Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnh5provided by MGI
Official Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 5provided by MGI
Primary source: MGI:MGI:3584508
See related: Ensembl:ENSMUSG00000034402 AllianceGenome:MGI:3584508
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eag2; mEag2
Summary: Predicted to enable delayed rectifier potassium channel activity and transmembrane transporter binding activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to act upstream of or within regulation of G2/M transition of mitotic cell cycle. Predicted to be located in cell surface. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood vessel; central nervous system; eye; genitourinary system; and thymus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human KCNH5 (potassium voltage-gated channel subfamily H member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 2.7), frontal lobe adult (RPKM 1.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 32.62 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (74943991..75224625, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (74897217..75177332, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of EAG2 expression results in G2 arrest and mitotic catastrophe associated with failure of premitotic cytoplasmic condensation
Title: Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics.
Our results suggest close conformational conservation between closed EAG (Kv12.1 and Kv10.2) and Shaker family channels, despite large differences in voltage sensitivity, activation rates, and activation threshold
Title: Divalent cations slow activation of EAG family K+ channels through direct binding to S4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S1251 (e-PCR)
- UniSTS:20030

Kcnh5 (e-PCR), detects polymorphism
- UniSTS:496048

31.MMHAP7FLC4.seq (e-PCR)
- UniSTS:186304

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular anatomical structure	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: voltage-gated delayed rectifier potassium channel KCNH5; potassium voltage-gated channel subfamily H member 5

Names: ether-a-go-go potassium channel 2; voltage-gated potassium channel subunit Kv10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172805.3 → NP_766393.2 voltage-gated delayed rectifier potassium channel KCNH5

See identical proteins and their annotated locations for NP_766393.2

Status: VALIDATED

Source sequence(s)

AC110175, AC131762, AK032438, CT010432

Consensus CDS

CCDS25980.1

UniProtKB/Swiss-Prot

E9QPM0, Q8C035, Q920E3

UniProtKB/TrEMBL

Q6NZH0

Related

ENSMUSP00000046864.3, ENSMUST00000042299.4

Conserved Domains (6) summary

COG0664
Location:544 → 723

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:550 → 660

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:37 → 131

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:232 → 479

Ion_trans; Ion transport protein

pfam07885
Location:419 → 473

Ion_trans_2; Ion channel

pfam08447
Location:40 → 127

PAS_3; PAS fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

74943991..75224625 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157403.1 → XP_036013296.1 potassium voltage-gated channel subfamily H member 5 isoform X1

Conserved Domains (2) summary

pfam00520
Location:217 → 479

Ion_trans; Ion transport protein

pfam13426
Location:39 → 132

PAS_9; PAS domain