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    Sgt small glutamine-rich tetratricopeptide containing protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgtprovided by FlyBase
    Official Full Name
    small glutamine-rich tetratricopeptide containing proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032640
    Locus tag
    Dmel_CG5094
    See related
    AllianceGenome:FB:FBgn0032640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5094; Dmel\CG5094; dsgt; sgt
    Summary
    Predicted to enable molecular adaptor activity. Involved in positive regulation of chaperone-mediated protein folding. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in adult head and organism. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha) and SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sgt in Genome Data Viewer
    Location:
    36C9-36C9; 2-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17471603..17474773)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17471603..17474773)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Serine protease homolog 93 Neighboring gene uncharacterized protein Neighboring gene Bicaudal D Neighboring gene cassowary Neighboring gene four way stop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. Koch R, et al. PLoS One, 2009. PMID 19234596, Free PMC Article
    2. Cysteine string proteins. Gundersen CB. Prog Neurobiol, 2020 May. PMID 32044380
    3. Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy. Khan A, et al. BMC Biol, 2020 Feb 14. PMID 32059717, Free PMC Article
    4. Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome after Perturbation of the Proteasome by Targeted dsRNA-Mediated Subunit Knockdown in Drosophila. Sap KA, et al. J Proteome Res, 2017 Aug 4. PMID 28665616
    5. Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy. Uytterhoeven V, et al. Neuron, 2015 Nov 18. PMID 26590345

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TRC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small glutamine-rich tetratricopeptide containing protein
    Names
    CG5094-PA
    CG5094-PB
    Sgt-PA
    Sgt-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17471603..17474773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259129.2 → NP_001246058.1  small glutamine-rich tetratricopeptide containing protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJD4
      Conserved Domains (7) summary
      sd00006
      Location:116 → 144
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:184 → 217
      TPR_1; Tetratricopeptide repeat
      pfam07719
      Location:116 → 149
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:116 → 177
      TPR_11; TPR repeat
      pfam13431
      Location:139 → 170
      TPR_17; Tetratricopeptide repeat
      pfam13432
      Location:156 → 218
      TPR_16; Tetratricopeptide repeat
      pfam16546
      Location:9 → 48
      SGTA_dimer; Homodimerization domain of SGTA

    2. NM_135998.3 → NP_609842.1  small glutamine-rich tetratricopeptide containing protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJD4
      Related
      FBpp0080535
      Conserved Domains (7) summary
      sd00006
      Location:116 → 144
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:184 → 217
      TPR_1; Tetratricopeptide repeat
      pfam07719
      Location:116 → 149
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:116 → 177
      TPR_11; TPR repeat
      pfam13431
      Location:139 → 170
      TPR_17; Tetratricopeptide repeat
      pfam13432
      Location:156 → 218
      TPR_16; Tetratricopeptide repeat
      pfam16546
      Location:9 → 48
      SGTA_dimer; Homodimerization domain of SGTA
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJD4 Q9VJD4

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