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    HNT3 DNA 5'-adenosine monophosphate hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HNT3
    Official Full Name
    DNA 5'-adenosine monophosphate hydrolase
    Primary source
    SGD:S000005784
    Locus tag
    YOR258W
    See related
    AllianceGenome:SGD:S000005784; FungiDB:YOR258W; VEuPathDB:YOR258W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA 5'-adenosine monophosphate hydrolase activity. Involved in DNA damage response. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 1 and olivopontocerebellar atrophy. Orthologous to human APTX (aprataxin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HNT3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (811671..812324)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative zinc metalloprotease Neighboring gene centrin Neighboring gene proteasome regulatory particle base subunit RPT4 Neighboring gene translation initiation factor eIF2B subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity. Tumbale P, et al. Nature, 2014 Feb 6. PMID 24362567, Free PMC Article
    2. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. Bieganowski P, et al. J Biol Chem, 2002 Mar 29. PMID 11805111, Free PMC Article
    3. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Ahel I, et al. Nature, 2006 Oct 12. PMID 16964241
    4. Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair. Daley JM, et al. DNA Repair (Amst), 2010 Jun 4. PMID 20399152, Free PMC Article
    5. Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability. Peng J, et al. Nucleic Acids Res, 2016 Dec 1. PMID 27536003, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA 5'-adenosine monophosphate hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA 5'-adenosine monophosphate hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA 5'-adenosine monophosphate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-3'-diphospho-5'-guanosine diphosphatase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-strand break-containing DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in single strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA 5'-adenosine monophosphate hydrolase
    NP_014901.1
    • DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      811671..812324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183677.1 → NP_014901.1  TPA: DNA 5'-adenosine monophosphate hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014901.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2V9, Q05189, Q08702
      UniProtKB/TrEMBL
      B3LJS6, C7GWD1, C8ZH09, N1NYS3
      Conserved Domains (2) summary
      pfam01230
      Location:15 → 139
      HIT; HIT domain
      pfam16278
      Location:153 → 212
      zf-C2HE; C2HE / C2H2 / C2HC zinc-binding finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08702.1

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