CDC33 translation initiation factor eIF4E [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CDC33
Official Full Name: translation initiation factor eIF4E
Primary source: SGD:S000005499
Locus tag: YOL139C
See related: AllianceGenome:SGD:S000005499; FungiDB:YOL139C; VEuPathDB:YOL139C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TIF45
Summary: Enables mRNA cap binding activity and phosphatidylinositol-3-phosphate binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of formation of translation preinitiation complex; and regulation of cell cycle. Located in cytoplasmic stress granule and nucleus. Part of eukaryotic translation initiation factor 4F complex. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autism spectrum disorder and autistic disorder. Orthologous to several human genes including EIF4E (eukaryotic translation initiation factor 4E). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CDC33 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (60383..61024, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The domains of yeast eIF4G, eIF4E and the cap fine-tune eIF4A activities through an intricate network of stimulatory and inhibitory effects.
Title: The domains of yeast eIF4G, eIF4E and the cap fine-tune eIF4A activities through an intricate network of stimulatory and inhibitory effects.
mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation.
Title: mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation.
Overlapping regions of Caf20 mediate its interactions with the mRNA-5'cap-binding protein eIF4E and with ribosomes.
Title: Overlapping regions of Caf20 mediate its interactions with the mRNA-5'cap-binding protein eIF4E and with ribosomes.
Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo.
Title: Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo.
We propose that the eIF4E/p20/mRNA complex serves as a stable depository of mRNAs existing in a dynamic equilibrium with other complexes such as eIF4E/eIF4G (required for translation) and eIF4E/Eap1 (required for mRNA degradation)
Title: Properties of the ternary complex formed by yeast eIF4E, p20 and mRNA.
Crystal structures of the yeast eIF4E bound to two yeast 4E-BPs, p20 and Eap1p, as well as crystal structures of a fungal eIF4E-eIF4G complex, were determined. Highly specialized structural motifs serve to modulate the affinity of protein-protein interactions regulating cap-dependent translation initiation in fungi.The canonical and non-canonical motifs in 4E-BPs and eIF4G contribute differently to the affinity for eIF4E.
Title: Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
Closed-loop model of mRNA translation is prevalent for eIF4E/4G-bound but unexpectedly sparse for PAB1-bound mRNAs.
Title: Probing the closed-loop model of mRNA translation in living cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA cap binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of formation of translation preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 4F complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: translation initiation factor eIF4E

NP_014502.1

Translation initiation factor eIF4E; mRNA cap binding protein and subunit of the mRNA cap-binding complex (eIF4F) along with eIF4A (Tif1p/Tif2p) and eIF4G (Tif4631p/Tif4632p), that mediates cap-dependent translation; required with eIF4G for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; protein abundance increases in response to DNA replication stress; human homolog EIF4E can complement the cdc33 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

60383..61024 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183393.1 → NP_014502.1 TPA: translation initiation factor eIF4E [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014502.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1T0, P07260

UniProtKB/TrEMBL

A6ZN73, B3LIS8, B5VRC2, C7GV14, C8ZHH8, G2WM99, N1NWK0

Conserved Domains (1) summary

COG5053
Location:1 → 213

CDC33; Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis]