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    E2F2 E2F transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 1870, updated on 10-Dec-2024

    Summary

    Official Symbol
    E2F2provided by HGNC
    Official Full Name
    E2F transcription factor 2provided by HGNC
    Primary source
    HGNC:HGNC:3114
    See related
    Ensembl:ENSG00000007968 MIM:600426; AllianceGenome:HGNC:3114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2F-2
    Summary
    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in bone marrow (RPKM 17.6), lymph node (RPKM 3.1) and 8 other tissues See more
    Orthologs
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    Genomic context

    See E2F2 in Genome Data Viewer
    Location:
    1p36.12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23505212..23531233, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23339773..23365799, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23832930..23857725, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23709609-23709825 Neighboring gene transcription elongation factor A3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 363 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23745635-23746193 Neighboring gene uncharacterized LOC124903875 Neighboring gene Sharpr-MPRA regulatory region 12987 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23800831-23801332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23801333-23801832 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 412 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:23829854-23830688 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:23830689-23831522 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:23847293-23848492 Neighboring gene uncharacterized LOC101928163 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23854779-23854975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 365 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23857131-23857279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 415 Neighboring gene Sharpr-MPRA regulatory region 6048 Neighboring gene uncharacterized LOC124903876 Neighboring gene Sharpr-MPRA regulatory region 7496 Neighboring gene uncharacterized LOC105376859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23875384-23875934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 366 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23886059-23886305 Neighboring gene inhibitor of DNA binding 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex PubMed 
    part_of RNA polymerase II transcription regulator complex  
    part_of Rb-E2F complex  
    located_in chromatin  
    located_in nucleoplasm  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004091.4 → NP_004082.1  transcription factor E2F2

      See identical proteins and their annotated locations for NP_004082.1

      Status: REVIEWED

      Source sequence(s)
      AF086395, AL021154, L22846
      Consensus CDS
      CCDS236.1
      UniProtKB/Swiss-Prot
      B2R9W1, Q14209, Q7Z6H1
      UniProtKB/TrEMBL
      Q5U0J0
      Related
      ENSP00000355249.2, ENST00000361729.3
      Conserved Domains (2) summary
      cd14660
      Location:206 → 306
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:131 → 194
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      23505212..23531233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448092.1 → XP_047304048.1  transcription factor E2F2 isoform X4

    2. XM_011540870.4 → XP_011539172.1  transcription factor E2F2 isoform X3

      Conserved Domains (1) summary
      cd14660
      Location:206 → 306
      E2F_DD; Dimerization domain of E2F transcription factors
    3. XM_047448091.1 → XP_047304047.1  transcription factor E2F2 isoform X2

      UniProtKB/TrEMBL
      Q5U0J0
    4. XM_011540871.3 → XP_011539173.1  transcription factor E2F2 isoform X6

      See identical proteins and their annotated locations for XP_011539173.1

      Conserved Domains (1) summary
      cd14660
      Location:10 → 110
      E2F_DD; Dimerization domain of E2F transcription factors
    5. XM_011540868.4 → XP_011539170.1  transcription factor E2F2 isoform X1

      UniProtKB/TrEMBL
      Q5U0J0
      Conserved Domains (2) summary
      cd14660
      Location:204 → 304
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:131 → 194
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    6. XM_047448093.1 → XP_047304049.1  transcription factor E2F2 isoform X6

    7. XM_047448094.1 → XP_047304050.1  transcription factor E2F2 isoform X6

    8. XM_005245749.4 → XP_005245806.1  transcription factor E2F2 isoform X6

      See identical proteins and their annotated locations for XP_005245806.1

      Conserved Domains (1) summary
      cd14660
      Location:10 → 110
      E2F_DD; Dimerization domain of E2F transcription factors
    9. XM_005245748.4 → XP_005245805.1  transcription factor E2F2 isoform X5

      Conserved Domains (1) summary
      cd14660
      Location:18 → 118
      E2F_DD; Dimerization domain of E2F transcription factors

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_014040926.1 Reference GRCh38.p14 PATCHES

      Range
      275191..301212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331916.1 → XP_054187891.1  transcription factor E2F2 isoform X4

    2. XM_054331915.1 → XP_054187890.1  transcription factor E2F2 isoform X3

    3. XM_054331914.1 → XP_054187889.1  transcription factor E2F2 isoform X2

      UniProtKB/TrEMBL
      Q5U0J0
    4. XM_054331913.1 → XP_054187888.1  transcription factor E2F2 isoform X1

      UniProtKB/TrEMBL
      Q5U0J0
    5. XM_054331918.1 → XP_054187893.1  transcription factor E2F2 isoform X6

    6. XM_054331917.1 → XP_054187892.1  transcription factor E2F2 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23339773..23365799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334810.1 → XP_054190785.1  transcription factor E2F2 isoform X4

    2. XM_054334809.1 → XP_054190784.1  transcription factor E2F2 isoform X3

    3. XM_054334808.1 → XP_054190783.1  transcription factor E2F2 isoform X2

      UniProtKB/TrEMBL
      Q5U0J0
    4. XM_054334807.1 → XP_054190782.1  transcription factor E2F2 isoform X1

      UniProtKB/TrEMBL
      Q5U0J0
    5. XM_054334812.1 → XP_054190787.1  transcription factor E2F2 isoform X6

    6. XM_054334811.1 → XP_054190786.1  transcription factor E2F2 isoform X5

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