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    Ecm2 extracellular matrix protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361383, updated on 27-Nov-2024

    Summary

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    Symbol
    Ecm2provided by RGD
    Full Name
    extracellular matrix protein 2provided by RGD
    Primary source
    RGD:2320282
    See related
    EnsemblRapid:ENSRNOG00000031716 AllianceGenome:RGD:2320282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable collagen V binding activity and heparin binding activity. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to be located in interstitial matrix. Orthologous to human ECM2 (extracellular matrix protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 117.5), Muscle (RPKM 108.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ecm2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (15326359..15358938, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (15120194..15152536, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (15533760..15566403, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene asporin Neighboring gene ribosomal protein L6, pseudogene 6 Neighboring gene uncharacterized LOC134482692 Neighboring gene inositol-pentakisphosphate 2-kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen V binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen V binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell-substrate adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interstitial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    extracellular matrix protein 2
    Names
    extracellular matrix protein 2, female organ and adipocyte specific

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427107.1 → NP_001414036.1  extracellular matrix protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      D3ZS41
      Related
      ENSRNOP00000076346.1, ENSRNOT00000093743.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      15326359..15358938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253742.5 → XP_006253804.1  extracellular matrix protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006253804.1

      UniProtKB/TrEMBL
      A6J6W1
      Conserved Domains (4) summary
      cd00116
      Location:262 → 522
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:189 → 212
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:187 → 225
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:187 → 249
      LRR_8; Leucine rich repeat

    2. XM_039096237.2 → XP_038952165.1  extracellular matrix protein 2 isoform X1

      UniProtKB/TrEMBL
      A6J6W1, D3ZS41
      Conserved Domains (4) summary
      COG4886
      Location:237 → 478
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:252 → 275
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00093
      Location:100 → 154
      VWC; von Willebrand factor type C domain
      pfam13855
      Location:488 → 550
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
    Molecular Biology Databases
    Research Materials