotated locations for NP_036112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (S, also known as homer-1a or Vesl-1S) lacks several 3' exons but contains a 3' terminal exon that extends past a splice site that is used in variant L, resulting in a novel 3' coding region and 3' UTR, compared to variant L. The encoded isoform (S) has a shorter and distinct C-terminus, compared to isoform L.
      Source sequence(s)
      AF093257, AK137151, BC064041, CJ130737
      Consensus CDS
      CCDS26687.1
      UniProtKB/TrEMBL
      D3Z6A8, Q5D052
      Related
      ENSMUSP00000099813.4, ENSMUST00000102752.10
      Conserved Domains (1) summary
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    4. NM_147176.4NP_671705.2  homer protein homolog 1 isoform L

      See identical proteins and their annotated locations for NP_671705.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (L, also known as Vesl-1L) represents the longest transcript and encodes isoform L.
      Source sequence(s)
      AB019479, AC154231, AF093258, AK137151, BY644449, CJ130737
      Consensus CDS
      CCDS36745.1
      UniProtKB/Swiss-Prot
      Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216, Q9Z2Y3
      Related
      ENSMUSP00000079026.6, ENSMUST00000080127.12
      Conserved Domains (2) summary
      COG1196
      Location:187364
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    5. NM_152134.3NP_687036.1  homer protein homolog 1 isoform d

      See identical proteins and their annotated locations for NP_687036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d, also known as homer-1d) uses an alternate 5'-terminal exon, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant L. The encoded isoform (d) has a distinct N-terminus and is longer than isoform L.
      Source sequence(s)
      AC120347, AC154231, AF093258
      Consensus CDS
      CCDS36746.1
      UniProtKB/Swiss-Prot
      Q9Z2Y3
      Related
      ENSMUSP00000078093.7, ENSMUST00000079086.8
      Conserved Domains (3) summary
      cd01206
      Location:19127
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl12013
      Location:206349
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19219
      Location:264334
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      93440265..93549471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158052.1XP_036013945.1  homer protein homolog 1 isoform X1

      Conserved Domains (2) summary
      COG1196
      Location:203380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:19127
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
    2. XM_036158053.1XP_036013946.1  homer protein homolog 1 isoform X2

      Conserved Domains (1) summary
      cd01206
      Location:19127
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
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